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Molecular Diagnostics

Image: Molecular model of the prostate cancer drug abiraterone (Photo courtesy of Wikimedia Commons).

Analysis of Circulating DNA Predicts Prostate Cancer's Development of Drug Resistance

Analysis of prostate cancer DNA circulating in the bloodstream identifies a mutation that indicates whether the tumor will become resistant to the drug-of-choice abiraterone, and enables the physician to choose an alternative treatment.  More...
15 Nov 2015
Image: The QX200 AutoDG Droplet Digital polymerase chain reaction (ddPCR) dystem (Photo courtesy of Bio-Rad).

Molecular Technology Identifies Viral RNA Mutations in Clinical Samples

Droplet Digital polymerase chain reaction uses emulsion chemistry to partition nucleic acid samples into approximately 20,000 oil-encapsulated nanodroplets to produce data that surpasses the precision of other molecular methods with equivalent or much higher sensitivity.  More...
09 Nov 2015
Image: Histopathology of a testicular germ cell tumor consisting of teratoma, embryonal carcinoma yolk sac tumor and syncytiotrophoblasts (Photo courtesy of Lee Moffitt Cancer Center).

Four Susceptibility Loci Identified for Testicular Germ Cell Tumor

Testicular germ cell tumor is the most common cancer in men aged 15 to 45 years, with over 18,000 new cases diagnosed annually in Europe and the incidence of TGCT has approximately doubled over the last four decades in Western Europe, which implicates environmental or lifestyle factors as risk determinants.  More...
08 Nov 2015
Image: Colorized transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by an Ebolavirus virion with supplemented spermatozoa (Photo courtesy of Frederick A. Murphy/CDC, and Graphic by Mark Murrman).

Ebolavirus Found in Semen Months After Symptom Onset

The main mode of transmission is direct contact with the blood or body fluids of a person with Ebolavirus disease or from the body of a person who died from the disease; however, Ebolavirus can persist in the body fluids of survivors during convalescence, which may result in transmission of the virus.   More...
04 Nov 2015
Image: MinION USB-attachable miniature DNA sequencing device (Photo courtesy of Oxford Nanopore).

Miniature DNA Sequencing Device Independently Evaluated

The performance of a hand held miniature DNA sequencing device has been evaluated by an open, international consortium, and the resulting recommendations and protocols are available.   More...
04 Nov 2015
Image: New study shows that blood testing by targeted-NGS of extracted cfDNA could help match cancer patients with the most appropriate targeted therapy and to simply and quickly monitor response to treatment (Photo courtesy of Cancer Research UK).

Blood Test Could Match and Monitor Cancer Patients and Treatment

Researchers have found that new generation sequencing of circulating cell-free DNA in blood plasma could help successfully pair cancer patients with the most suitable therapy and track tumor progression to assess treatment effectiveness.  More...
01 Nov 2015
Image: The HiSeq 2500 ultra-high-throughput sequencing system (Photo courtesy of Illumina).

Novel Diagnostic Technology Rapidly Identifies Cancer Source

A substantial proportion of cancer cases present with a metastatic tumor and require further testing to determine the primary site; many of these are never fully diagnosed and remain cancer of unknown primary origin.  More...
28 Oct 2015
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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