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Pathology

Image: In benign tissue next to a prostate tumor, the orientation of prostate glands, tends to be more uniform in those at low risk for biomedical recurrence but disordered among those at high risk (Photo courtesy of Case Western Reserve University).

Benign Tissue Structural Features Predict Risk of Prostate Cancer Recurrence Following Surgery

A preliminary study found that evaluation of a collection of structural features observed in normal tissues surrounding a prostate tumor was a better predictor of risk of recurrence of the cancer following surgical removal of the tumor by radical prostatectomy (RP). More...
18 Jul 2016
Image: An invasive adenocarcinoma (the most common type of colorectal cancer). The cancerous cells are seen in the center and at the bottom right of the image (blue). Near normal colon-lining cells are seen at the top right of the image (Photo courtesy of Wikimedia Commons).

Detection of Circulating Tumor DNA Predicts Colon Cancer Recurrence

A team of American and Australian cancer researchers has demonstrated that circulating fragments of tumor DNA (ctDNA) could serve as a biomarker for identifying patients with high risk of recurrence of colon cancer. More...
18 Jul 2016
Image: According to new research, a blood test that leads to donor hearts being rejected may not effectively predict whether a heart transplant will succeed or fail (Photo courtesy of the AMA).

Heart Transplantation Recipients Unaffected by Donor Troponin Levels

Many transplant centers routinely reject hearts if the donor’s blood test reveals elevated levels of troponin I, a protein found in heart muscle that enters the bloodstream when there is a heart attack or other heart muscle damage. Donors with previous heart disease are automatically excluded. More...
14 Jul 2016
Image: The E220 focused-ultrasonicator for DNA fragmentation (Photo courtesy of Covaris).

Genetic Causes of Bowel Cancer Clarified

Colorectal cancer (CRC) displays a complex pattern of inheritance and it is postulated that much of the missing heritability of CRC is enshrined in high-impact rare alleles, which are mechanistically and clinically important. More...
14 Jul 2016
Image: An adult deer tick Ixodes scapularis. Lyme disease is caused by Borrelia bacteria and transmitted to humans upon the bite of infected ticks of the genus Ixodes (Photo courtesy of Scott Bauer, Agricultural Research Service of USDA / Wikimedia).

Likely Flaws Uncovered for LM-Method for Lyme Disease Detection

According to a new study, the recently developed modified microscopy technique “LM-method” of examining blood samples to help diagnose Lyme disease (and babesiosis) – is unable to distinguish infected patients from healthy controls, yielding many false-positive results. More...
12 Jul 2016
Image: A micrograph of a prostate adenocarcinoma, acinar type, the most common type of prostate cancer. Needle biopsy, H&E stain (Photo courtesy of Nephron).

Urine Protein Panels Identify Prostate Cancer and Differentiate between Tumors

A noninvasive diagnostic test for prostate cancer is based on protein signatures that can differentiate patients from healthy individuals and those with aggressive tumors from those with less dangerous growths. More...
12 Jul 2016
Image: Researchers have devised a new high-resolution method for studying which genes are active in a tissue. The method can be used on all types of tissue and is valuable to both preclinical research and cancer diagnostics (Photo courtesy of the Karolinska Institutet / the Royal Institute of Technology).

Spatial Transcriptomics Technique Enables Visualization of Gene Expression in Tissues

A team of Swedish researchers has developed a high-resolution method for resolving the transcriptome – the library of active genes and RNAs – in histological samples of patients' tissues. More...
12 Jul 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.