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BioResearch

Image: The enzyme HtrA1 shown in the image degrades ApoE4, the strongest genetic risk factor for Alzheimer’s disease, providing new information that might eventually lead to new treatments for the neurodegenerative disorder (Photo courtesy of Salk Institute for Biological Studies).

Release of ApoE4 Fragments and Increased Tau Protein Contribute to Risk of Alzheimer's Disease

Results of a recent study suggested that the interaction between apolipoprotein E4 (ApoE4) and the enzyme high-temperature requirement serine peptidase A1 (HtrA1) was linked in some fashion to the development of late onset Alzheimer's disease (AD). More...
31 Aug 2016
Image: A colored transmission electron micrograph (TEM) of norovirus (Photo courtesy of  Charles D. Humphrey, CDC).

Researchers Identify Cell Surface Protein Required for Norovirus Infection

Molecular virologists working with a mouse norovirus strain identified and characterized a cell surface protein that was required by the virus to gain entry into the host cell. More...
31 Aug 2016
Image: The first 3D map of the cancer-associated protein DCLK1 (doublecortin-like kinase 1), revealed how it functions (Photo courtesy of Walter and Eliza Hall Institute).

Kinase Domain Mutation Causes Protein Malfunction and Tumor Development

A team of chemical biologists has generated the first molecular map of the protein doublecortin kinase like domain 1 (DCLK1), a factor linked to more than 10% of gastric cancers that has also been found in kidney, rectal, and pancreatic cancers. More...
29 Aug 2016
Image: The crystal structure of Cas9 bound to DNA (Photo courtesy of Wikimedia Commons).

Unrelated Single-Stranded DNA Increases Efficiency of CRISPR-Cas 9 Gene Editing

The addition of a short section of single-stranded DNA to the reaction mixture significantly enhances the efficiency of the CRISPR/Cas9 gene editing technique. More...
29 Aug 2016
Image: Healthy blood cells along with sickle-cell diseased cells (Photo courtesy of Science Picture Co./Corbis).

Gene Editing Corrects Hemoglobin Defects in Beta-Thalassemia and Sickle Cell Disease

A team of hematology researchers used the CRISPR/Cas9 gene editing technique to correct the mutations that cause defective blood cell morphology in beta-thalassemia and sickle cell disease. More...
25 Aug 2016
Image: An illustration of long non-coding RNAs (Photo courtesy of Julia Yellow).

Long Non-Coding RNAs Linked to Development and Progression of Prostate Cancer

Cancer researchers have found a link between a number of long non-coding RNAs and the development and progression of prostate cancer. More...
25 Aug 2016
Image: The lungs of mice co-infected with both influenza and MRSA appear much healthier after combined treatment with antibiotics and an NADPH oxidase inhibitor (right) than they do after antibiotic treatment alone (left) (Photo courtesy of Dr. Keer Sun).

NADPH Oxidase Inhibitor Treatment Protects Mice from Being Killed by Pneumonia

Influenza sufferers who develop methicillin-resistant Staphylococcus aureus (MRSA) pneumonia often die from damage caused to their lungs by reactive oxygen species released from necrotic inflammatory cells. More...
25 Aug 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.