Preoperative Blood Cell Ratios Predict Endometrial Cancer Survival
|
By LabMedica International staff writers Posted on 02 Aug 2015 |
|
Image: The ADVIA 2120 Hematology System (Photo courtesy of Siemens).
The variations in systemic inflammatory response biomarker levels have been associated with adverse clinical outcome in various malignancies and the host response to malignant tumors is characterized by systemic inflammation, resulting in a relative thrombocytosis, neutrophilia and lymphocytopenia.
Biomarkers of systemic inflammation such as elevated neutrophil:lymphocyte ratio (NLR), platelet:lymphocyte ratio (PLR) and absolute monocyte counts have shown potential for guiding the clinical management of cancer patients across a range of malignancies including endometrial cancer.
Scientists at St James’s University Hospital (Leeds, UK) performed a retrospective study examining the records of a sequential series of 733 patients with a new diagnosis of primary endometrial cancer between January 2005 and December 2007. Patients’ full blood count data, including absolute leukocyte, neutrophil, eosinophil, basophil, monocyte, lymphocyte and platelet counts, were collected from a time frame of less than two weeks prior to hysterectomy and used to calculate NLR, PLR and monocyte:lymphocyte (MLR) ratios. The investigators chose to calculate MLR, the reciprocal of the more frequently used lymphocyte:monocyte ratio (LMR), to standardize by dividing myeloid lineage counts by lymphoid lineage cell counts for all relevant variables.
Full blood counts were performed on the Advia 2120 hematology analyzer (Siemens; Erlangen, Germany). The team applied cut-offs of greater than or equal to 2.4 (NLR), greater than or equal to 240 (PLR) and greater than or equal to 0.19 (MLR). NLR and PLR, but not MLR had independent prognostic significance. They combined NLR and PLR scores and stratified patients into low (NLR-low and PLR-low), intermediate (NLR-high or PLR-high) and high risk (NLR-high and PLR-high) groups. Increased NLR and PLR were most strongly associated with advanced stage, whereas increased MLR was strongly associated with older age. Both NLR and PLR were identified as having independent prognostic value when adjusted for age, stage, grade, lymphovascular space invasion and histopathological subtype.
The authors concluded that they have highlighted the potential of NLR and PLR as additional prognostic tools and despite their inter-relationships, both NLR and PLR proved to be better prognostic indicators than MLR in endometrial cancer. These are simple measures which are essentially cost-neutral and which could aid decision-making in the clinical management of endometrial cancer patients. The study was published on June 16, 2015, in the British Journal of Cancer.
Related Links:
St James’s University Hospital
Biomarkers of systemic inflammation such as elevated neutrophil:lymphocyte ratio (NLR), platelet:lymphocyte ratio (PLR) and absolute monocyte counts have shown potential for guiding the clinical management of cancer patients across a range of malignancies including endometrial cancer.
Scientists at St James’s University Hospital (Leeds, UK) performed a retrospective study examining the records of a sequential series of 733 patients with a new diagnosis of primary endometrial cancer between January 2005 and December 2007. Patients’ full blood count data, including absolute leukocyte, neutrophil, eosinophil, basophil, monocyte, lymphocyte and platelet counts, were collected from a time frame of less than two weeks prior to hysterectomy and used to calculate NLR, PLR and monocyte:lymphocyte (MLR) ratios. The investigators chose to calculate MLR, the reciprocal of the more frequently used lymphocyte:monocyte ratio (LMR), to standardize by dividing myeloid lineage counts by lymphoid lineage cell counts for all relevant variables.
Full blood counts were performed on the Advia 2120 hematology analyzer (Siemens; Erlangen, Germany). The team applied cut-offs of greater than or equal to 2.4 (NLR), greater than or equal to 240 (PLR) and greater than or equal to 0.19 (MLR). NLR and PLR, but not MLR had independent prognostic significance. They combined NLR and PLR scores and stratified patients into low (NLR-low and PLR-low), intermediate (NLR-high or PLR-high) and high risk (NLR-high and PLR-high) groups. Increased NLR and PLR were most strongly associated with advanced stage, whereas increased MLR was strongly associated with older age. Both NLR and PLR were identified as having independent prognostic value when adjusted for age, stage, grade, lymphovascular space invasion and histopathological subtype.
