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BioResearch

Image: A brain section from mouse carrying the dementia-causing P301S mutation in human tau shows accumulation of tau neurofibrillary tangles (in dark brown, left). When Nuak1 levels are decreased by 50% (P301S/Nuak1+/-; right), fewer tau tangles accumulate (Photo courtesy of the Zoghbi Laboratory, Baylor College of Medicine).

Enzyme Identified Stabilizes Tau and Prevents Neurodegenerative Disease

Neurodegenerative disease researchers used three different model systems to screen for and identify a gene able to stabilize levels of tau protein in neurons and prevent it from accumulating in amounts capable of injuring or killing the cells. More...
04 Nov 2016
Image: The protein produced by the adenomatous polyposis coli (APC) tumor suppressor gene (Photo courtesy of Wikimedia Commons).

Candidate Drug Kills CRCs with Mutated Tumor Suppressor Gene

A candidate small molecule drug for treatment of colorectal cancer acts by blocking cholesterol biosynthesis in a subset of tumor cells that carry a mutated version of a gene that normally suppresses tumor formation. More...
04 Nov 2016
Image: In this image, the top row shows few T-cells in untreated mice, while the bottom rows show many T-cells produced after immunotherapy treatment (Photo courtesy of Massachusetts Institute of Technology).

Novel Immunotherapy Approach Shrinks or Eliminates Advanced Tumors

A novel four-component approach to anti-cancer immunotherapy overcame the complex network of immunosuppressive pathways present in advanced tumors and caused shrinkage of several types of tumors in different mouse models. More...
03 Nov 2016
Image: Human CPEB1 protein is shown here in green, while cytomegalovirus (HCMV) is orange (Photo courtesy of the University of California, San Diego).

RNA Binding Protein Required for Successful Infection by HCMV

A team of molecular virologists has catalogued the interactions that occur at the genetic level when cytomegalovirus (HCMV) infects human cells. More...
03 Nov 2016
Image: The experimental drug NGI-1 slows cancer growth by blocking glycosylation of the epidermal growth factor receptor (EGFR), which is shown in the above diagram (Photo courtesy of Wikimedia Commons).

Experimental Drug Slows Lung Cancer Growth by Blocking Protein Glycosylation

An interesting new experimental anti-cancer drug slows growth of certain lung tumor cells by preventing the glycosylation of critical cell surface receptor proteins. More...
03 Nov 2016
Image: Molecular model of the enzyme encoded by the KAT2A gene (Photo courtesy of Wikimedia Commons).

CRISPR/Cas9 Identifies Potential Drug Target in Acute Myeloid Leukemia

The CRISPR/Cas9 genome editing technique was modified to identify genes critical for the survival and growth of acute myeloid leukemia (AML) cancer cells. More...
27 Oct 2016
Image: Photomicrographs show that placebo-treated cells (left) have far more lipid (red) production compared to ND-646 treated cells (right) (Photo courtesy of the Salk Institute).

Experimental Drug Shrinks Lung Tumors by Blocking Fatty Acid Synthesis

An experimental drug that blocks the activity of the enzyme that regulates de novo fatty acid synthesis caused a dramatic reduction in the size of tumors in animal models of non-small-cell lung cancer (NSCLC). More...
27 Oct 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.