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Pathology

Image: Assay principles: Unpurified PCR product is added to a micro well containing probe-conjugated microbeads. A wild-type target hybridizes efficiently to both probes, inducing bead aggregation. Hybridization of a mutant target to the discriminating probe is unfavorable; therefore, the beads remain dispersed. An image of each micro well is obtained and processed to generate a saturation value corresponding to the extent of aggregation (Photo courtesy of The Journal of Molecular Diagnostics).

Rapid Technique Described for Detection of KRAS Mutations in Pathology Specimens

A recent paper described a rapid and inexpensive method for detecting KRAS mutations in clinical biopsy specimens of lung and colorectal cancers. More...
20 Jun 2016
Image: The AbsoluteIDQ p180 Kit for Metabolic Phenotyping (Photo courtesy of Biocrates Life Sciences).

Blood Metabolites Tests Helps Tailor Cancer Treatment

As a minimally invasive assessment, plasma metabolomic analysis has the potential to complement direct tumoral measurements and, particularly where cancer biopsies are unavailable, and can report on the integrated output of multiple systems including sites of disease. More...
15 Jun 2016
Image: The cobas epidermal growth factor receptor EGFR Mutation Test v2 (Photo courtesy of Roche Molecular Systems).

Blood Test Detects Gene Mutation Associated with Lung Cancer

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and NSCLC tumors may shed tumor DNA into a patient's blood, making it possible to detect specific mutations in blood samples. More...
14 Jun 2016
Image: A diagram of Merkel cell polyomavirus preferentially infecting dermal fibroblasts in human skin (Photo courtesy of Jianxin You, PhD).

Merkel Cell Polyomavirus Infection Can Cause Lethal Carcinoma

A benign virus normally found in the skin can lead to a type of rare, lethal skin cancer; specifically, infection by the Merkel cell polyomavirus can lead to Merkel cell carcinoma in immune-compromised individuals. More...
14 Jun 2016
Image: The ability of cancer cells to move and spread depends on actin-rich core structures such as the podosomes (yellow) shown here in melanoma cells. Cell nuclei (blue), actin (red), and an actin regulator (green) are also shown (Photo courtesy of Julio C. Valencia and Daniel Mietchken, via Wikimedia).

Early Detection Among Benefits of Skin Cancer Screening at Primary Care Visits

According to new research, skin cancer screenings performed by primary care physicians (PCPs) during routine office visits improves detection of potentially deadly melanomas and find them in earlier stages. More...
13 Jun 2016
Image: The MiSeq desktop sequencer (Photo courtesy of Illumina).

Primary Sclerosing Cholangitis Characterized By Intestinal Dysbiosis

Primary Sclerosing Cholangitis also known as PSC, is a liver disease with no effective medical treatment and liver transplantation is the only proven long-term treatment of PSC, although only a fraction of individuals with PSC will ultimately require it. More...
08 Jun 2016
Image: A photomicrograph of placental tissue revealing the presence of the malarial parasites. The blue arrows point to examples of red blood cells containing pigment and the black arrow points to an example of a pigment-containing histiocyte (Photo courtesy of Drucilla J Roberts, MD).

Placental Malaria Diagnosed In Poorly Processed Placental Tissue

Placental histopathology has been considered the gold standard for diagnosis of malaria during pregnancy; however, in under-resourced areas placental tissue is often improperly fixed and processed; the resulting formalin pigment is difficult to distinguish from malaria pigment. More...
08 Jun 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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