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Molecular Diagnostics

Image: The RainDrop droplet polymerase chain reaction system (Photo courtesy of RainDance Technologies).

DNA in Blood Tracks Cancer Development and Response

Circulating tumor DNA analysis can be used to track tumor burden and analyze cancer genomes noninvasively, but the extent to which it represents metastatic heterogeneity is unknown.  More...
23 Nov 2015
Image: The Qubit Fluorometer accurately detects and quantifies very low concentrations of DNA, RNA, and protein (Photo courtesy of Great Lakes Genomics Center).

Blood Test Increases Accuracy in Prenatal Testing

A simple, accurate and low risk blood test can detect fetal blood group, sex, and genetic conditions in unborn babies and the DNA test is inexpensive and is noninvasive, as opposed to the traditional amniocentesis test that involves a needle and carries a minor risk of miscarriage.   More...
22 Nov 2015
Image: Apolipoprotein E ε4 is associated with disease-specific effects on brain atrophy in Alzheimer\'s disease and behavioral variant frontotemporal dementia (bvFTD) (Photo courtesy of Dr. Federica Agosta).

Genetic Risk Marker Found for Late-Life Depression

The epsilon 4 allele of the apolipoprotein gene has been associated with atherosclerosis as well as cardiovascular and cerebrovascular disease but it is less clear whether there is also an association with geriatric depression.  More...
22 Nov 2015
Image: Droplet digital polymerase chain reaction system (Photo courtesy of Bio-Rad).

Blood Samples Analysis Monitors Colorectal Cancer Chemotherapy Response

Circulating cell-free DNA may be collected from plasma of colorectal cancer patients and represents a less invasive, less costly approach to tracking biomarkers of interest longitudinally and at progression.  More...
18 Nov 2015
Image: The Diagnostics-in-a-Suitcase used to screen for Ebolavirus disease (Photo courtesy of Institut Pasteur, Dakar).

Rapid Ebola Virus Detection Assay Evaluated

Ebolavirus infection is mainly diagnosed by various in-house and commercial real-time reverse transcriptase polymerase chain reaction assays used in up to 38 laboratories implemented at or close to Ebola treatment centers in West Africa.  More...
17 Nov 2015
Image: Schematic diagram of circulating tumor DNA (ctDNA), a small piece of DNA released from dying cancer cells into the blood (Photo courtesy of Jonathan Bailey).

Cancer DNA in Blood Helps Personalize Liver Cancer Treatment

Liver cancer tumor specimens are difficult and sometimes dangerous to obtain, and noninvasive methods are required to assess cancer progression and characterize underlying genomic features.  More...
15 Nov 2015
Image: Mucocutaneous papilloma manifestations around the nose of an autosomal dominant condition known as Cowden syndrome (Photo courtesy of University of Sao Paulo).

Predisposing Gene Associated With Cowden Syndrome

A new gene has been discovered that is associated with Cowden syndrome, an inherited condition that carries high risks of thyroid, breast, and other cancers, and a subset of non-inherited thyroid cancers.  More...
15 Nov 2015
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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