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Pathology

Image: (a) A scanning electron micrograph (SEM) of vaginal fluid from a woman with bacterial vaginosis and high concentrations of bacterial vaginosis associated bacterium 1 (BVAB1); (b) These cells are different from the larger, wider, and more electron dense curved rods observed in a pure culture of Mobiluncus curtisii (Photo courtesy of the US National Library of Medicine).

Premature Birth Risk Linked to Bacteria in Cervicovaginal Space

Changes in microbial communities have been implicated in both health and disease and investigations into the association between the cervicovaginal (CV) microbiota and spontaneous preterm birth (SPTB) have been limited in scope and number. More...
17 Feb 2017
Image: The new quantitative multiplex assay (cMethDNA) (Photo courtesy of Johns Hopkins Kimmel Cancer Center).

Tumor DNA Blood Test Predicts Advanced Breast Cancer Survival

A blood test that spots cancer-linked DNA correctly predicted that most of those patients with higher levels of the tumor markers died significantly earlier than those with lower levels. More...
16 Feb 2017
Image: Pathogenic mutations identified with a multigene panel among 1,058 individuals with colorectal cancer (Photo courtesy of American Society of Clinical Oncology).

Broader Genetic Testing Recommended for Colorectal Cancer Risk

An expanded role for genetic testing of inherited risk has been recommended, both to help in treating people with colorectal cancer and in preventing their at-risk family members from developing it. More...
16 Feb 2017
Image: The fully automated ThunderStorm High-throughput Next-generation Target Enrichment system (Photo courtesy of RainDance Technologies).

Urinary Biomarker Assay Detects Bladder Cancer

A new test for bladder cancer could enable general practitioners to test a urine sample and spare patients the discomfort of a cystoscopy in hospital which is the gold standard test for the detection of bladder cancer, but it is operator-dependent with a sensitivity of 90% to 97%. More...
16 Feb 2017
Image: A structural model of human prostate specific antigen (PSA) with bound substrate complexed with antibody (Photo courtesy of Wikimedia Commons).

Genome Study Strengthens Value of PSA Screening as Diagnostic Tool

Results of a genome-wide association study (GWAS) of prostate specific antigen (PSA) may lead to improvements that will increase the usefulness of measuring this biomarker for diagnosis of prostate cancer. More...
14 Feb 2017
Image: The Biomark microfluidic system for polymerase chain reactions (Photo courtesy of Fluidigm).

Blood Test Monitors Relapsed Serous Ovarian Cancer

The development of blood biomarkers that can be used for early detection of cancer or to measure tumor burden and response to treatment is a major goal of translational cancer studies across all cancer types. More...
09 Feb 2017
Image: MiR-194 drives prostate cancer metastasis by suppressing SOCS2 activity (Photo courtesy of Dr. Luke Selth, University of Adelaide).

Blood Levels of Specific MicroRNA Predict Likelihood of Metastasis

The microRNA (miRNA) that regulates the activity of the ubiquitin ligase enzyme SOCS2 (Suppressor of Cytokine Signaling 2) has been linked to the ability of prostate cancer to metastasize. More...
08 Feb 2017
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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