The authors concluded that they have highlighted the potential of NLR and PLR as additional prognostic tools and despite their inter-relationships, both NLR and PLR proved to be better prognostic indicators than MLR in endometrial cancer. These are simple measures which are essentially cost-neutral and which could aid decision-making in the clinical management of endometrial cancer patients. The study was published on June 16, 2015, in the British Journal of Cancer.
Related Links:
St James’s University Hospital
Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
POCT Fluorescent Immunoassay Analyzer
FIA Go
New
Gold Member
Fully Automated Cell Density/Viability Analyzer
BioProfile FAST CDV
Latest Pathology News
- AI Integrated With Optical Imaging Technology Enables Rapid Intraoperative Diagnosis
- HPV Self-Collection Solution Improves Access to Cervical Cancer Testing
- Hyperspectral Dark-Field Microscopy Enables Rapid and Accurate Identification of Cancerous Tissues
- AI Advancements Enable Leap into 3D Pathology
- New Blood Test Device Modeled on Leeches to Help Diagnose Malaria
- Robotic Blood Drawing Device to Revolutionize Sample Collection for Diagnostic Testing
- Use of DICOM Images for Pathology Diagnostics Marks Significant Step towards Standardization
- First of Its Kind Universal Tool to Revolutionize Sample Collection for Diagnostic Tests
- AI-Powered Digital Imaging System to Revolutionize Cancer Diagnosis
- New Mycobacterium Tuberculosis Panel to Support Real-Time Surveillance and Combat Antimicrobial Resistance
- New Method Offers Sustainable Approach to Universal Metabolic Cancer Diagnosis
- Spatial Tissue Analysis Identifies Patterns Associated With Ovarian Cancer Relapse
- Unique Hand-Warming Technology Supports High-Quality Fingertip Blood Sample Collection
- Image-Based AI Shows Promise for Parasite Detection in Digitized Stool Samples
- Deep Learning Powered AI Algorithms Improve Skin Cancer Diagnostic Accuracy
- Microfluidic Device for Cancer Detection Precisely Separates Tumor Entities
Channels
Clinical Chemistry
view channel
3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models
Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more.jpg "Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)")
POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection
Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more
Highly Reliable Cell-Based Assay Enables Accurate Diagnosis of Endocrine Diseases
The conventional methods for measuring free cortisol, the body's stress hormone, from blood or saliva are quite demanding and require sample processing. The most common method, therefore, involves collecting... Read more
Molecular Diagnostics
view channel
Blood Proteins Could Warn of Cancer Seven Years before Diagnosis
Two studies have identified proteins in the blood that could potentially alert individuals to the presence of cancer more than seven years before the disease is clinically diagnosed. Researchers found... Read more (1)_1.jpg "Image: Ultrasound image of micro-histotripsy liberation of biomarkers in a tumor (Photo courtesy of Joy Wang and Pradyumna Kedarisetti)"){kind=small}
Ultrasound-Aided Blood Testing Detects Cancer Biomarkers from Cells
Ultrasound imaging serves as a noninvasive method to locate and monitor cancerous tumors effectively. However, crucial details about the cancer, such as the specific types of cells and genetic mutations... Read more_1.jpg "Image: The innovative method to customize and strengthen DNA origami structure promises breakthroughs in medicine (Photo courtesy of Shutterstock)")
.jpg "Image: The QIAstat-Dx Respiratory Panel Plus has received U.S. FDA clearance (Photo courtesy of QIAGEN)")
Immunology
view channel.jpg "Image: The AI predictive model identifies the most potent cancer killing immune cells for use in immunotherapies (Photo courtesy of Shutterstock)")
AI Predicts Tumor-Killing Cells with High Accuracy
Cellular immunotherapy involves extracting immune cells from a patient's tumor, potentially enhancing their cancer-fighting capabilities through engineering, and then expanding and reintroducing them into the body.... Read more
Diagnostic Blood Test for Cellular Rejection after Organ Transplant Could Replace Surgical Biopsies
Transplanted organs constantly face the risk of being rejected by the recipient's immune system which differentiates self from non-self using T cells and B cells. T cells are commonly associated with acute... Read more
AI Tool Precisely Matches Cancer Drugs to Patients Using Information from Each Tumor Cell
