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Pathology

Image: A genetic variant within the gene for protein tyrosine phosphatase receptor-type delta (PTPRD) has been associated to susceptibility to neurofibrillary tangles, which are thought to be more closely related to memory decline than other forms of aging-related brain pathologies (Photo courtesy of Rush University).

Gene Discovered Associated with Aging Brain Pathologies

Investigators have discovered a gene associated with susceptibility to the common Tau form of brain pathology that accumulates in several different conditions, including Alzheimer’s disease, certain forms of dementia, and Parkinsonian syndromes, as well as chronic traumatic encephalopathy that occurs with repeated head injuries. The gene and its product may serve as a marker for loss of brain function with advancing age, and as a potential drug therapy target. More...
04 Apr 2017
Image: A melanoma on a patient\'s skin (Photo courtesy of the National Cancer Institute).

Fine-Tuned Microscopy Offers Breakthrough Resolution of Melanoma

Researchers have refined a classic Raman-based technique and succeeded in imaging the two dominant melanin molecules, which could lead to new understandings and, critically, early detection of melanoma. More...
17 Mar 2017
Image: The pituitary-specific transcription factor PIT-1 plays an essential role in producing growth hormone (GH), thyroid stimulation hormone (TSH), and prolactin (PRL). Researchers have discovered that a thymoma was detected in examined cases of “anti-PIT-1 antibody syndrome”. PIT-1 expression was abnormally increased within the thymoma and this likely evoked the immune tolerance breakdown and hypopituitarism that occurs in patients with this autoimmune disorder (Photo courtesy of Kobe University).

Autoimmune Disease Trigger Associated with Thymoma Tumors

Researchers have discovered that a newly-identified autoimmune endocrine disease – “Anti-PIT-1 antibody syndrome” – that leads to hypopituitarism is likely caused by overexpression of PIT-1 in the thymoma type of tumor originating from the thymic gland. More...
16 Mar 2017
Image: A structural model of amyloid precursor protein (APP) (Photo courtesy of Wikimedia Commons).

Study Identifies Gene Variants Linked to AD in African Americans

In what may have been the first comprehensive screening of rare coding variants in an African American population, researchers identified several rare gene variants linked to the development of early onset Alzheimer's disease (AD). More...
08 Mar 2017
Image: A histopathogic image of pancreatic adenocarcinoma arising in the pancreas head region (Photo courtesy of Wikimedia Commons).

Diagnosing Pancreatic Cancer Early Enough for Surgical Treatment

A team of pancreatic cancer researchers has found that by combining measurement of two blood biomarker proteins with determination of the current gold standard biomarker, CA 19-9, it was possible to detect pancreatic cancer at an early enough stage to save patients with surgery. More...
08 Mar 2017
Image: A diagram showing lung cancer’s “field of injury” extends well beyond the tumor. New research demonstrates genetic changes in nasal cells of patients who went on to develop lung cancer (Photo courtesy of Avrum Spira, Boston University Medical Center).

Samples Reveal Gene Expression Pattern Diagnostic for Lung Cancer

Differences in gene expression that can be detected in nasal tissue from smokers or nonsmokers suggest that it may be possible to diagnose lung cancer from samples collected on nasal swabs. More...
08 Mar 2017
Image: A scanning electron micrograph (SEM) of dividing colorectal cancer cells (Photo courtesy of MNT).

Panel Establishes Biomarker Guidelines for CRC Diagnostics

After reviewing more than 4,000 articles, an expert panel has issued recommendations for testing diagnostic biomarkers in patients with early and advanced colorectal cancer. More...
07 Mar 2017
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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