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Molecular Diagnostics

Image: Photomicrograph of ductal breast carcinoma in situ shows several ducts to be filled with carcinoma cells (Photo courtesy of Breastpath).

Breast Cancer Test Optimizes Treatment Recommendations

The first prospective outcomes data from a large Women's Healthcare Study Group for contemporary adjuvant breast cancer trials has identified patients who would be more likely to benefit from chemotherapy treatment.   More...
06 Jan 2015

Genome Analysis Study to Aid Diagnosis of Rare Developmental Disorders

First results from a study that will eventually incorporate complete genome analysis of 12,000 families in the United Kingdom and the Republic of Ireland have revealed 12 novel genes associated with rare and difficult to diagnose developmental disorders.  More...
06 Jan 2015
Image: Micrograph of an intrahepatic cholangiocarcinoma (right of image) adjacent to benign hepatocytes (left of image) (Photo courtesy of Wikimedia Commons).

Canadian Researchers Identify Mutations Linked to Rare Form of Liver Cancer

Canadian cancer researchers working with patients in China have identified mutations linked to the development of intrahepatic cholangiocarcinoma, a rare, highly fatal form of liver cancer that disproportionately affects individuals of Asian origin.  More...
05 Jan 2015
Image: Scanning electron microscope (SEM) photograph of fibroblasts in gel cultured on microfluidic chip (Photo courtesy of the University of Michigan).

Cell Culture Technique Leads to Tailor-Made Cancer Treatments

A novel in situ capture and culture methodology has been developed for ex vivo expansion of circulating tumor cells using a three dimensional co-culture model, simulating a tumor microenvironment to support tumor development.  More...
04 Jan 2015

Whole Genome Sequencing Demonstrates Potential for Diagnosis and Discovery in the Cancer Genetics Clinic

Cancer researchers have determined to what extent diagnostic whole genome sequencing can contribute to the prediction of the risk for development of the disease.  More...
04 Jan 2015
Image: A histology slide stained with hematoxylin and eosin (H&E) and the corresponding three-dimensional cancer density map, which facilitate the measurement of spatial proximity to cancer for every single lymphocyte in the image (Photo courtesy of The Institute of Cancer Research).

Gene Expression Correlates with Lymphocyte Infiltration in Breast Cancer

Lymphocytic infiltration is associated with a favorable prognosis and predicts response to chemotherapy in many cancer types, including the aggressive triple-negative breast cancer.  More...
30 Dec 2014
Image: Micrograph of a pleural fluid cytopathology specimen showing mesothelioma (Photo courtesy of Wikimedia Commons).

Mutations in Rare Asbestos-Caused Cancer Identified by Targeted Next-Generation Sequencing

Targeted next-generation sequencing, an advanced genomic analysis tool, was used to identify genes linked to the development of the rare cancer malignant pleural mesothelioma.  More...
29 Dec 2014
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