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Hematology

Image: Electron micrograph of Bartonella henelae, Gram-negative bacteria that causes cat scratch fever (Photo courtesy of the Prokaryotes).

Emerging Blood-Borne Bacteria Found in Blood Donors

Bartonella species cause chronic and intermittent intra-erythrocytic bacteremia and infect endothelial cells of both incidental and natural reservoir hosts. The establishment of chronic, stealth infection is achieved by evasion of innate immune responses.  More...
04 Apr 2016
Image: Schematics of the combination of Amotosalen and UVA illumination for eliminating pathogens from donor blood for transfusions (Magdy El Ekiaby, MD).

Zika Virus Inactivated in Plasma for Transfusion

The potential for Zika virus transmission through blood transfusion has been demonstrated during the French Polynesian outbreak as 2.8% of blood donors, who were asymptomatic at the time of donation, were found positive for acute ZIKV infection using specific reverse transcription–polymerase chain reaction.   More...
03 Apr 2016
Image: The FACSAria III cell sorter instrument (Photo courtesy of BD Biosciences).

Immune Cells Adapt Inefficiently in Patients with Uncontrolled HIV

Antibodies derived from a type of immune cell found in unusually high numbers in human immunodeficiency virus-infected individuals with chronically uncontrolled virus levels are less effective at neutralizing HIV than antibodies derived from a different type of immune cell more common in people without HIV.  More...
28 Mar 2016
Image: The Bio-Flash Rapid-Response Chemiluminescent Analyzer (Photo courtesy of Inova Diagnostics).

Immunoassay Systems Evaluated for Detection of Antiphospholipid Antibodies

Antiphospholipid syndrome or antiphospholipid antibody syndrome, or also Hughes syndrome, is an autoimmune, hypercoagulable state caused by antiphospholipid antibodies.  More...
28 Mar 2016
Image: Blood smear showing a segmented neutrophil and a mature lymphocyte with a single large nucleus (Photo courtesy of the University of Utah Medical School).

Early Stage Breast Cancer Recurrence Linked to High Leukocyte Ratio

A high ratio of two types of immune system cell is linked to an increased risk of disease recurrence after a diagnosis of early stage breast cancer and the findings might guide future treatment and monitoring strategies, if prospective studies confirm the link.  More...
23 Mar 2016
Image: The Videssa Breast diagnostic test provides accurate early detection and typing of breast cancers by combining anatomical evidence from imaging with evidence from its proteomics test for proteins released into the blood system by cancer tumors (Image courtesy of Provista Diagnostics).

Age Should Be Considered in Developing Diagnostic Assays

In a new study on breast cancer, blood test results have demonstrated age-related differences in Tumor-Associated Antibodies, showing for the first time age-related differences that should be taken into consideration when developing diagnostic tests.  More...
23 Mar 2016
Image: Laser scanning confocal microscopy of clots constructed from adult fibrinogen (A), neonatal fibrinogen (B), or a mixture of the two (C). Scale bar= 20 μm (Photo courtesy of North Carolina State University).

Fibrin Network Changes in Neonates After Cardiopulmonary Bypass

Quantitative and qualitative differences in the hemostatic systems exist between neonates and adults, including the presence of “fetal” fibrinogen, a qualitatively dysfunctional form of fibrinogen that exists until one year of age.  More...
22 Mar 2016
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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