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Pathology

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KRAS Mutation Test for Colorectal Cancer Diagnosis Approved

A real-time polymerase chain reaction test has been designed to identify the Kirsten rat sarcoma viral oncogene mutations in tumor samples from metastatic colorectal cancer patients and aid clinicians in determining a therapeutic path for them.  More...
27 May 2015
Image: Immunohistochemistry of stained estrogen receptor-positive breast cancer surgical pathology specimen (Photo courtesy of Dr. Ronald S. Weinstein, MD).

Second Pathology Analysis Ensures Proper Diagnosis and Treatment

A pathologic diagnosis is the foundation upon which all other treatment decisions are made with breast cancer and with the emergence of target therapy, the pathology dictates the use of potentially curable therapy.  More...
27 May 2015
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Small Molecule Detects Alzheimer's Disease at Early Stages

A high level of a small molecule called D-serine have been identified as associated with cognitive decline in Alzheimer’s disease and holds the potential to represent a novel and effective biomarker for AD.   More...
26 May 2015
Image: Histopathology of a spinal cord from an infant with multiple joint contractures present at birth (Photo courtesy of Dimitri P. Agamanolis, MD).

Infant Stiff-Joint Syndromes Matched to Possible Genetic Origins

There are over 400 specific disorders that are, or can be, associated with multiple contractures in the newborn and a better understanding of disorders with contractures and their associated genetics is critical for accurate diagnosis and optimal treatment.  More...
25 May 2015

Panel of Bloodstream MicroRNAs Predicts Damage from Radiation Exposure

A panel of microRNAs that can be measured in blood samples is able to predict the extent of long-term radiation injury and likelihood of survival following exposure to high doses of radiation.  More...
25 May 2015
Image: Left: Quantitative phase image of an unstained prostatectomy sample from a patient who had a biochemical recurrence of prostate cancer. Right: A zoomed-in region from the quantitative phase image showing a cancerous gland with debris in the lumen. The stroma, or supportive tissue environment, shows discontinuities in the fiber length and disorganization in the orientation of the fibers (Photo courtesy of the University of Illinois).

Pathologists Use Spatial Light Interference Microscopy to Predict Risk of Prostate Cancer Recurrence Prior to Biopsy or Surgery

A novel microscopy method that combines phase contrast microscopy with holography enables prediction of the likelihood of prostate cancer recurrence prior to biopsy or surgery.  More...
24 May 2015
Image: A user calibrates a newly developed portable polarimetric fiber stress sensor device while studying tumors by measuring Young’s modulus—an elasticity-related property recently linked to cancerous tumor aggressiveness (Photo courtesy of Kelvin Kuo, University of Southern California).

Portable Device Could Test for Physical Property of Tumor Aggressiveness

A new polarimetric fiber stress sensor device has been developed for visco-elastic and biomimetic material analysis, and, as part of the emerging field of physical oncology, is being tested for measuring a tumor’s Young’s modulus—an elasticity-related measure recently linked to cancerous tumor aggressiveness.  More...
24 May 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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