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Molecular Diagnostics

Image: Structure of the major histocompatibility complex, class II, DQ beta 1 (HLADQB1) gene (Photo courtesy of Protein Data Bank).

Causal Role Found for Common Genetic Variant in Narcolepsy

An extraordinary association has been found between a specific gene variant related to the human leukocyte antigen immune system and narcolepsy.   More...
14 Jan 2014

Collaboration to Examine the Utility of KRAS Mutations in Urine

Trovagene and US Oncology Research will examine the utility of quantitative urine-based KRAS mutation detection and monitoring in pancreatic cancer patients.  More...
13 Jan 2014
Image: A positive test with the Break Apart fluorescence in situ hybridization (FISH) Probe kit for anaplastic lymphoma kinase gene (ALK) (Photo courtesy of Abbott Molecular).

Known Lung Cancer Oncogenes Drive Colorectal Cancer

Activation of tyrosine kinase proto-oncogenes, through gene fusions, has been found in lung adenocarcinomas and they are highly sensitive to selective kinase inhibitors.  More...
09 Jan 2014
Image: Electron micrograph showing an increased number of mitochondria in the subsarcolemmal space from a patient with mitochondrial myopathy (Photo courtesy of the Virginia Commonwealth University).

Myopathy Diagnosis Improved by New Gene Mutation

A new gene mutation has been discovered which will help doctors give a more accurate diagnosis of a particular type of brain and muscle disease in children.  More...
08 Jan 2014
Image: PCR products of methylenetetrahydrofolate reductase C677T DNA samples extracted with magnetic nanoparticles using saliva samples (lanes 1-5) and with traditional methods using blood samples (lanes 7-11) (Photo courtesy of Neural Regeneration Research).

Analysis of Saliva DNA Suggested for Screening Stroke-Linked Mutation

Results of real-time PCR analysis of saliva samples from stroke patients and normal controls obtained using a noninvasive magnetic nanoparticle-based technique were consistent with those from conventionally treated blood samples, which had been taken at the same time.  More...
06 Jan 2014
Image: Biacore Sensor Chip for ligand capture (Photo courtesy of GE Healthcare).

Newly Identified Immune Receptor Activates B Cells in Autoimmunity

A newly identified immune protein influences each person's response to vaccines and risk for autoimmune diseases like systemic lupus erythematosus and multiple sclerosis.   More...
01 Jan 2014
Image: An 8-month-old infant with an extensive cleft palate associated with the genetic condition Bamforth- Lazarus syndrome (Photo courtesy of Maynika V Rastogi and Stephen H LaFranchi).

Dominant Gene Mutations Causes Van der Woude Syndrome

A new gene has been identified that is related to the Van der Woude syndrome, the most common syndrome with cleft lip and palate.   More...
01 Jan 2014
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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