Pathology
Jagged Ends of Urinary Cell-Free DNA Assessed in Bladder Cancer Detection
Bladder cancer is where a growth of abnormal tissue, known as a tumor, develops in the bladder lining. In some cases, the tumor spreads into the bladder muscle. The most common symptom of bladder cancer is blood in the urine, which is usually painless. More...24 May 2021
Loss of Function Mutations in GEMIN5 Cause a Neurodevelopmental Disorder
GEMIN5, an RNA-binding protein is essential for assembly of the survival motor neuron (SMN) protein complex and facilitates the formation of small nuclear ribonucleoproteins (snRNPs), the building blocks of spliceosomes. More...20 May 2021
Human Microbiota Flagellins Drive Adaptive Immune Responses in Crohn’s Disease
Crohn's disease and ulcerative colitis, another type of inflammatory bowel disease (IBD), are characterized by dysregulated adaptive immune responses to the microbiota in genetically susceptible individuals, but the human specificity of these responses had so far been largely undefined. More...20 May 2021
Rapid, Direct-to-Digital Prostate Biopsy Pathology Evaluated
Increasing adoption of digital pathology promises marked improvements in reproducibility, efficiency, and accuracy of tissue-based diagnostics by facilitating routine remote expert consultation and enabling computerized image analysis for clinical use. More...13 May 2021
Developed Immunoassay Predicts Benefits of Anti-PD-1 Therapy in NSCLC
Lung cancer is the most common cause of cancer-related deaths worldwide. However, current targeted therapies and immunotherapies have gradually improved patient survival. Anti-programmed cell death-1 (PD-1) antibodies (Abs) are key drugs in non-small-cell lung cancer treatment; however, clinical benefits with anti-PD-1 monotherapy are limited. More...12 May 2021
Holographic Histopathology Enables Fast, Precise Diagnostics
Microscopic assessment of biopsied and resected tissues is central to understanding the underlying pathophysiology and clinical states of many patients. Because most microscopic specimens are translucent to visible light, conventional histological methods achieve image contrast using exogenous labels. More...10 May 2021
Genetic Background and Clinicopathologic Features Established for Adult-Onset Nephronophthisis
Nephronophthisis (NPH) is a genetic disorder of the kidneys which mainly affects children. It is classified as a medullary cystic kidney disease. The disorder is inherited in an autosomal recessive fashion and, although rare, is the most common genetic cause of childhood kidney failure. More...06 May 2021
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In Other News
African-American MS Patients Experience More Rapid B-Cell Repopulation
GPS Assay Associated with Long-Term Prostate Cancer Outcomes
New Genetic Factors Involved in Sudden Unexpected Death in Children
Altered Perivascular Fibroblast Activity Precedes ALS Disease Onset
RNA-Sequencing Predicts Immunotherapy Success in Bladder Cancer
Tissue Counterpart to Monoclonal B-Cell Lymphocytosis Characterized
Breast Cancer Histopathology Employs Infrared Spectroscopic Imaging
Coagulation Dysfunction and Infection Evaluated in Patients with AECOPD
Spatial Landscape of Lung Pathology Investigated During COVID-19 Progression
Leukocyte Epigenomics and Artificial Intelligence Predict Late-Onset Alzheimer’s Disease
Single-Cell Transcriptomic Analysis Traces Neuroblastomas to Developing Adrenal Neuroblasts
Whole-Genome Sequencing Aids Rare Disease Diagnosis
Calcitonin and Procalcitonin Immunoassays Investigated for Medullary Thyroid Carcinoma
Immune Cells in Cerebrospinal Fluid Predict Response to Immunotherapy
Pediatric Pancreatic Cancer Diagnosed From cfDNA Fragments in Urine
CSF Biomarker Flags Parkinson's Pathology Much Earlier
Five Genes Help Predict Lewy Body Dementia
Clinical Germline Testing Evaluated for Pediatric Cancer Patients
Genetic Risk of Inflammatory Bowel Disease Appears Distinct in African Americans
ctDNA Provides Prognostic Clues in Advanced BRAF-Mutated Melanoma Cases
22-Gene Genomic Classifier Validated in Recurrent Prostate Cancer Patients
Blood Biomarker Predicts Dementia in Cerebral Small Vessel Disease
Proteogenomic And Metabolomic Studies Characterize Human Glioblastoma
The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
