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Pathology

Image: The NextSeq 500 benchtop sequencer delivers on-demand exome, transcriptome and whole-genome sequencing (Photo courtesy of Illumina).

Distinct Epigenetic Features Found in Alzheimer's Brains

Aging is the strongest risk factor for Alzheimer’s disease (AD), although the underlying mechanisms remain unclear though AD tends to coincide with certain chromatin shifts in the aging brain. More...
21 Mar 2018
Image: Extracellular vesicles (red) released from a patient’s tumor and captured on the surfaces of the EVHB-Chip (Photo courtesy of Professor Shannon Stott, PhD).

Microfluidic Device Captures Tumor-Specific Extracellular Vesicles

A microfluidic device has been developed that can capture glioblastoma-derived extracellular vesicles, with high specificity, using very small blood samples, which would be useful for pediatric patients. More...
21 Mar 2018
Image: The CellDetect platform is the only histochemical solution providing color discrimination between normal, pre-cancer and cancer cells alongside morphological examination (Photo courtesy of Micromedic Technologies).

Non-Invasive Urine Test Detects Prostate Cancer

Prostate cancer is the second most common cancer among men worldwide. About one man in nine will be diagnosed with prostate cancer during his lifetime. It is estimated that in the USA for 2018 there will be about 165,000 new cases of prostate cancer and about 29,000 deaths from prostate cancer. More...
15 Mar 2018
Image: The QX200 AutoDG automated droplet generator, part of the Bio-Rad QX200 PCR System (Photo courtesy of Compass Design).

Blood Test Predicts Patient Response to Chemotherapy

Early changes in circulating tumor DNA (ctDNA) level may provide early response prediction, but the impact of tumor heterogeneity is unknown. More...
14 Mar 2018
Image: The automated NanoString nCounter system provides a direct measurement of gene expression using a novel digital color-coded barcode technology (Photo courtesy of the Fred Hutchinson Cancer Research Center).

Elevated Mir-24-3p Plays Prognostic Role in Breast Cancer

Breast cancer is the most common malignancy in women. In 2018 an estimated 266,120 new cases of invasive breast cancer are expected to be diagnosed in women in the USA, along with 63,960 new cases of non-invasive breast cancer. Therefore, there is a need to identify novel prognostic and predictive markers of occult metastases to better individualize adjuvant systemic therapy. More...
12 Mar 2018
Image: A new technique to isolate cancer stem cells: 40,000 tiny plastic beads (blue),were used each coated with a unique chemical compound, to identify one compound that bound only to breast cancer stem cells (red) (Photo courtesy of the University of Texas at Dallas).

Cancer Stem Cells Isolated Using Novel Method

Stem cells are in various tissues in the body, and unlike regular cells, which have a limited lifespan; they can divide and renew themselves for long periods of time.  More...
07 Mar 2018
Image: These were created using the new staining method: A: Micro-CT image of a mouse kidney, B: Nano-CT image of the same tissue (Photo courtesy of the Technical University of Munich).

New Staining Method Enables Nano-CT Imaging of Tissue

Tissue sectioning is a routine procedure in hospitals, for instance to investigate tumors. As the name implies, it entails cutting samples of body tissue into thin slices, then staining them and examining them under a microscope. More...
07 Mar 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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