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Pathology

Molecular Urine Test Identifies Lung Carcinoma Mutations

The monitoring of circulating tumor DNA is a promising technique that may provide clinicians with a faster, cheaper and less invasive way to evaluate the clinical status and response to therapy of cancer patients. More...
20 May 2015

Automatic Cytometer Tallies Tumor Cells in Blood

Flow cytometry has been used to count cancer cells for many years, but the large instruments are expensive and can only be operated by trained personnel. More...
19 May 2015

Ovarian Cancer Screening Technique Doubles Detection Rates

A risk algorithm using serial biomarker measurements doubles the number of screen-detected ovarian cancers compared to a single threshold rule. More...
18 May 2015

Gene Mutation Test Diagnoses Myeloid Neoplasms

A wide range of gene mutations are associated with myeloid neoplasms, which occur when the bone marrow makes too many blood cells or platelets. More...
17 May 2015

$Image: Breast tissue stained to show hematoxylin and eosin (large tissue section). Two regions are selected to show an overlayer of molecular staining (left: cytokeratin; right: Masson\'s trichrome). All 3 stains were computationally generated using chemical imaging data obtained via a newly developed infrared spectroscopic imaging system, and without actually staining the tissue (Image courtesy of Prof. Rohit Bhargava, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign).$

Stainless Staining Provides New Histology Tool for Researchers and Clinical Pathologists

Researchers have developed a potentially revolutionary system based on infrared spectroscopic imaging that enables stain-free, non-perturbing, multiple analyses of a single biological tissue sample. More...
17 May 2015

Image: Telomeres at the end of the chromosomes protecting against DNA deterioration (Photo courtesy of Dr. Joseph Raffaele, MD).

Telomere Biomarker Blood Test Predicts Cancer Years In Advance

Telomeres are sequences of DNA on the ends of chromosomes that stop them fraying and losing their integrity, but they gradually shorten as one ages and by the time one grow up they are half the length they were when a person was born, then they halve again as they enter old age. More...
12 May 2015

Image: Estrogen receptor (ER)-positive breast cancer surgical pathology specimen stained for ER by immunohistochemistry. Most of the cancer cell nuclei stain dark brown, strongly positive for ER (Photo courtesy of Ronald S. Weinstein, MD).

Standard Clinical Assays Obscure Breast Cancer Subtype Diversity

The classification systems that categorize breast cancers based on estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression levels may obscure the heterogeneity of other key tumor features. More...
10 May 2015

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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.