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BioResearch

Image: Researchers have shown how controlling cholesterol metabolism in pancreatic cancer cells reduces metastasis to other organs, pointing to a potential new treatment. Findings showed a higher number of metastatic lesions in organs of untreated and treated mice, shown at top and bottom, respectively (Photo courtesy of Dr. Junjie Li, Purdue University).

Inhibition of Cholesterol Esterification Suppresses Growth of Pancreatic Cancer Cells

A team of cancer researchers has suggested that controlling cholesterol metabolism within tumor cells represents a novel approach towards treating the disease. More...
18 May 2016
Image: A structural model of the cathepsin S (CTSS) protein (Photo courtesy of Wikimedia Commons).

Protein Imbalance Linked to Presence of Biomarker in Tears of Sjögren’s Syndrome Patients

Increased expression of cathepsin S (CTSS) activity has emerged as a unique biomarker in the tears of Sjögren’s syndrome (SS) patients. More...
17 May 2016
Image: Molecular structure of factor H bound to C3b. In order to avoid self-attack, regulatory proteins such as factor H bind with C3b, a central component of the enzyme C3 convertase, to help the immune system recognize the body’s own tissue and keep complement in check (Photo courtesy of the University of Pennsylvania School of Medicine).

Antibodies against Complement Factor H Selectively Destroy Tumor Cells

Cancer researchers have identified and produced a monoclonal antibody that destroys tumor cells by blocking the activity of the protective protein complement factor H (CFH). More...
17 May 2016
Image: After treatment with riluzole, the brains of old rats showed more of a transporter molecule that removes excess glutamate, (green fluorescence, right) as compared to untreated rats (left) (Photo courtesy of The Rockefeller University).

Glutamate Modulator Reverses Genetic Expressions of Aging and Alzheimer's Diease in Rodent Model

Neurological disease researchers have found that the glutamate modulator riluzole reversed gene expression profiles caused by age and Alzheimer’s disease (AD) in a rat AD model. More...
16 May 2016
Image: Aggregated SOD1 protein can be seen as green dots in the cell fluid of a motor neuron in the spinal cord of an ALS patient. The red area is the nerve cell nucleus (Photo courtesy of Peter Andersen, Umeå University).

Mutant Protein Aggregates Drive Progression of ALS in Mouse Model

Researchers working with a mouse model of amyotrophic lateral sclerosis (ALS) have demonstrated that aggregates of mutated superoxide dismutase 1 (SOD1) can propagate the disease by progressing through nerve cells along the animal's spinal cord. More...
16 May 2016
Image: A human heart cell that was chemically reprogrammed from a human skin cell (Photo courtesy of Dr. Nan Cao, Gladstone Institutes).

Stem Cells Induced by Low Molecular Weight Compounds Transform into Working Heart and Brain Cells

A team of cell biologists has demonstrated the feasibility of using cocktails of low molecular weight compounds to induce skin cells to revert to a stem cell-like state that allowed them to be reprogrammed into cardiac or neural cells. More...
12 May 2016
Image: A diagram showing how different domains of the NMDA receptor move when the receptor is in active, non-active, and inhibited states. Understanding how NMDA receptors activate is critical in designing novel therapeutic compounds for potential use in schizophrenia, depression, and other disorders (Photo courtesy of Furukawa Lab, Cold Spring Harbor Laboratory).

Study Reveals Active and Non-Active Structures of the NMDA Receptor

Advanced imaging techniques were used to obtain the three-dimensional structure of the NMDA (N-methyl, D-aspartate) receptor in active and non-active states. More...
12 May 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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