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BioResearch

Image: Investigators have developed nanoparticles that can transport the CRISPR genome-editing system in vivo and specifically modify genes, eliminating the need to use viruses for delivery (Photo courtesy of Massachusetts Institute of Technology).

Nanoparticle-Based System Developed for Delivery of CRISPR/Cas9

A novel nanoparticle transport system was used to deliver the CRISPR/Cas9 genome editing tool into liver cells of living mice, which caused silencing of a specific enzyme and significant lowering of cholesterol levels. More...
30 Nov 2017
Image: CRISPR/Cas9-mediated disruption of genes associated with cuticle pigment caused mosquitoes to turn from black to yellow, and disruption of genes associated with eye pigment caused eye color to change from black to white (Photo courtesy of the University of California, Riverside).

Transgenic Cas9 Mosquitoes Used to Target Disease Carriers

Insertion of the gene encoding the Cas9 enzyme into the germline of Aedes aegypti mosquitos represents a step toward the development of novel population control technologies targeting this carrier of serious viral pathogens including dengue, chikungunya, yellow fever, and Zika. More...
29 Nov 2017
Image: A lysosome ultrastructure (Photo courtesy of Hourlybook Open Source Education Blog).

Researchers Link PD Risk to Lysosomal Gene Mutations

A team of neurodegenerative disease researchers has suggested that multiple genetic defects may act in combination to degrade lysosomal function, which enhances Parkinson’s disease (PD) susceptibility. More...
28 Nov 2017
Image: Cells treated with a chemical carcinogen show severe liver cancer development. In cells treated with the same dosage of a chemical carcinogen and given synthetic dsRNA treatment at the pre-cancer stage, tumor suppression occurred (Photo courtesy of the University of California, San Diego).

Synthetic RNA Blocks Tumor Formation in Cancer Model

A team of cancer researchers demonstrated that the synthetic double-stranded RNA (dsRNA), polyinosinic-polycytidylic acid (pIC), could block the formation of liver tumors in a mouse model. More...
27 Nov 2017
Image: A photomicrograph showing DAG (green-labeled peptide) targeting to the brain blood vessel (labeled red) in the hippocampus of the Alzheimer brain (Photo courtesy of the Ruoslahti Laboratory, Sanford-Burnham Prebys Medical Discovery Institute).

Novel Peptide Targets Injured Brain Tissues

A novel peptide with potential therapeutic use for the treatment of neurological disorders such as Alzheimer's disease (AD) and Parkinson's disease was identified by in vivo phage display screening. More...
24 Nov 2017
Image: Glycyrrhiza uralensis (Chinese licorice) is the source of the neuroprotective compound liquiritigenin (Photo courtesy of Wikimedia Commons).

Traditional Chinese Medicinal Plant Extract Protects against PD

A team of Korean neurodegenerative disease researchers has identified a naturally occurring drug that prevents the death of dopamine-producing neurons that characterizes Parkinson's disease. More...
22 Nov 2017
Image: Investigators loaded light-activated nanoshells (gold and light blue) with the anticancer drug lapatinib (yellow) by encasing the drug in an envelope of albumin (blue). Light from a near-infrared laser (center) was used to remotely trigger the release of the drug (right) after the nanoshells were taken up by cancer cells (Photo courtesy of A. Goodman, Rice University).

Gold Nanoshells Safely Deliver Toxic Chemotherapeutic Drugs

A novel method for delivering toxic drugs to tumor cells relies on the use of light-activated gold nanoparticles, which are triggered remotely by laser light to release the drugs inside the cancer cells. More...
21 Nov 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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