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BioResearch

Image: Under a very-high magnification, this digitally colorized scanning electron micrograph (SEM) depicts a number of filamentous Ebola virus particles (red) that had budded from the surface of a VERO cell (brown) of the African green monkey kidney epithelial cell line (Photo courtesy of the [U.S.] National Institute of Allergy and Infectious Diseases).

Compound Demonstrates Potential as Broad-Spectrum Antiviral Drug

A team of molecular biologists identified a potent drug candidate with specificity towards especially deadly viruses such as Ebola virus and Marburg virus. More...
12 Apr 2018
Image: Malik et al conducted a multi-ancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32 (Photo courtesy of Gerd Altmann).

Stroke Genetics Study Triples Number of Known Risk Loci

Results of one of the largest genome-wide-association studies (GWAS) to be carried out on stroke revealed 22 new stroke risk loci, bringing the total to 32, which more than triples the number of gene regions known to affect stroke risk. More...
11 Apr 2018
Image: Genetically modified astrocytes (red) line the lesion border in the injured spinal cord. A new mouse study showed that triggering a gene inside astrocytes activated the star-shaped cells and may improve the brain’s ability to heal from a range of debilitating conditions, from stroke to concussions and spine injuries (Photo courtesy of Dr. Meifan Amy Chen, University of Texas Southwestern Medical Center).

Critical Brain Cell Repair Gene Identified in Study

Repair of damaged brain cells depends on the process of astrogliosis, which has been shown to be regulated by the MAP3K13 (also known as leucine zipper-bearing kinase [LZK]) gene. More...
10 Apr 2018
Image: Antibodies against APOE (red) bind to amyloid plaques (blue) in brain tissue from people with Alzheimer\'s disease. Investigators have found that the antibody can sweep away the damaging plaques, at least in mice, which could lead to a therapy for the devastating disease (Photo courtesy of Monica Xiong, Washington University School of Medicine).

Antibody Clears Amyloid Plaques in Mouse Model

A team of Alzheimer's disease researchers working with a mouse model identified a specific antibody capable of binding to and mediating the removal of the amyloid plaques that characterize this catastrophic neurodegenerative disorder. More...
10 Apr 2018
Image: A diagram of a 5-AZA resistant chromatin structure (Photo courtesy of Dr. Jason Cheng).

Role of RNA Methylation Defined in Drug Resistance by Leukemia Cells

Results of a recent study defined the roles of RNA 5-methylcytosine (RNA:m5C) and RNA:m5C methyltransferases (RCMTs) in the formation of discrete chromatin structures that modulate 5-Azacitidine (5-AZA) response or resistance in leukemia cells. More...
05 Apr 2018
Image: A family of economical silver-based complexes shows very promising results against a number of human cancers in laboratory tests, with very low toxicity in rat studies and minimal effects on healthy cells. One of these complexes, UJ3, is as effective as the industry-standard drug Cisplatin in killing cancer cells in laboratory tests done on human esophageal cancer, breast cancer, and melanoma. This matrix of light microscope images shows a comparison of human esophageal cancer cells treated with UJ3 and Cisplatin (Photo courtesy of Dr. Zelinda Engelbrecht, University of Johannesburg).

Less Toxic Drugs May Replace Current Chemotherapeutic Agents

A team of South African cancer researchers has suggested replacing the current frontline platinum-based chemotherapeutic drugs with first generation silver(I) phosphines, which have vast structural diversity and promising anticancer activity. More...
04 Apr 2018
Image: Ripe pecan-nuts photographed on a tree in Hadera, Israel (Photo courtesy of Wikimedia Commons).

Pecan-Enriched Diet Protects against CV Disease and Diabetes

Results of a randomized, controlled feeding trial suggested that eating just 1.5 ounces (44.36 milliliters) of pecans every day could protect adults at risk for developing cardiovascular disease (CVD) and type II diabetes. More...
03 Apr 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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