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BioResearch

Image: Ball-and-stick model of the docetaxel molecule (Photo courtesy of Wikimedia Commons).

Nanoparticle-Delivered Drug Cocktail Blocks Spread of Malignant Melanoma Through the Lymph System

A nanoparticle-based delivery system was used to transport a cocktail of three anticancer drugs to the lymph nodes, which prevented the spread of malignant melanoma in two mouse models.  More...
21 Dec 2015
Image: Three-dimensional structure of L-fucose (Photo courtesy of the [US] National Institutes of Health).

Fucose Metabolism Linked to Tendency of Melanomas to Metastasize

A recent paper linked disruptions in the metabolism of the sugar L-fucose to the tendency of melanoma cells to break away from the primary skin tumor and metastasize to other organs in the body.  More...
20 Dec 2015
Image: A- Labeled stem cells target spinal bone fracture; B- Two spinal bone fractures; C- Complete healing of spinal bone fractures eight weeks post treatment with stem cells and PTH (Photo courtesy of Cedars-Sinai Board of Governors Regenerative Medicine Institute).

Combined Stem Cell and Hormonal Therapy Stimulates Bone Growth and Repair

A novel regimen to promote healing of damaged or broken bones is based on combined stem cell and hormonal treatment.  More...
20 Dec 2015
Image: Representation of the molecular structure of pertussis toxin. It is composed of five kinds of subunits. S1: green S2: cyan S3: purple S4: yellow (double) S5: red (Photo courtesy of Wikimedia Commons).

Monoclonal Antibody Treatment Decreases Severity of Whooping Cough in Animal Models

A pair of antibodies directed against pertussis toxin was shown in animal models to increase bacterial clearance and prevent the rise in white blood cell counts associated with poor prognosis in infants.    More...
16 Dec 2015
Image: The BioXp 3200 System (Photo courtesy of Synthetic Genomics Inc. (SGI-DNA Inc.)).

First Add-On Module Automates Cloning of DNA Sequences

The producer of the world's first commercial "DNA printer" is introducing a cloning module that will endow the system with the ability to synthesize and clone custom-designed DNA with an overnight instrument run.  More...
16 Dec 2015
Image: Colorized scanning electron micrograph (SEM) shows a grouping of methicillin resistant Staphylococcus aureus (MRSA) bacteria magnified 20,000 times (Photo courtesy of the CDC – US Centers for Disease Control and Prevention).

SecA Inhibitors Block Growth of Methicillin-Resistant Staphylococcus aureus

A novel class of low molecular weight compounds has been shown to effectively inhibit the growth of methicillin-resistant Staphylococcus aureus, one of the most serious drug-resistant bacterial pathogens.  More...
15 Dec 2015
Image: Standard histology H&E (hematoxylin and eosin) staining of tissue from an eight-year-old Alexander disease patient. Rosenthal fibers—the hallmark of the disease—are shown in pink; nuclei are shown in blue (Photo courtesy of Liqun Wang, Feany Laboratory, Brigham and Women\'s Hospital).

Development of Neurodegenerative Diseases Linked to Astrocyte Nitric Oxide Signaling

Nitric oxide signaling, initiated by brain astrocytes, has been linked to the destruction of neurons that characterizes many neurodegenerative diseases.  More...
15 Dec 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.