Current strategies for matching cancer patients with specific treatments often depend on bulk sequencing of tumor DNA and RNA, which provides an average profile from all cells within a tumor sample.... Read more
Genetic Testing Combined With Personalized Drug Screening On Tumor Samples to Revolutionize Cancer Treatment
Cancer treatment typically adheres to a standard of care—established, statistically validated regimens that are effective for the majority of patients. However, the disease’s inherent variability means... Read moreMicrobiology
view channel
Integrated Solution Ushers New Era of Automated Tuberculosis Testing
Tuberculosis (TB) is responsible for 1.3 million deaths every year, positioning it as one of the top killers globally due to a single infectious agent. In 2022, around 10.6 million people were diagnosed... Read more
Automated Sepsis Test System Enables Rapid Diagnosis for Patients with Severe Bloodstream Infections
Sepsis affects up to 50 million people globally each year, with bacteraemia, formerly known as blood poisoning, being a major cause. In the United States alone, approximately two million individuals are... Read more
Enhanced Rapid Syndromic Molecular Diagnostic Solution Detects Broad Range of Infectious Diseases
GenMark Diagnostics (Carlsbad, CA, USA), a member of the Roche Group (Basel, Switzerland), has rebranded its ePlex® system as the cobas eplex system. This rebranding under the globally renowned cobas name... Read more
Clinical Decision Support Software a Game-Changer in Antimicrobial Resistance Battle
Antimicrobial resistance (AMR) is a serious global public health concern that claims millions of lives every year. It primarily results from the inappropriate and excessive use of antibiotics, which reduces... Read morePathology
view channel
AI Integrated With Optical Imaging Technology Enables Rapid Intraoperative Diagnosis
Rapid and accurate intraoperative diagnosis is essential for tumor surgery as it guides surgical decisions with precision. Traditional intraoperative assessments, such as frozen sections based on H&E... Read more
HPV Self-Collection Solution Improves Access to Cervical Cancer Testing
Annually, over 604,000 women across the world are diagnosed with cervical cancer, and about 342,000 die from this disease, which is preventable and primarily caused by the Human Papillomavirus (HPV).... Read more
Hyperspectral Dark-Field Microscopy Enables Rapid and Accurate Identification of Cancerous Tissues
Breast cancer remains a major cause of cancer-related mortality among women. Breast-conserving surgery (BCS), also known as lumpectomy, is the removal of the cancerous lump and a small margin of surrounding tissue.... Read more
Technology
view channel
New Diagnostic System Achieves PCR Testing Accuracy
While PCR tests are the gold standard of accuracy for virology testing, they come with limitations such as complexity, the need for skilled lab operators, and longer result times. They also require complex... Read more
DNA Biosensor Enables Early Diagnosis of Cervical Cancer
Molybdenum disulfide (MoS2), recognized for its potential to form two-dimensional nanosheets like graphene, is a material that's increasingly catching the eye of the scientific community.... Read more
Self-Heating Microfluidic Devices Can Detect Diseases in Tiny Blood or Fluid Samples
Microfluidics, which are miniature devices that control the flow of liquids and facilitate chemical reactions, play a key role in disease detection from small samples of blood or other fluids.... Read more
Breakthrough in Diagnostic Technology Could Make On-The-Spot Testing Widely Accessible
Home testing gained significant importance during the COVID-19 pandemic, yet the availability of rapid tests is limited, and most of them can only drive one liquid across the strip, leading to continued... Read moreIndustry
view channel
Danaher and Johns Hopkins University Collaborate to Improve Neurological Diagnosis
Unlike severe traumatic brain injury (TBI), mild TBI often does not show clear correlations with abnormalities detected through head computed tomography (CT) scans. Consequently, there is a pressing need... Read more
Beckman Coulter and MeMed Expand Host Immune Response Diagnostics Partnership
Beckman Coulter Diagnostics (Brea, CA, USA) and MeMed BV (Haifa, Israel) have expanded their host immune response diagnostics partnership. Beckman Coulter is now an authorized distributor of the MeMed... Read more_1.jpg "Image: Thermo Fisher will distribute Bio-Techne products across Europe (Photo courtesy of 123RF)")
