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Clinical Chemistry

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Sickle Cell Trait Linked to Chronic Kidney Disease Risk

Sickle cell trait is defined as inheritance of a single copy of the sickle mutation that results from a single base pair substitution in the gene encoding the β-globin chain of hemoglobin.   More...
30 Nov 2014

HDL Cholesterol Efflux Capacity a Better Predictor of Cardiovascular Disease Risk Than Measurement of HDL or HDL Cholesterol

A recent paper strengthened the hypothesis that HDL function, rather than the absolute concentration of this lipoprotein, is the key factor linking HDL and cardiovascular disease.   More...
30 Nov 2014
Image:  The Agilent 6890 GC with 5973 Mass Spectrometer and Tekmar Velocity XPT Purge & Trap (Photo courtesy of Gen Tech).

Low Levels of Prohormone Predicts Coronary Heart Disease

The adrenal sex hormone dehydroepiandrosterone, which is present in serum mainly as the sulfate DHEA-S, is the most abundant steroid hormone in human blood and its levels decline dramatically with age.  More...
24 Nov 2014
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Low Density Lipoprotein Apolipoprotein-B Assay Validated

The relationship between apolipoprotein-B concentration and the risk of developing cardiovascular disease is more robust than the relationship between low density lipoprotein cholesterol concentration and CVD.  More...
19 Nov 2014

Saliva Cited as Reservoir of Diagnostically Valuable RNA Species

Saliva has been shown to be a source for several classes of RNA molecules that can provide genomic information, which can be used to diagnose both chronic and acute diseases.  More...
16 Nov 2014
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Fecal Testing Effective for Familial Colorectal Cancer Screening

Fecal immunochemical tests may be as effective as colonoscopies when it comes to detecting colorectal cancer among first-degree relatives of patients with colorectal cancer.   More...
12 Nov 2014
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Criteria Optimized for Microscopy Following Automated Urine Analysis

Urinalysis is one of the most requested routine tests in clinical laboratories and is very useful in screening, diagnosing, and monitoring many diseases and is not limited in scope to diseases directly involving the urinary tract.  More...
05 Nov 2014
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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