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Technology

Image: Newly designed bacteria with synthetically rewired genetic circuitry act as bactosensors to detect abnormal glucose levels in urine of diabetes patients (Photo courtesy of Chris Bickel and the journal Science).

Next-Generation Whole-Cell Biosensors May Provide New Approach to Diagnostics

Researchers have developed the first programmable bacterial cells for medical diagnosis with improved computing and amplification capacity that could enable earlier clinical detection of various pathological biomarkers in urine or blood.  More...
08 Jun 2015
Image: Schematic of the antibiotic susceptibility testing device. Bacteria are cultured in miniature chambers, each of which contains a filter for bacterial capture and electrodes for readout of bacterial metabolism (Photo courtesy of the University of Toronto).

Microchip Device for One Hour Antibiotic Resistance Testing

A novel electrochemical approach – designed to replace growth or fluorescent tests for drug resistance – can determine within one hour whether a culture of bacteria is susceptible to a particular antibiotic.   More...
08 Jun 2015
Image: The centrifugation step is the key to removing protein biomarkers from urine\'s high salt matrix (Photo courtesy of Clemson University).

Rapid Extraction Technique Prepares Urine Samples for Mass Spectrometry Analysis

Disposable mini-tubes packed with capillary-channeled polymer fibers have been adapted for the rapid extraction of proteins from urine specimens for analysis by MALDI-MS.  More...
07 Jun 2015
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Microfluid Chip Traps Migrating Tumor Cell Clusters

A microfluidic chip has been developed that can capture rare clusters of circulating tumor cells, which could yield important new insights into how cancer spreads. More...
01 Jun 2015
Image: The cobas Liat System, a fast, easy-to-use, compact PCR system (Photo courtesy of Roche).

Rapid Strep A PCR Test Approved for Use outside Traditional Clinical Labs

A 15-minute diagnostic test for the detection of Streptococcus A in throat cultures that was designed to be run on a user-friendly, automated PCR platform has been granted a CLIA waiver from the [US] Food and Drug Administration.  More...
01 Jun 2015
Image: Mycobacterium tuberculosis (stained purple) in a tissue specimen (blue) (Photo courtesy of the CDC – [US] Centers for Disease Control and Prevention).

New Method for Genome Analysis of Drug Resistant Tuberculosis Bacteria Directly from Patient Samples

A European research consortium has developed a test for the detection of drug resistant strains of the tuberculosis bacterium Mycobacterium tuberculosis, which yields results within a few days rather than the period of weeks that is required by current methods.  More...
25 May 2015
Image: Left: Quantitative phase image of an unstained prostatectomy sample from a patient who had a biochemical recurrence of prostate cancer. Right: A zoomed-in region from the quantitative phase image showing a cancerous gland with debris in the lumen. The stroma, or supportive tissue environment, shows discontinuities in the fiber length and disorganization in the orientation of the fibers (Photo courtesy of the University of Illinois).

Pathologists Use Spatial Light Interference Microscopy to Predict Risk of Prostate Cancer Recurrence Prior to Biopsy or Surgery

A novel microscopy method that combines phase contrast microscopy with holography enables prediction of the likelihood of prostate cancer recurrence prior to biopsy or surgery.  More...
24 May 2015
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LabMedica's Lab Technology channel informs on laboratory medicine techniques, while keeping an eye on new hardware, LIM software, consumables, and lab trends, techniques and safety.