Experimental Physicists Find Clues into How Radiotherapy Kills Cancer Cells

A new discovery in experimental physics has implications for a better determination of the process in which radiotherapy destroys cancer cells.

Dr. Jason Greenwood from Queen’s University Belfast (Ireland) Center for Plasma Physics collaborated with scientists from Italy and Spain on the work on electrons, and published this groundbreaking finding October 17, 2014, in the international journal Science. By means of some of the shortest laser pulses, the researchers employed strobe lighting to monitor the ultra-fast movement of the electrons within a nanometer-sized molecule of amino acid. The resulting oscillations—lasting for 4,300 attoseconds—amount to the fastest process ever observed in a biologic structure.

Dr. Greenwood said, “Explaining how electrons move on the nanoscale is crucial for the understanding of a range of processes in matter as it is this charge which initiates many biological, chemical, and electrical processes. For instance, the charge produced from the interaction of ionizing radiation with DNA and its subsequent ultra-fast movement can lead to damage of the DNA and cell death which is exploited in radiotherapy to treat cancer. This knowledge is therefore important for understanding the action of radiotherapy beams in cancer treatment. Being able to describe how light interacts with electrons on these timescales could also lead to improvements in how light is converted into electricity in solar cells or faster microprocessors, which use light rather than electrical signals for switching transistors.”

The research was performed by Queen’s School of Mathematics and Physics in collaboration with the Politecnico Milano (Italy), the Universidad Autónoma of Madrid (Spain), University of Trieste (Italy), and Institute of Photonics and Nanotechnologies IFN-CNR (Padua, Italy).

Dr. Greenwood concluded, “This research will hopefully open up the emerging field of attosecond science which seeks to understand how ultrafast electrons play a key role in chemistry, biology and nanotechnology. This is very early research but this new field of ultrafast light-induced electronics is likely to have an impact in biology, chemistry and materials in the next five to 10 years. Practical applications down the line may include improvements in cancer radiotherapy, highly efficient solar cells, and much faster computer processors.”

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Queen’s University Belfast
Politecnico Milano 
Universidad Autónoma of Madrid