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Molecular Diagnostics

Image: The NextSeq 500 Series desktop sequencing system (Photo courtesy of Illumina).

Improved “Liquid Biopsy” Technique Enhances Tumor DNA Detection

An improved method has been devised to significantly increase the sensitivity of a technique to identify and sequence DNA from cancer cells circulating in a person's blood. The hope is that such "liquid biopsies" of easily obtained blood samples could one day replace the need to surgically obtain tumor tissue for examination.  More...
10 Apr 2016
Image: Micrograph of pancreatic ductal adenocarcinoma (the most common type of pancreatic cancer) (Photo courtesy of Wikimedia Commons).

Establishment of Biomarker Panel May Lead to Rapid Tests for Early Diagnosis of Pancreatic Cancer

A panel comprising five genetic biomarkers was shown to accurately differentiate among tissues from pancreatic tumors and those taken from various non-malignant sources.  More...
10 Apr 2016
Image: Sarocladium kiliense after 10 days’ growth on Sabouraud-Dextrose Agar at 30 °C (Photo courtesy of Thunderhouse4-yuri).

Genomic Sequencing Identifies Deadly Bloodstream Infection

The differentiation between fungal infections originating from a single contaminated point source and those independently acquired from the environment is often difficult.  More...
06 Apr 2016
Image: Histopathology of a skin section from a patient with superficial spreading malignant melanoma (Photo courtesy of Profs. Leszek Wozniak and Krzysztof W. Zielinski).

Noncoding RNA Gene Linked to Malignant Melanoma

While a large share of the human genome has long been considered “junk DNA” because it does not contribute to protein coding, recent insights indicate that it does produce many noncoding ribonucleic acids that play important roles in essential biological processes and diseases.   More...
05 Apr 2016
Image: Histopathology of colon adenocarcinoma composed of chaotic glandular structures that are lined by one or more rows of cancer cells with or without mucus production (Photo courtesy of the Johns Hopkins University).

Novel Blood Test Detects Colorectal Cancer Recurrence Earlier

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide, accounting for more than 600,000 deaths each year. When diagnosed early, before cancer has spread, the relative five-year survival rate for CRC is 90%, but only about 4 out of 10 CRC cases are detected early.  More...
05 Apr 2016
Image: Schematics of the three biomarker myChoice homologous recombination deficiency (HRD) assay (Photo courtesy of Myriad Genetics).

Hereditary Cancer Test Identifies Deleterious Mutations in Endometrial Cancer

Two recent studies have shown that a Hereditary Cancer test can identify deleterious mutations in patients with endometrial cancer and additionally, showed the superior ability of the combined three biomarker test to predict survival in patients with platinum treated ovarian cancer.  More...
05 Apr 2016
Image: Immunochemistry of receptors for estrogen (ER), strong and diffuse nuclear staining in a tissue sample from a breast cancer patient (Photo courtesy of Steven Halls, MD).

Multigene Test Identifies Early Breast Cancer

The 21-gene Recurrence Score assay, nodal status, grade, and immunohistochemical markers are recommended for chemotherapy decision making in hormone receptor positive/ human epidermal growth factor receptor negative early breast cancer.  More...
30 Mar 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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