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BioResearch

Image: A model of the KRAS protein with important domains highlighted (Photo courtesy of ResearchGate).

Exosomes Prove Superior for Transporting Anticancer MicroRNAs

Cancer researchers used modified exosomes to transport inhibitory siRNA molecules to block the activity of the KRAS oncogene and thereby suppress cancer development in multiple mouse models of pancreatic cancer and significantly increase overall survival. More...
20 Jun 2017
Image: A photomicrograph showing T-cells (red) and tumor cells (green) incubated with control particles (left) or immunoswitch particles (right). The T-cells that have attached to tumor cells are indicated by green arrows (Photo courtesy of Alyssa Kosmides, Johns Hopkins University).

Bifunctional Nanoparticles Show Potential in Cancer Models

To be successful, an immunotherapeutic approach for treating cancer must overcome the immunosuppressive effects of the tumor microenvironment; a novel bifunctional nanoparticle does just that. More...
19 Jun 2017
Image: Dr. Kim and his team are using breakthrough gene-editing technology to develop a new screening tool for Parkinson’s disease. The technology allows scientists in the lab to “light up” and then monitor a brain protein called alpha-synuclein that has been associated with Parkinson’s (Photo courtesy of the University of Central Florida).

CRISPR/Cas9 Technology Used to Help Screen for PD

A team of neurodegenerative disease researchers used CRISPR/Cas9 gene editing technology to introduce a luminescent reporter into the gene that encodes the pathogenic protein alpha-synuclein, an approach that they plan to develop into a screening tool for drugs to treat Parkinson's disease (PD). More...
16 Jun 2017

MicroRNA Protects Normal Brain from Trauma and Stress

A microRNA has been identified that helps prevent the normal brain from becoming susceptible to the type of seizures induced by trauma or stress in individuals with epilepsy. More...
14 Jun 2017
Image: A glucose-controlling drug (blue) is shown completely dissolving after 24 hours in the body of a mouse in the top two photos. In the bottom two images, a newly optimized version of a diabetes treatment forms a \"depot\" for controlled release that persists more than 24 hours (Photo courtesy of Dr. Ashutosh Chilkoti, Duke University).

Time-Release Approach for Treating Type II Diabetes

A novel approach to treating type II diabetes is based on a timed-release suspension of glucagon-like peptide-1 (GLP1) embedded in a thermosensitive elastin-like polypeptide complex. More...
13 Jun 2017
Image: A micrograph showing cirrhosis, a form of liver fibrosis (Photo courtesy of Wikimedia Commons).

Cytokine Drives Scar Formation in the Liver

Researchers have identified a cytokine that contributes strongly to the processes involved in the formation of scars in the liver, such as those that form as a consequence of hepatitis C infection. More...
12 Jun 2017
Image: The Cytation 1 cell imaging multimode reader (Photo courtesy of BioTek Instruments).

New Digital Microscope Boasts Augmented Software

A new automated digital quantitative multi-mode microscope has been released for use by biotech and other life science researchers. More...
08 Jun 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.