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Pathology

Image: Photomicrograph of alveolar rhabdomyosarcoma showing nodules of tumor cells separated by hyalinized fibrous septae (50x, HE stain). Inset: Discohesive large tumor cells with hyperchromatic nucleus and scant cytoplasm (200x, HE stain) (Photo courtesy of Wikimedia Commons).

Five-Gene Panel Confirmed as Diagnostic for High-Risk Pediatric Rhabdomyosarcoma

A recently published paper confirmed the usefulness of a five-gene panel for identifying children with a high risk form of the muscle cancer rhabdomyosarcoma.  More...
27 Oct 2015
Image: The EGFR Mutation Test v2 was designed to run on a cobas 4800 instrument such as that shown here (Photo courtesy of Roche).

Liquid Biopsy Paves the Way for Personalized Lung Cancer Treatment

The biotech company Roche, an acknowledged leader in research-focused healthcare with combined strengths in pharmaceutical and diagnostic innovation, is focusing on the development of new tools for personalized lung cancer diagnostics and treatment.  More...
27 Oct 2015
Image: PointMan DNA enrichment technology for highly sensitive detection of genetic mutations (Photo courtesy of EKF Diagnostics).

DNA Enrichment Increases Usefulness of Liquid Biopsy Technology

DNA enrichment technology was a critical tool used in a study that detected genetic variations in circulating tumor cells in blood samples from non-small-cell lung cancer patients.  More...
27 Oct 2015
Image: Predicted secondary structure and sequence conservation of SNORA42 (Photo courtesy of Wikimedia Commons).

Elevated Levels of Small Nucleolar RNA Predict More Aggressive Colorectal Cancer

High levels of the small nucleolar RNA SNORA42 in patients with colorectal cancer have been shown to indicate that the patient may have a tumor that is especially aggressive, resistant to treatment, and prone to migrate and metastasize.  More...
26 Oct 2015
Image: Histopathology of pancreatic cancer showing a main-duct type intraductal papillary mucinous neoplasm (IPMN) with a focus of high-grade dysplasia compatible with malignant IPMN with carcinoma-in-situ (Photo courtesy of National Cancer Center. Singapore).

Noninvasive Blood Test Detects Pancreatic Cancer Biomarkers

For the prognosis of patients with pancreatic cancer, new biomarkers are required for earlier, pre-symptomatic diagnosis and as epigenetic mutations take place at the earliest stages of tumorigenesis and they offer new approaches for detecting and diagnosing disease.  More...
25 Oct 2015
Image: In Roche’s Cervical Cancer Screening Portfolio, the “CINtec p16 Histology” immunohistochemistry assay detects p16-INK4a in cervical biopsy preparations. The figure illustrates that in cells with transforming HPV infections, HPV viral oncoprotein E7 impairs the function of pRB, disrupting its ability to bind to E2F. This leads to deregulated cell proliferation, genetic instability, and p16 over-expression detectible by immunohistochemistry staining (Image courtesy of Ventana, of Roche).

Screening Portfolio Protects Patients from Cervical Cancer and Overtreatment

A new portfolio of clinically validated genetic and pathology tests for human papillomavirus cervical cancer screening and diagnosis helps identify women at high risk of developing this highly preventable disease, which is nevertheless still classified as the 4th most frequent cancer in women—530,000 new cases annually, of which about half the patients die.  More...
20 Oct 2015
Image: Histopathology of an adrenal incidentaloma showing the pushing border between the adenoma and the surrounding parenchyma (arrows) (Photo courtesy of the Government of Western Australia).

Novel Urinary Biomarkers May Indicate Adrenal Cancer

A global analysis of metabolites and small molecules in urine samples from patients with adrenal cancer has identified four biochemicals that, when measured together, can distinguish malignant from benign adrenal tumors.   More...
19 Oct 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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