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Pathology

Image: A sample collection kit for the expanded Multi-Cancer 83-gene comprehensive panel that increases diagnostic yield. Germline testing after tumor sequencing uncovers clinically actionable variants (Photo courtesy of Invitae).

Germline Testing After Tumor Sequencing Uncovers Clinically Actionable Variants

Genetic counseling and germline testing are recommended for patients with cancer who have suspected hereditary disease based on each patient’s presentation and family history. Separately, tumor DNA sequencing is increasingly used, most often in patients with advanced disease. More...
27 Oct 2020
Image: Circulating tumor cells (CTCs) are cancer cells that are released and disseminated into the bloodstream and lymphatic system. CTC cultures were successfully propagated from breast epithelial cells (Photo courtesy of Menarini Silicon Biosystems).

Novel CTC Culture Method Developed to Study Metastatic Cancer

Cancer metastasis is responsible for most cancer-associated death. During metastasis, cells that escape the primary tumor into the circulatory system are known as circulating tumor cells (CTCs). More...
26 Oct 2020
Image: Photomicrograph of histology of a Ewing sarcoma in lung. The PAS stain highlights glycogen and the staining was negative with a PAS diastase stain (Photo courtesy of Nephron).

Comprehensive Molecular Profiling Matches Pediatric Patients to Therapies

A major challenge of using a comprehensive profiling approach for precision medicine is separating pathogenic from non-pathogenic molecular changes within a tumor. More...
22 Oct 2020
Image: The HiSeq XTen human whole- genome sequencing system (Photo courtesy of Illumina).

Urine-Based Liquid Biopsy Test Detects Urothelial Carcinoma

Urine cytology, which is widely used to screen for bladder cancer, has high specificity but lacks sensitivity, especially for low-grade cancers. Cystoscopy, while more accurate than cytology, is an invasive procedure with added costs and potential complications for the patient. More...
22 Oct 2020
Image: Breath test developed for head and neck cancer diagnosis used a selected ion flow-tube mass spectrometer (Photo courtesy of Syft Technologies).

Breath Test Developed for Head and Neck Cancer Diagnosis

Breath testing is a noninvasive way to help doctors diagnose a number of conditions. By analyzing the breath, the physicians can measure the amount of certain gases, allowing doctors to arrive at a diagnosis quickly and accurately. More...
20 Oct 2020
Image: Photomicrograph showing tumor-infiltrating lymphocytes in colorectal carcinoma which are suggestive of microsatellite instability (Photo courtesy of Nephron)

Lymphocytic Infiltration Explored as Biomarker for Stable Colorectal Tumors

Identifying stage II patients with colorectal cancer (CRC) at higher risk of progression is a clinical priority in order to optimize the advantages of adjuvant chemotherapy while avoiding unnecessary toxicity. A remarkable feature of CRC is the difference in prognosis of patients diagnosed at early versus late stages of the disease. More...
15 Oct 2020
Image: Photomicrograph of histopathology of hepatocellular carcinoma, the most common form of primary liver cancer, showing end-stage cirrhosis - blue collagen (fibrosis) Mallory bodies; loss of normal liver architecture; and nuclear atypia. (Photo courtesy of Nephron).

Hematological Biomarkers Predict Prognosis in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is an inflammation-related cancer, where non-resolving inflammation contributes to its development and progression. Peripheral inflammatory cells have been shown to be associated with the prognosis of various types of cancer. More...
12 Oct 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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