Cells of Pulmonary Fibrosis Derive from Bone Marrow Stem Cells
By Biotechdaily staff writers
Posted on 02 Feb 2004
Researchers have found that cells that underlie pulmonary fibrosis derive from bone marrow stem cells rather than from parnechymal lung fibroblasts.Posted on 02 Feb 2004
Pulmonary fibrosis is a condition in which excessive scar tissue is deposited in the lungs, making them stiff and small and interfering with their function. Investigators at the University of Michigan (Ann Arbor, USA) induced pulmonary fibrosis in a line of mice that had been genetically engineered to produce bone marrow stem cells that expressed a green fluorescent protein. They reported in the January 15, 2004, issue of the Journal of Clinical Investigation that the majority of the collagen-producing cells involved in active fibrotic lesions expressed the green fluorescent protein, indicating that they had derived from bone marrow stem cells.
These findings confirm that lung fibroblasts in pulmonary fibrosis are derived from bone marrow stem cells.
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