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Molecular Diagnostics

Image: In Roche’s Cervical Cancer Screening Portfolio, the “CINtec p16 Histology” immunohistochemistry assay detects p16-INK4a in cervical biopsy preparations. The figure illustrates that in cells with transforming HPV infections, HPV viral oncoprotein E7 impairs the function of pRB, disrupting its ability to bind to E2F. This leads to deregulated cell proliferation, genetic instability, and p16 over-expression detectible by immunohistochemistry staining (Image courtesy of Ventana, of Roche).

Screening Portfolio Protects Patients from Cervical Cancer and Overtreatment

A new portfolio of clinically validated genetic and pathology tests for human papillomavirus cervical cancer screening and diagnosis helps identify women at high risk of developing this highly preventable disease, which is nevertheless still classified as the 4th most frequent cancer in women—530,000 new cases annually, of which about half the patients die.  More...
20 Oct 2015
Image: A new test can detect virtually any virus that infects people and animals, including the Ebolavirus depicted in this enhanced electron micrograph (Photo courtesy of the [US] National Institute of Allergy and Infectious Diseases).

New Target Sequence Capture Panel Eases Detection of Viruses in Patient Samples

A recently developed targeted sequence capture panel, ViroCap, which was designed to enrich nucleic acid from DNA and RNA viruses that infect vertebrate hosts, allowed the rapid detection of unknown viruses in patient samples.   More...
14 Oct 2015
Image: The Oncotype DX specimen and collection kit for Breast Cancer Recurrence Score Assay (Photo courtesy of Genomic Health).

Gene Test Validated for Breast Cancer Therapy

A genetic test has been clinically validated in predicting which patients with early-stage breast cancer are unlikely to benefit from chemotherapy.  More...
12 Oct 2015
Image: Photomicrograph of a band-form trophozoite of P. malariae in a thin blood smear (Photo courtesy of the CDC – [US] Centers of Disease Control and Prevention).

Humans Affected by Same Malaria Parasite as Monkeys

The quartan malaria parasite Plasmodium malariae is the widest spread and best adapted human malaria parasite while the simian P. brasilianum causes quartan fever in New World monkeys and resembles P. malariae morphologically.  More...
07 Oct 2015
Image: The replacement of the amino acid arginine by a cysteine at position 117 in POT1p.R117C produces conformational changes in the protein that are incompatible with an efficient connection to the telomere, inducing an aberrant telomere elongation and fragile telomeres in the mutated cells (Photo courtesy of CNIO).

Mutated Gene Found in Families with Multiple Tumors

Cardiac angiosarcoma is a rare but malignant disease and in the case of hereditary CAS, the median survival expectancy is only four months because the disease is diagnosed at an advanced stage.   More...
05 Oct 2015
Image: NucliSENS- easyMAG automated platform specifically optimized for total nucleic acid extraction (Photo courtesy of bioMérieux).

Virome Capture Sequencing Enables Sensitive Viral Diagnosis

Insensitivity and technical complexity have impeded the implementation of high-throughput nucleic acid sequencing in differential diagnosis of viral infections in clinical laboratories.   More...
05 Oct 2015
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DNA Alterations Identified Occur Earliest in Lung Cancer Development

Lungs resected for adenocarcinomas often harbor minute discrete foci of cytologically atypical pneumocyte proliferations designated as atypical adenomatous hyperplasia, which may represent an initial step in the progression to adenocarcinoma in situ.  More...
30 Sep 2015
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.