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Pathology

Critical Enzyme Predicts Onset of Alzheimer Disease

The critical enzyme beta-secretase1 is known to be elevated in brains with sporadic Alzheimer disease and two of the major pathological characteristics of AD are neuritic plaques and neurofibrillary tangles, which are used to diagnose or confirm AD at autopsy.   More...
02 Jan 2014
Image: A linear ion trap - Fourier transform ion cyclotron resonance mass spectrometer (MALDI FTICR MS) similar to that used in the gastric cancer glycomics study (Photo courtesy of Wikimedia Commons).

Glycomic Analysis Distinguishes Gastric Cancer from Diseases with Similar Symptoms

Analysis of complex sugars in serum samples enabled diagnosticians to distinguish patients with gastric cancer from those with gastritis or duodenal ulcers.  More...
30 Dec 2013
Image: Bone marrow aspirate smear from a patient with chronic myelomonocytic leukemia, a myeloproliferative neoplasm (Photo courtesy of M.Yared).

Molecular Test Detects Difficult-to-Diagnose Chronic Blood Cancer

The current blood test used to diagnose blood cancer works by identifying mutation in a specific gene; however, it is not necessary that the gene should be present in every patient.  More...
26 Dec 2013
Image: Normal brain (left) compared with one from a severe case of Alzheimer’s disease (right) (Photo courtesy of US National Institute on Aging).

Rare Gene Variants Doubles Alzheimer's Disease Risk

Variations in a gene have been identified that doubles a person's risk of developing Alzheimer's disease later in life.    More...
26 Dec 2013
Image: Breast carcinoma HER2 (4B5) positive, Score: 3+ Magnification: 40X (Photo courtesy of Ventana).

HER2 Companion Diagnostic Test Helps Identify Patients for Two Additional Targeted Medicines

A new use of an HER2 assay can now also help identify breast cancer patients suitable for two additional HER2-targeted medicines, coinciding with therapy availability in many countries.  More...
25 Dec 2013
Image: The OncotypeDX Breast Cancer Assay (Photo courtesy of Genomic Health).

Genetic Signature Identifies Patients with Aggressive Triple-Negative Cancers

A genetic test has the potential to help physicians identify patients with the most lethal forms of triple-negative breast cancer, a disease that requires aggressive and innovative treatment.   More...
25 Dec 2013
Image: VENTANA Companion Algorithm ER (SP1) image analysis algorithm (Photo courtesy of Ventana).

US FDA Clears Estrogen Receptor Image Analysis and Digital Read Application for Breast Cancer

Software for estrogen receptor-analysis now completes the only FDA-cleared testing package providing five key breast cancer biomarkers with their corresponding image analysis algorithms and digital read applications.  More...
24 Dec 2013
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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