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Immunology

Antisynthetase Syndrome Patients with positive immunohistochemistry reaction of (A) YKL-40, (B) YKL-40 (higher magnification); (C), a specimen from a patient with antisynthetase syndrome, but without infiltrate inflammation; (D) CD68, (E) CD4, and (F) CD8 (Photo courtesy of Universidade de Sao Paulo).

Serum YKL-40 Levels Measured In Antisynthetase Syndrome Patients

Antisynthetase syndrome (ASSD) is a rare systemic autoimmune myopathy characterized by muscle, joint, and pulmonary involvement, as well as by the presence of fever, “mechanic’s hands,” and Raynaud’s phenomenon. More...
10 Aug 2021
A novel protein-based multitarget fecal immunochemical test (mFIT) for colorectal cancer (CRC) screening was superior to conventional FIT in detecting advanced neoplasia, particularly advanced adenomas (Photo courtesy of Mike Bassett)

Multitarget Fecal Immunochemical Test Validated for Colorectal Cancer

Colorectal cancer (CRC) starts in the colon or the rectum. These cancers can also be called colon cancer or rectal cancer, depending on where they start. Colon cancer and rectal cancer are often grouped together because they have many features in common. More...
08 Aug 2021
The Invitrogen Human EGF ELISA Kit measures levels of epidermal growth factor (EGF) in human serum, plasma, and cell culture supernatant using 96-well plates (Photo courtesy of Thermo Fisher Scientific)

Urinary Epidermal Growth Factor Investigated for Diabetes Nephropathy

Type 1 diabetes mellitus is an auto-immune metabolic disease with chronic hyperglycemia. For many patients with type 1 diabetes (T1DM), it is challenging to maintain near-normal glucose blood levels and to reduce the risk of both acute (hypoglycemia, ketoacidosis) and chronic microvascular (retinopathy, neuropathy and nephropathy) and macrovascular complications. More...
06 Aug 2021
Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease (Photo courtesy of Massachusetts General Hospital)

Microbiome and Metabolic Features Tied to IBD Treatment Response

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Crohn's disease and ulcerative colitis are the principal types of inflammatory bowel disease. More...
06 Aug 2021
Image: Immunoscreening of TIA antigens by SEREX. Bacterial proteins including phage cDNA products were blotted on nitrocellulose membranes and reacted with the sera of patients with transient ischemic attack (TIA); arrows indicate positive phage clones (Photo courtesy of Chiba University)

ALDOA and FH4 Antibodies Associated with Cerebrovascular Disease

Ischemic stroke, including transient ischemic attack (TIA) and cerebral infarction (CI), is the most globally recognized cerebrovascular disorder, and is a serious health problem in the aging society. CI is an episode of neurological dysfunction caused by focal brain infarction, often resulting in fatality and disability. Patients with TIA are at a high risk of CI. More...
28 Jul 2021
Image: The AU5800 Clinical Chemistry Analyzer is an automated chemistry analyzer that measures many different chemical analytes (Photo courtesy of Beckman Coulter)

Differential Biochemical Markers Identified in Inflammatory Processed Synovial Fluid

Joint infections with a non-specific presentation are difficult to diagnose, mainly due to the absence of specific clinical signs and symptoms, relative lack of accurate laboratory tests, low virulence due to previous treatment, and biofilm ability of the pathogens. More...
28 Jul 2021
Image: Immunohistochemical (IHC) analysis of the normal tissue from a healthy subject showed several Matrix Metalloproteinase-13 (MMP-13) positive cells (light brown staining indicated by the red arrow in panel a. Panel b is an IHC microphotograph for the cSCC tissue, and brown staining can be seen in most of tumor cells (Photo courtesy of Weifang People’s Hospital)

Diagnostic Biomarker MMP-13 Explored for Cutaneous Squamous Cell Carcinoma

Cutaneous basal cell carcinoma (cBCC) and cutaneous squamous cell carcinoma (cSCC) account for approximately 80% and 20% of non-melanoma skin cancer (NMSC), respectively Although the majority of cSCCs are successfully eradicated by surgical excision, a subset of cSCC possesses features associated with a higher likelihood of recurrence, metastasis, and death. More...
27 Jul 2021
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.