Pathology

$Image: An evaluation of RP expression specificity across human tissues, primary cells, and tumors (Photo courtesy of University of Basel\'s Biozentrum).$

Ribosomal Protein Expression Specifies Normal and Malignant Human Cells

Proteins are the building blocks of life, produced by molecular machines called ribosomes. A human ribosome is composed of four ribosomal RNAs (rRNAs) and 80 ribosomal proteins (RPs), and its structure is believed to be largely invariant. More...
29 Dec 2016

Image: A histopathology of cerebral glioblastoma showing marked cellularity, with marked hyperchromatism and pleomorphism. Note the prominent vascularity as well as the area of necrosis at the left with neoplastic cells palisading around it (Photo courtesy of KGH).

Gene Identified That Drives Deadly Brain Cancer

Glioblastoma is the most common and aggressive brain cancer in adults and over 70% of patients with glioblastoma die within two years of diagnosis, though a gene has been identified that is overactive in a deadly form of brain cancer. More...
29 Dec 2016

Image: A histology of immune cells of the brain, the microglia (brown), cluster around the beta-amyloid deposits (red) in an Alzheimer’s disease model (Photo courtesy of Frank Heppner/ Charité).

Early Signs of Alzheimer's Detected in Cerebrospinal Fluid

An early immune response has been found in individuals with a genetic predisposition to Alzheimer's and their brains showed abnormal immune reactions as early as about seven years before the expected onset of dementia. More...
29 Dec 2016

Image: Sample application for the VeriStrat proteomic serum test for advanced non-small-cell lung cancer which helps physicians determine whether a patient should receive treatment with an epidermal growth factor receptor inhibitor (Photo courtesy of Biodesix).

Proteomic Test Stratifies Patients for Immunotherapies

Anti PD-1 inhibitors are the treatments of choice in second line non-small cell lung cancer (NSCLC), however they only benefit a fraction of patients, while existing biomarkers such as PD-L1 expression correlate with outcomes, but are not sufficient to guide therapy. More...
28 Dec 2016

Serum MiR-122 Levels Associated with Histopathological Features of NAFLD

Non-alcoholic steatohepatitis (NASH) can only be diagnosed by the presence of histopathological components, such as steatosis, lobular inflammation, ballooning, and fibrosis and therefore there is a need for non-invasive surrogate markers of histopathological features. More...
28 Dec 2016

Image: A fluorescent micrograph of Streptococcus pneumoniae in spinal fluid (Photo courtesy of the CDC).

Pneumococcal Immune Status Accurately Determined in Saliva Samples

Measurement of levels of antibodies against 12 Streptococcus pneumoniae antigens in saliva was shown to provide as accurate an indication of immune status against this organism as was determination of antibody levels in blood serum. More...
27 Dec 2016

$Image: Research suggests that following the levels of antibodies directed against the human papilloma virus\' E6 and E7 proteins could be an accurate method for predicting whether a patient being treated for oropharyngeal cancer will experience recurrence of the disease (Photo courtesy of Medscape).$