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BioResearch

Image: In the mouse spleen, lymphoid tissue (purple) is responsible for launching an immune response to blood-born antigens, while red pulp (pink) filters the blood. Mutations in the C9ORF72 gene, the most common mutation found in ALS patients, can inflame lymphoid tissue and contribute to immune system dysfunction (Photo courtesy of Dr. Dan Mordes, Eggan Laboratory, Harvard Stem Cell Institute).

Loss-of-Function Mutation Causes ALS in Mouse Model

Neurological disease researchers working with a mouse model of amyotrophic lateral sclerosis (ALS) have shown that the condition is critically linked to a loss-of-function mutation in the C9ORF72 (chromosome 9 open reading frame 72) gene. More...
25 Jul 2016
Image: A strong biglycan signal (red) was detected in the tumor blood vessel area of a metastatic case (right) but was barely detected in the tumor tissues of a non-metastatic case (left) (Photo courtesy of Maishi N. et al., Scientific Reports).

Biglycan in the Tumor Microenvironment May Act As Metastasis Trigger

A small proteoglycan secreted from endothelial cells within the tumor microenvironment has been linked to the likelihood of the primary tumor metastasizing and freeing cells to travel to other parts of the body. More...
25 Jul 2016

Collaborative Agreement to Aid in Setting Guidelines for Evaluating Potential Ebola Therapy

Cooperation between an Israeli biopharmaceutical company and medical branches of the US government is designed to set ground rules for continued evaluation of an experimental therapy for Ebola virus disease. More...
25 Jul 2016

Sartorius Acquires US Start-up ViroCyt

Sartorius AG (Göttingen, Germany), a pharmaceutical and laboratory equipment provider, has acquired ViroCyt Incorporated (Broomfield, CO, USA), a start-up in the field of rapid virus quantification, in a deal valued at approximately USD 16 million. More...
22 Jul 2016
Image: The green-labeled cells show a basal cell carcinoma in mouse tail epidermis derived from a single mutant stem cell and expanding out of the normal epidermis stained in red (Photo courtesy of Adriana Sánchez-Danés, Université Libre de Bruxelles).

Stem Cells Not Progenitors Can Trigger Skin Cancer Growth

Cancer researchers have discovered that stem cells can initiate development of malignant skin tumors, while progenitor cells are limited to triggering only benign growths. More...
21 Jul 2016
Image: A normal muscle (left) is compared to a muscle lacking beta1-integrin (right) (Photo courtesy of Chen-Ming Fan, Michelle Rozo / Carnegie Institution for Science).

Age-Related Lack of Attachment Proteins Diminishes Regenerative Ability of Muscle Tissue

The cellular attachment proteins fibronectin and beta1-integrin have been linked to age-related changes that limit the ability of muscle tissue to regenerate and in the reduced maintenance of muscle stem cells. More...
20 Jul 2016
Image: A crystal structure model of the surface of the AAV-2 serotype of adeno-associated virus (Photo courtesy of Wikimedia Commons).

Alpha-1-Antitrypsin Gene Replacement Therapy Cures Emphysema in Mouse Model

A virus-like vector loaded with the gene for production of the enzyme alpha-1-antitrypsin (AAT) successfully established production of the protein in the lungs of mice serving as a model for human emphysema. More...
19 Jul 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.