Drug Development Projects to Benefit from Enhanced Liver Toxicity Data

An advanced cartridge add-on package for cell-cytometry imaging provides dedicated, real-time data on the toxic effects of potential candidate drug compounds on liver cells.

The Thermo Fisher Scientific Inc. (Milford, MA, USA) ToxInsight DILI (drug-induced liver injury) Assay Cartridge is a groundbreaking new tool for assessing the liver toxicity risk of chemical compounds.

The DILI Assay Cartridge was designed to be used with the Thermo Scientific ToxInsight IVT image cytometry platform. The powerful analytical and visualization software that powers this add-on module enables the system to identify drug-induced hepatotoxicity by simultaneous detection of multiplexed toxicity biomarkers in single cells. The package includes all the reagents, assay protocols, analysis, and data reporting capabilities needed to profile compounds for hepatotoxicity with high sensitivity and specificity.

The ToxInsight IVT platform makes multiple measurements on each cell, generating a phenotype rather than a single measurement. This automated, bench-top platform is easy to use and provides physiologically relevant toxicity assays early in the drug discovery process, eliminating reliance on late-stage histopathology or animal studies. Furthermore, the ToxInsight IVT platform not only profiles compounds for their toxicity risk, it also determines the mechanism of action of any toxicity detected, enabling researchers to understand rapidly the therapeutic index of a compound series in minutes.

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