Recombinant Lysozyme Derived From Plants

A recombinant human lysozyme has been produced in an animal-free system. The bacterial-cell lysis agent can be used in diagnostic applications, bioprocessing, and life science research.

The lysozyme has many advantages over other lysing agents. Because it is produced in an animal-free system, it is free of infectious viral or prion contaminants. Prions are the causative agent of bovine spongiform encephalopathy (BSE), or mad cow disease. The lysozyme outperforms chicken lysozyme, a common animal-derived cell lysis agent, and is four times more active per mg for lysing Micrococcus and E coli. Lysobac, the lysozyme produced by Ventria Bioscience (Sacramento, CA, USA), is available in packages of 100 million, 10 billion, and 100 billion.

Lysobac is a recombinant protein that provides consistent cell lysis results so that process changes are minimized. For bioprocessing applications, it saves time by eliminating steps in the production process because it enables in-culture protein extraction. In addition, Lysobac is highly active and therefore it adds minimal volume to the final extract. It is cheaper than chicken lysozyme because of its high activity and efficient production methods. Lysobac is a gentle lysing agent providing minimal risk of denaturing the protein product.



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