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BioResearch

Image: Embryonic bowel explants were cultured for three days in basal media alone or this media supplemented with R-Spondin 1. Note that, in the latter condition, there was exuberant growth of tissue from the ends of explants. Bars are 250 microns long (Photo courtesy of the University of Manchester).

Gut Segments Reunite in Model Culture System

An organ culture model system was created to evaluate physical manipulations aimed at enhancing the healing of gut segments in order to generate a single functional organ.  More...
07 Sep 2015
Image: Toxic Alzheimer\'s amyloid beta molecules landing on a fake cell membrane, wrapped around a silver nanoparticle. A laser, with help from the silver particle, lights up the molecule to reveal its structure (Photo courtesy of Dr. Debanjan Bhowmik, Tata Institute of Fundamental Research).

Nanoparticle-Augmented Spectroscopy Reveals Structure of Alzheimer's Disease Peptide

The use of lipid bilayer-encapsulated silver nanoparticles to increase the sensitivity of a Raman spectroscopy technique allowed researchers to determine the structure of Alzheimer's disease-related membrane-attached oligomers of amyloid-beta40 peptide.  More...
06 Sep 2015
Image: Neurons (red) created from ALS patients bearing the C9orf72 mutation show clumps of the RanGAP protein (yellow) in their nuclei (white). The nuclei of other cells are in shown in blue (Photo Jeffrey Rothstein laboratory, Johns Hopkins University).

Long Strands of Repetitive RNA Found to Cause Severe Neurodegenerative Disorders

Neurologists seeking the molecular basis for degenerative disorders such as amyotrophic lateral sclerosis and frontotemporal dementia have linked a mutation in the C9orf72 gene to the malfunction of a protein that normally transports molecules through the nuclear membrane and into the cell's cytoplasm.  More...
06 Sep 2015

European Funding to Advance Development of Prostate Cancer Drug

The development of a drug for treatment of prostate cancer has been given a boost by the recent award of a EUR 2.5 million grant to its Dutch biopharmaceutical company developer.  More...
06 Sep 2015
Image: Comparison of auditory hair cell pathology of murine cochlear tissue explants upon incubation with aminoglycosides paromomycin (PAR) or compound-3, examining by microscopy the cochlear basal-turn region, the area most sensitive to aminoglycoside damage. Staining for actin with rhodamine phalloidin shows the stereocilia and outline of three rows of outer hair cells (OHC) and one row of inner hair cells (IHC). Control (saline only) and treatment at both concentrations of compound-3 (22 μM and 33 μM) left OHC morphology intact, whereas 22 μM PAR caused significant loss of OHCs and 33 μM PAR caused their destruction (Photo courtesy of Shalev M, et al., 2011, and the journal Nucleic Acids Research).

Selective Ribosome-Targeting Drug with Low Ototoxicity Could Provide Safer Treatment Option for Leishmaniasis

In a multidisciplinary biological study, researchers have shed new light on the mechanism of action of a potent drug for leishmaniasis, the natural aminoglycoside paromomycin, and have found that a new synthetic derivative of PAR may provide a far lower risk of irreversible hearing loss side-effects, probably via its more selective targeting of cytosolic (vs. mitochondrial) ribosomes.  More...
02 Sep 2015
Image: The ChilliBlock modular system for precise, controlled cooling and heatingof biological samples (Photo courtesy of Asynt).

Modular Cooling/Heating System Safeguards Temperature-Sensitive Biological Samples

A new modular system designed for precise, controlled cooling and heating of biological samples in microplates, vials and Eppendorf tubes is now available for biotech, clinical, and life science laboratories.  More...
02 Sep 2015
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New Instrument Combines Ultrafast High-Pressure Freezing with Integrated Light Stimulation

A new generation high-pressure freezer with fully integrated millisecond light stimulation option is now available to biotech and other life sciences researchers.  More...
02 Sep 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.