New Tools for Genomics Research

A new microarray tool for genomic research is expected to allow high resolution, sensitive, and reproducible detection of chromosomal abnormalities.

Spectral Genomics Inc. (Houston, TX, USA; www.spectralgenomics.com) uses a proprietary method for producing genomic DNA microarrays that are designed to facilitate the genome-wide analysis of samples from which chromosome preparations are difficult or impossible. Spectral Genomics makes arrays from BAC (bacterial artificial chromosomes) clones. A BAC is a cloning vector derived from the Escherichia coli fertility plasmid, the F-factor. BACs can be used in the cloning of large DNA fragments, on average approximately 200 kb long, and are ideal as cloning vectors for the sequencing of whole genomes.

The new "Constitutional Chip” also includes spots representing negative controls, calibration controls for standardization of detection, and clones not likely to be affected by genetic defects that form the base line for detection. The "Constitutional Chip” is complemented by "SpectralWare,” web-based software that displays chromosomal abnormalities and their loci within the genome as interpreted from images produced by microarray scanners.

Dr. Ed Chait, CEO of Spectral Genomics, said, "It is particularly exciting to see the Spectral team introducing this major innovation in cytogenetics for which we have applied for a patent, allowing our customers and collaborators to experience the superior data that can be obtained from BAC clone microarrays.”




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