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BioResearch

Image: The structure gives scientists a new view of Lymphocytic choriomeningitis mammarenavirus (LCMV), a close relative of the Lassa fever virus (Photo courtesy of the Ollmann Saphire Laboratory, The Scripps Research Institute).

X-Ray Crystallography Reveals Structure of the Arenavirus Binding Complex

A team of molecular virologists has established the three-dimensional structure of the intensely studied research tool, Lymphocytic choriomeningitis mammarenavirus (LCMV). More...
11 May 2016
Image: A photomicrograph shows a well-differentiated structure derived from normal embryonic stem cells, with all nuclei stained blue. Only endoderm cells (green) contain high levels of lysosomes (red) (Photo courtesy of Dr. Anwesh Kamireddy, Salk Institute for Biological Sciences).

Stem Cell Differentiation Depends on the Central Metabolic Regulator AMPK

The ability of stem cells to differentiate into mature tissue depends on the activity of the central metabolic regulator AMP-activated protein kinase (AMPK). More...
11 May 2016
Image: A scanning electron microscope (SEM) image showing zinc oxide tetrapod nanoparticles (ZOTEN) (Photo courtesy of Dr. Deepak Shukla, University of Illinois).

Nanoparticle Treatment Prevents Herpes Infection in Mouse Model

A novel type of nanoparticle was shown to effectively prevent infection by herpes simplex virus-2 (HSV-2), the virus that causes chronic genital herpes. More...
10 May 2016
Image: A photomicrograph of myeloblasts in bone marrow of patient with acute myeloid leukemia (AML) (Photo courtesy of Wikimedia Commons).

MicroRNA Downregulation Boosts Growth of Acute Myeloid Leukemia Cells

Acute myeloid leukemia (AML) cells have developed a mechanism to suppress the activity of the microRNA miR-22, which would otherwise act to block their growth. More...
10 May 2016
Image: A photomicrograph of human brain tumor stem cells expressing the OSMR gene (green) (Photo courtesy of Dr. Arezu Jahani-Asl, McGill University).

Gene Pair Acts in Tandem to Drive Aggressive Brain Cancer Growth

A pair of genes has been identified that work in tandem to drive the growth and development of the glioblastoma multiforme (GBM) type of aggressive brain tumor. More...
09 May 2016
Image: An expression of NOTCH 1 (green color) in ACC stem cells (Photo courtesy of Yale University).

Adenoid Cystic Carcinoma Stem Cells Depend on NOTCH1 and SOX10 Signaling

Cancer researchers have isolated a stem cell population from the cells making up an adenoid cystic carcinoma (ACC) tumor and showed that the signaling factors NOTCH1 and SOX10 were essential for the cancer stem cells to proliferate and resist radiation treatment. More...
05 May 2016
Image: An artistic rendering of the Zika virus structure (Photo courtesy of Dr. Guntur Fibriansah, Duke-NUS Medical School).

High Resolution Structure of Zika virus Expected to Aid Vaccine Development

A team of molecular virologists used advanced cryo-electron microscopy techniques to establish a high-resolution structure for the Zika virus, a formerly neglected pathogen that has recently been associated with microcephaly in fetuses and with Guillian–Barré syndrome in adults. More...
04 May 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.