Molecular Diagnostics

Analytic Validation and Clinical Utilization of Comprehensive Genomic Profiling Test

Cancer has a high clinical burden and oncology therapies are expensive. It is estimated that 1,898,160 new cancer cases will be diagnosed and over 608,570 deaths are projected to occur in the USA in 2021. The prevalence of cancer is expected to rise over time, providing an expanding unmet need for genomic tests to help physicians treat patients in a more precise manner. More...
02 Jun 2021

Image: Schematics of the workflow for the Geneseeq Prime 425-gene panel (Photo courtesy of Geneseeq Technology)

Colorectal Cancer Relapse Predicted by ctDNA Clearance

Colorectal cancer (CRC) is the third most common cancer around the world with more than 1.9 million new cases diagnosed annually. CRC is also the second leading cause of cancer-related deaths with a 5-year mortality rate of about 40%. More...
01 Jun 2021

Urinary Interleukin-8 May Be the Ultimate Bladder Cancer Biomarker

A recently published study established that the urinary protein interleukin-8 (IL-8) not only distinguished bladder cancer from controls, it also discriminated high grade from low grade disease, and the successive clinical stages of bladder cancer. More...
01 Jun 2021

Image: Neurons were grown in tissue culture and stained with antibody to microtubule associated protein 2 (MAP2) protein in green and MAP tau in red. MAP2 is found only in dendrites and perikarya, while tau is found in these sites and in axons as well. DNA is shown in blue (Photo courtesy of EnCor Biotechnology Inc. via Wikimedia Commons)

Plasma-Based Algorithm Accurately Predicts Likelihood of Developing Alzheimer’s Disease

A team of Swedish researchers has created an algorithm for use by physicians lacking access to advanced diagnostic instruments, which accurately predicts future risk of developing Alzheimer’s disease (AD). More...
31 May 2021

Image: Schematic of workflow for urinary DNA jagged end analysis. Urinary DNA was subjected to an end-repair process; JI-U = jagged index–unmethylated (Photo courtesy of The Chinese University of Hong Kong)

Jagged Ends of Urinary Cell-Free DNA Assessed in Bladder Cancer Detection

Bladder cancer is where a growth of abnormal tissue, known as a tumor, develops in the bladder lining. In some cases, the tumor spreads into the bladder muscle. The most common symptom of bladder cancer is blood in the urine, which is usually painless. More...
27 May 2021

$Image: Histopathology of Alzheimer\'s disease in the CA3 area of the hippocampus: Amyloid plaque (top right), neurofibrillary tangles (bottom left) and granulovacuolar degeneration (bottom center). All three images were taken at the same high magnification (Photo courtesy of Wikimedia Commons)$