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Hematology

Image: Laser scanning confocal microscopy of clots constructed from adult fibrinogen (A), neonatal fibrinogen (B), or a mixture of the two (C). Scale bar= 20 μm (Photo courtesy of North Carolina State University).

Fibrin Network Changes in Neonates After Cardiopulmonary Bypass

Quantitative and qualitative differences in the hemostatic systems exist between neonates and adults, including the presence of “fetal” fibrinogen, a qualitatively dysfunctional form of fibrinogen that exists until one year of age.  More...
22 Mar 2016
Image: Histopathology comparing normal bowel at the left, to a bowel involved by necrotizing enterocolitis (NEC) at the right showing hemorrhagic necrosis, beginning in the mucosa and extending to involve the muscular wall, with the potential for perforation (Photo courtesy of the University of Utah School of Medicine).

Severe Anemia Associated with Increased Risk of Necrotizing Enterocolitis

Necrotizing enterocolitis an acute, life-threatening, inflammatory disease occurring in the intestines of premature infants, is a leading cause of mortality among preterm infants with case-fatality rates of 20% to 30% yet the origin and development of NEC remains unclear.  More...
16 Mar 2016
Image: The “SCD biochip” microfluidic system for probing red blood cell (RBC) dynamic deformability and adhesion from whole sickle cell disease (SCD) patient blood samples (Photo courtesy of Case Western Reserve University).

Novel Device Measures Stiffness and Stickiness in Erythrocytes

In sickle cell disease, hemoglobin molecules polymerize intracellularly and lead to a cascade of events resulting in decreased deformability and increased adhesion of red blood cells. Decreased deformability and increased adhesion of sickle RBCs lead to blood vessel occlusion, known as vaso-occlusion, in SCD patients.   More...
13 Mar 2016
Image: Photomicrograph of blood smear devoid of platelets from a patient with thrombocytopenia (Photo courtesy of the Icahn School of Medicine at Mount Sinai).

Higher Histone Levels Associated with Thrombocytopenia

Thrombocytopenia is observed in approximately 30% to 40% of patients in the intensive care unit concomitant with poor outcomes and an association with histones has been examined.   More...
09 Mar 2016
Image: The Projet 1200 3D printer was able to easily produce and refine the device from environmentally friendly materials to make low cost, point-of-care devices that quickly detect anemia from a drop of blood (Photo courtesy of Kansas State University).

3D Printed Diagnostic Device Rapidly Detects Anemia

A new biomedical device has been developed using 3D printers to create a low cost, point-of-care device that can quickly detect anemia, a condition in which the blood does not have enough healthy red blood cells to transport oxygen to the body's organs.   More...
07 Mar 2016
Image: Sysmex C-1500 automatic coagulation analyzer (Photo courtesy of Siemens Healthcare).

D-Dimer Efficacy Evaluated for Disseminated Intravascular Coagulation Diagnosis

Disseminated intravascular coagulation refers to an acquired syndrome characterized by procoagulant substances entering the general circulation and leading to a systemic thrombotic process, which may be derived from or causing microvascular system damage.  More...
17 Feb 2016
Image: Blood transfusion components that include red blood cells, plasma and other clotting products (Photo courtesy of the Australian Red Cross Service).

Major Trauma Emergency Blood Transfusions Need Consistency

Globally, bleeding following injury is estimated to be responsible for over two million deaths per year and current treatment strategies focus on the rapid delivery of red blood cells, plasma and other clotting products.  More...
16 Feb 2016
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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