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Immunology

Image: The HYDRASYS 2 Electrophoresis Automated System (Photo courtesy of Sebia).

Paraproteins Identification Methods Compared for Monoclonal Gammopathies

Monoclonal gammopathy, also known as paraproteinemia, is the presence of excessive amounts of myeloma protein or monoclonal gamma globulin in the blood. It is usually due to an underlying immunoproliferative disorder or hematologic neoplasms, especially multiple myeloma. More...
18 Mar 2021
Image: The Mindray CL-2000i Chemiluminescence Immunoassay System (Photo courtesy of Mindray Bio‐Medical Electronics).

Chemiluminescence Anti‐Müllerian Hormone Assay Performance Characterized

Müllerian hormone (AMH), a dimeric glycoprotein hormone, is a member of the transforming growth factor‐β superfamily that plays a predominant role in male and female sexual differentiation. More...
18 Mar 2021
Image: The Elecsys high-sensitivity cardiac troponin T (hs-cTnT) assay: as immunological method for the in vitro quantification of cardiac troponin T in human serum and plasma (Photo courtesy of Roche Diagnostics).

Cardiac Troponins Assessed for Acute Heart Failure

Heart failure (HF) is a clinical syndrome characterized by dyspnea, peripheral edema and fatigue. Diagnosing HF can be difficult due to overlapping symptoms with other conditions, and the phenotype of HF varies due to a broad spectrum of underlying pathophysiology. More...
17 Mar 2021
Image: An enzyme-linked immunosorbent assay (ELISA) measured serum 14–3-3η levels and evaluated in juvenile idiopathic arthritis (Photo courtesy of Quest Diagnostics).

Biomarker Protein Investigated in Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatologic disease that may persist into adulthood and impact quality of life. The diagnosis is mainly based on clinical assessment rather than relying on laboratory testing. More...
09 Mar 2021
Image: Schematic diagram of Type 1 Diabetes (TID). Immune Response to Insulin Could Identify and Help Treat Those at Risk for TID (Photo courtesy of Harvard Medical school).

Immune Response to Insulin Identifies Risk of Juvenile-Diabetes

Type 1 diabetes (T1D), also known as juvenile diabetes, is a form of diabetes in which very little or no insulin is produced by the islets of Langerhans (containing β-cells) in the pancreas. Insulin is a hormone required for the body to use blood sugar. More...
08 Mar 2021
Image: The Atellica CH 930 Immunoassay & Clinical Chemistry Analyzer (Photo courtesy of Siemens Healthcare).

Fibrinogen to Albumin Ratio Reflects ANCA‐Associated Vasculitis Activity

Microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA) belong to a group of anti-neutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV). More...
04 Mar 2021
Image: Schematic diagram of Rh alloimmunization in chronically transfused patients with thalassemia receiving RhD, C, E, and K matched transfusions (Photo courtesy of The Children’s Hospital of Philadelphia).

Rh Alloimmunization Explored in Chronically Transfused Thalassemia Patients

Chronic life-long transfusions are often required for patients with severe thalassemia to provide normal red blood cells and to suppress the patients’ own ineffective erythropoiesis. Cumulative exposure increases the risk for red cell alloimmunization and subsequent delayed hemolytic transfusion reactions (DHTRs). More...
01 Mar 2021
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.