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BioResearch

Image: An adenovirus without and with a novel protein shield. The adenovirus (left) was camouflaged from the immune system by the protective coat (right) (Photo courtesy of the University of Zurich).

Modified Adenovirus Vector Used for Cancer Gene Therapy

A team of medical virologists has modified the commonly used adenovirus vector to both avoid clearance by the immune system and liver and to specifically target and invade tumor cells. More...
15 Feb 2018
Image: Vials containing samples of \"hairy\" nanoparticles: the right and left vials contain photo-responsive polymer-capped gold nanoparticles prior to and after self-assembly, respectively. The center vial shows dye released from self-assembled gold nanoparticles. The nanoparticles were made with light-sensitive materials that assembled and disassembled themselves when exposed to light of different wavelengths (Photo courtesy of Rob Felt, Georgia Institute of Technology).

Light-Sensitive Nanoparticles Designed for Smart Drug Release

A novel type of "smart" nanoparticles responds to light of specific wavelengths that causes the particles to assemble or disassemble, which enables the dynamic organization of the nanoparticles for in vitro drug release. More...
14 Feb 2018
Image: A three-dimensional-printed chess king shrinking and growing as water temperatures change (Photo courtesy of Daehoon Han, Rutgers University).

3D Hydrogel Structures Developed for Biomedical Use

A team of biomedical engineers developed a three-dimensional printing method for stimuli-responsive hydrogels that may enable many new applications in diverse areas, including flexible sensors and actuators, bio-medical devices, and tissue engineering. More...
13 Feb 2018
Image: The structure of the OX40 protein (Photo courtesy of Wikimedia Commons).

Immunostimulatory Vaccine Cures Metastatic Cancer in Model

A novel method for treating various types of metastatic cancer based on injection of a pair of immune-stimulating agents directly into solid tumors was demonstrated in a mouse model. More...
12 Feb 2018
Image: The structure of the cancer stem cell-promoting SOX2 protein (Photo courtesy of Wikimedia Commons).

Potential Therapy Blocks Cancer Stem Cell Survival

A suggested new drug regimen for treating bladder cancer targets two enzymes that act to increase the expression of a third enzyme that promotes the survival and growth of a drug resistant population of cancer stem cells. More...
08 Feb 2018
Image: Transmission electron micrograph (TEM) of two oncolytic adenovirus particles of the type modified to target pancreatic cancer cells (Photo courtesy of Wikimedia Commons).

Targeted Oncolytic Virus Selectively Attacks Cancer Cells

A team of British molecular virologists modified a previously reported oncolytic adenovirus to selectively target the alphavbeta6 integrins expressed by pancreatic cancer cells to facilitate systemic delivery and destruction of pancreatic ductal adenocarcinomas (PDAC). More...
07 Feb 2018
Image: A micrograph of pancreatic ductal adenocarcinoma (the most common type of pancreatic cancer) (Photo courtesy of Wikimedia Commons).

Nanoparticles Deliver Small RNAs to Treat Pancreatic Cancer

A team of Israeli cancer researchers used novel supramolecular nanocarriers to deliver a potent combination of microRNA and siRNA to attach and destroy pancreatic ductal adenocarcinoma tumors in a mouse model.
 
 
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06 Feb 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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