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Molecular Diagnostics

Image: An invasive adenocarcinoma (the most common type of colorectal cancer). The cancerous cells are seen in the center and at the bottom right of the image (blue). Near normal colon-lining cells are seen at the top right of the image (Photo courtesy of Wikimedia Commons).

Detection of Circulating Tumor DNA Predicts Colon Cancer Recurrence

A team of American and Australian cancer researchers has demonstrated that circulating fragments of tumor DNA (ctDNA) could serve as a biomarker for identifying patients with high risk of recurrence of colon cancer. More...
18 Jul 2016
Image: The E220 focused-ultrasonicator for DNA fragmentation (Photo courtesy of Covaris).

Genetic Causes of Bowel Cancer Clarified

Colorectal cancer (CRC) displays a complex pattern of inheritance and it is postulated that much of the missing heritability of CRC is enshrined in high-impact rare alleles, which are mechanistically and clinically important. More...
14 Jul 2016
Image: The Thermo-Finnigan LTQ mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Plasma Mannose Levels May Indicate Diabetes Risk

Obesity is associated with an increased risk for a wide range of morbidities, including insulin resistance (IR), type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease (CVD). More...
14 Jul 2016
Image: A histology of the small intestinal mucosa; the normal is on the left. The mucosa involved by celiac disease (sprue) at the right has blunting and flattening of villi (Photo courtesy of the CDC).

Celiac Disease Triggered by Intestinal Viruses

Digestive problems, severe inflammation of the small intestine and nutritional deficiencies leading to anemia and osteoporosis force patients of the autoimmune condition celiac disease to follow a strict gluten-free diet for life. More...
14 Jul 2016
Image: The LightCycler 480 real-time PCR system (Photo courtesy of Roche).

Circulating MicroRNAs Predict Future Fatal Myocardial Infarction

Coronary heart disease is the most common cause of death, and the number of individuals at risk is increasing and to better manage this pandemic, improved tool for risk prediction, including more accurate biomarkers are needed. More...
13 Jul 2016
Image: Researchers have devised a new high-resolution method for studying which genes are active in a tissue. The method can be used on all types of tissue and is valuable to both preclinical research and cancer diagnostics (Photo courtesy of the Karolinska Institutet / the Royal Institute of Technology).

Spatial Transcriptomics Technique Enables Visualization of Gene Expression in Tissues

A team of Swedish researchers has developed a high-resolution method for resolving the transcriptome – the library of active genes and RNAs – in histological samples of patients' tissues. More...
12 Jul 2016
Image: The miScript primer assays and PCR kits (Photo courtesy of Qiagen).

MicroRNAs Predict Disease Progression in Brain Tumors

A new method has been developed of predicting disease progression in glioblastoma patients who have undergone standard treatment and multimodal therapy of glioblastoma (GBM) reveals inter-individual variability in terms of treatment outcome. More...
07 Jul 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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