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Pathology

Image: Histopathology of prostate cancer showing medium-sized cribriform gland with somewhat irregular luminal spaces (on left) that would be assigned Gleason pattern 4 (Photo courtesy of European Urology).

Prostate Cancer Diagnosed from Urinary Ribonucleic Acid

A test for noncoding ribonucleic acid molecules in urine may offer a way to detect prostate cancer that is more accurate and reliable than current methods using biomarkers such as prostate-specific antigen and prostate cancer gene 3.  More...
29 Mar 2016

Automated Microfluidic Device Simultaneously Detects HIV RNA and Antibodies

Diagnostic laboratories now have available a fully automated molecular testing device that simultaneously detects host anti-HIV antibodies and viral RNA in a single specimen of saliva or blood.    More...
27 Mar 2016
Image: Blood smear showing a segmented neutrophil and a mature lymphocyte with a single large nucleus (Photo courtesy of the University of Utah Medical School).

Early Stage Breast Cancer Recurrence Linked to High Leukocyte Ratio

A high ratio of two types of immune system cell is linked to an increased risk of disease recurrence after a diagnosis of early stage breast cancer and the findings might guide future treatment and monitoring strategies, if prospective studies confirm the link.  More...
23 Mar 2016
Image: Histopathology of the architecture of the lung in idiopathic pulmonary fibrosis (IPF) is characterized by a so-called “honeycomb” pattern with airways separated by bands of inflamed fibrous connective tissue and to a lesser extent, smooth muscle (Photo courtesy of Dr. Robert Dunstan).

Blood Test Accurately Detects Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis is a chronic, progressive and lethal lung disease characterized by scarring and reduction in the lungs' capacity to absorb oxygen. In the USA, around 100,000 people are currently affected by IPF, with approximately 30,000 to 40,000 new cases diagnosed each year.  More...
23 Mar 2016
Image: The Videssa Breast diagnostic test provides accurate early detection and typing of breast cancers by combining anatomical evidence from imaging with evidence from its proteomics test for proteins released into the blood system by cancer tumors (Image courtesy of Provista Diagnostics).

Age Should Be Considered in Developing Diagnostic Assays

In a new study on breast cancer, blood test results have demonstrated age-related differences in Tumor-Associated Antibodies, showing for the first time age-related differences that should be taken into consideration when developing diagnostic tests.  More...
23 Mar 2016
Image: Illustration of a protocol showing a pathway to develop core-shell nanoparticle/hybrid graphene oxide based multi-functional platform label-free SERS detection of β-amyloid toward developing a portable point-of-care blood test to monitor Alzheimer’s disease progression (Figure courtesy of Teresa Demeritt et al., 2015, ACS Appl. Mater. Interfaces; Copyright ACS-2015).

Developing POC Tests for Alzheimer’s to Improve Monitoring and Management of the Disease

Toward development of a portable point-of-care biosensor for Alzheimer’s disease, a new review explores recent advancements in nano-enabling electrochemical beta-amyloid-sensing technologies.  More...
22 Mar 2016
Image: Laser scanning confocal microscopy of clots constructed from adult fibrinogen (A), neonatal fibrinogen (B), or a mixture of the two (C). Scale bar= 20 μm (Photo courtesy of North Carolina State University).

Fibrin Network Changes in Neonates After Cardiopulmonary Bypass

Quantitative and qualitative differences in the hemostatic systems exist between neonates and adults, including the presence of “fetal” fibrinogen, a qualitatively dysfunctional form of fibrinogen that exists until one year of age.  More...
22 Mar 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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