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Molecular Diagnostics

Image: A schematic diagram of a new method that rapidly analyzes the RNA (green strands) of HIV for mutations (red dot) that convey drug resistance. The system does not require transcription of RNA to DNA, as current technologies do, and works within one solution (purple droplet) (Photo courtesy of Dr. Lei Zhang, Brown University).

One-Tube RNA Ligation and Amplification Method for Rapid Detection of Drug Resistant HIV

By not requiring transcription of RNA to DNA, a novel one-tube method allows the rapid detection of drug resistant strains of HIV.  More...
28 Oct 2015
Image: The 3M Integrated Cycler with assay kits (Photo courtesy of Focus Diagnostics).

Simplexa Direct Test Includes 53 New Virus Strains

The Simplexa test kit for select virus strains can detect a total of 92 influenza and respiratory syncytial virus virus strains, more than any other officially cleared molecular test kit.  More...
20 Oct 2015
Image: Ciliary ultrastructure on the right from a patient with primary ciliary dyskinesia (PCD) showing the absence of outer and inner dynein arms and on the left normal cilium from a healthy individual in which both inner and outer dynein arms can clearly identified (Photo courtesy of Dr. J. Carson, PhD).

Test Menu Expanded to Include Hundreds of New Genes

A genetic information company has announced that it has more than doubled the size of its genetic testing platform to include more than 600 genes and will release the new content between now and the end of 2015.  More...
20 Oct 2015
Image: In Roche’s Cervical Cancer Screening Portfolio, the “CINtec p16 Histology” immunohistochemistry assay detects p16-INK4a in cervical biopsy preparations. The figure illustrates that in cells with transforming HPV infections, HPV viral oncoprotein E7 impairs the function of pRB, disrupting its ability to bind to E2F. This leads to deregulated cell proliferation, genetic instability, and p16 over-expression detectible by immunohistochemistry staining (Image courtesy of Ventana, of Roche).

Screening Portfolio Protects Patients from Cervical Cancer and Overtreatment

A new portfolio of clinically validated genetic and pathology tests for human papillomavirus cervical cancer screening and diagnosis helps identify women at high risk of developing this highly preventable disease, which is nevertheless still classified as the 4th most frequent cancer in women—530,000 new cases annually, of which about half the patients die.  More...
20 Oct 2015
Image: A new test can detect virtually any virus that infects people and animals, including the Ebolavirus depicted in this enhanced electron micrograph (Photo courtesy of the [US] National Institute of Allergy and Infectious Diseases).

New Target Sequence Capture Panel Eases Detection of Viruses in Patient Samples

A recently developed targeted sequence capture panel, ViroCap, which was designed to enrich nucleic acid from DNA and RNA viruses that infect vertebrate hosts, allowed the rapid detection of unknown viruses in patient samples.   More...
14 Oct 2015
Image: The Oncotype DX specimen and collection kit for Breast Cancer Recurrence Score Assay (Photo courtesy of Genomic Health).

Gene Test Validated for Breast Cancer Therapy

A genetic test has been clinically validated in predicting which patients with early-stage breast cancer are unlikely to benefit from chemotherapy.  More...
12 Oct 2015
Image: Photomicrograph of a band-form trophozoite of P. malariae in a thin blood smear (Photo courtesy of the CDC – [US] Centers of Disease Control and Prevention).

Humans Affected by Same Malaria Parasite as Monkeys

The quartan malaria parasite Plasmodium malariae is the widest spread and best adapted human malaria parasite while the simian P. brasilianum causes quartan fever in New World monkeys and resembles P. malariae morphologically.  More...
07 Oct 2015
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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