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Molecular Diagnostics

Image: Photomicrograph of a blood film from a patient with acute lymphoblastic leukemia (Photo courtesy of St Jude Children’s Research Hospital)

Certain Childhood ALL Subtypes Linked to Genetic Ancestry

Acute lymphoblastic leukemia (ALL) is a type of cancer that affects white blood cells. It progresses quickly and aggressively and requires immediate treatment. Both adults and children can be affected. Although it is rare, ALL is the most common type of leukemia that affects children. More...
10 Feb 2022
Image: The Quantus Fluorometer is a compact, dual-channel fluorometer designed to provide highly sensitive fluorescent detection when quantifying nucleic acids (Photo courtesy of Promega)

Intestinal Microbiota Determines the Risk of MDRO Acquisition

Colonization and infection by multidrug-resistant organisms (MDRO) remains a public health problem. This is particularly important in intensive care units (ICUs) where the risk of MDRO acquisition/colonization results from the selective pressure associated with prolonged broad-spectrum antibiotic treatment. More...
10 Feb 2022
Image: The Simoa HD-1 Analyzer was used for measuring plasma biomarkers of dementia (Photo courtesy of Quanterix)

Blood Biomarkers May Distinguish Dementia Disorders

Clinical diagnostics and clinical trials will benefit from scalable non-invasive biomarkers moving beyond positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) analysis to blood based assays. More...
09 Feb 2022
Image: Ball-and-stick model of the kynurenine molecule, a metabolite of the amino acid tryptophan. Evidence suggests that increased kynurenine production may precipitate depressive symptoms (Photo courtesy of Wikimedia Commons)

Biomarker Panel Predicts Depressive Symptoms in Pregnant and Postprartum Women

A recent paper described the establishment of a set of biological markers found in the blood that can predict if pregnant or postpartum women will experience significant depressive symptoms. More...
09 Feb 2022
Image: The Agilent DNA Microarray Scanner (Photo courtesy of Agilent Technologies)

Novel Urinary miRNA Biomarker for Early Detection of Colorectal Cancer

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Pathological diagnosis using biopsy samples acquired during a colonoscopy (CS) is the gold standard for CRC diagnosis. More...
07 Feb 2022
Image: Histopathology of adenocarcinoma of the prostate on needle biopsy consisting of small glands with amphophilic cytoplasm (Photo courtesy of Professor Jonathan I. Epstein, MD)

Genetic Clues Link Lipoprotein A to Prostate Cancer Risk

Some factors associated with higher risk of prostate cancer (PCa) cannot be modified, such as older age and being of African descent. Meanwhile, other risk factors for the aggressive form of the disease, such as smoking and obesity, can potentially be modified. More...
07 Feb 2022
Image: Gene fusions play a key role in the formation and spread of nearly 20% of all human cancers. This schematic shows the ways a fusion gene can occur at a chromosomal level (Photo courtesy of Wikimedia Commons)

RNA Sequencing Improves Gene Fusion Detection for Childhood Cancer Diagnostics

Analysis of whole tumor RNA in children with cancer significantly increases the detection of gene fusions, which can provide information concerning the exact cancer type, the aggressiveness of the tumor, and the possible benefit of targeted drugs. More...
07 Feb 2022
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DH-800 Series
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.