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Immunology

Image: Photomicrograph of cytomegalovirus colitis (Photo courtesy of Nephron)

Immunohistochemistry Evaluated for Tissue-Invasive Cytomegalovirus in Gastrointestinal Mucosal Biopsies

Cytomegalovirus (CMV) immunohistochemistry (IHC) is the most widely used method to diagnose CMV infection/reactivation in tissues in a pathology laboratory. More...
04 Mar 2022
Image: ARCHITECT i2000SR Automatic immunoassay analyzer / chemiluminescence (Photo courtesy of Abbott)

Low Levels of IL-39 Associated With Autoimmune Thyroid Disease

Interleukin (IL)-39 is a novel member of IL-12 cytokine family, but its role in autoimmune thyroid diseases (AITD) is unclear. The aim of the present study was to determine serum levels of IL-39 in Hashimoto's thyroiditis (HT) and Graves' disease (GD) patients. More...
03 Mar 2022
Image: Schematic diagram of the IMMray PanCan-d assay that relies on the IMMray microarray technology, where single chain fragment antibodies are printed onto a slide in a measured amount as a microarray of different antibody biomarkers (Photo courtesy of Immunovia)

Immunoassay Detects Pancreatic Cancer in People at High Risk

An immunoassay was able to detect pancreatic cancer in high-risk individuals and with high sensitivity and specificity. More...
28 Feb 2022
Image: The ABI PRISM 3100 Genetic Analyzers is an automated capillary electrophoresis systems that can separate, detect, and analyze fluorescent-labeled DNA fragments in one run (Photo courtesy of Michaela Pereckas)

Chromosomally Normal Miscarriage Is Associated With Vaginal Dysbiosis

Emerging evidence supports an association between vaginal microbiota composition and risk of miscarriage; however, the underlying mechanisms are poorly understood. We aim to investigate the vaginal microbial composition and the local immune response in chromosomally normal and abnormal miscarriages and compare this to uncomplicated pregnancies delivering at term. More...
17 Feb 2022
Illustration

Novel Immune-Profiling Method Reports Specific Immune Cell Types Using Only DNA from Blood

A novel immune-profiling method can return detailed immune cell type proportions using only DNA from blood with no requirement for intact cells, potentially allowing for individualized prediction of outcomes in immunotherapy patients. More...
10 Feb 2022
Image: Heart rate variability changes with levels of inflammatory serum markers. Left: normal levels of IL-12 and ICAM-1 associated with normal heart rate variability. Right: increased levels of IL-12 and ICAM-1 resulting in decreased heart rate variability. IL-12 is known to associate with arterial stiffness in healthy (Photo courtesy of BMC)

Elevated Interleukin-12/23p40 Indicates Dysfunctional Heart Rate Variability in T2D

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in type 2 diabetes (T2D), accounting for approximately 50% of all deaths. Cardiovascular functions, including heart rate, heart contractility, and blood pressure, are regulated by autonomic sympathovagal balance. More...
08 Feb 2022
Image: Schematic diagram of image-enabled cell sorting, developed at BD Biosciences and  tested by European Molecular Biology Laboratory (Photo courtesy of BD Bioscience)

High-Speed Fluorescence Image-Enabled Cell Sorting Tested

Cell sorting through flow cytometry is a technique that enables scientists to identify and sort individual cells based on specific characteristics of each cell in order to study them in more detail, evaluate how each cell may react to a new drug or perform other single cell studies. More...
03 Feb 2022
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.