More-Sensitive Rat Microarray for Genome Screening

A 60-mer oligonucleotide rat microarray kit for genome screening and toxicogenomic research is designed for use in drug discovery and development.

The microarray kit will be used to identify toxic substances and understand how human genes respond and interact in human disease caused by environmental pollutants or toxicants. The kit was developed by Agilent Technologies, Inc. (Palo Alto, CA, USA; www.agilent.com), in collaboration with the US National Institute of Environmental Health Sciences (NIEHS) and Paradigm Genetics (Research Triangle Park, NC, USA).
Agilent said this microarray is 5-10 times more sensitive than regular 25-mer arrays.

Rat genes were selected on the latest content of the public RefSeq database, human and mouse homologues, and proven toxic response genes identified by NIEHS. The kit includes five microarrays, printed on standard glass slides, with more than 20,000 unique rat gene probes per microarray, providing broad genome coverage and specialized content for toxicogenomics researchers.

"We hope these advancements will slash the time and expense of testing chemicals for potential harmful effects, enabling faster and more scientifically based regulatory decision-making,” said Heinrich Gugger, Ph.D., president and CEO of Paradigm Genetics.




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