Clinical Chemistry
Urine Neutrophil Gelatinase-Associated Lipocalin Predicts Acute Kidney Injury
Despite the increasing heterogeneity of etiology, making a definitive and timely diagnosis of acute kidney injury (AKI) remains challenging. Currently, the diagnosis of AKI is still based on elevated serum creatinine concentration or decreased urinary excretion. However, increased serum creatinine and decreased urine volume usually occur 48 hours after renal injury. More...15 Nov 2022
New Blood Cholesterol Testing System Is Cheaper, More Efficient, and Faster
Scientists have developed a new sensor device for determining cholesterol levels in the blood. The system does not use protein compounds, namely enzymes. Chemists replaced them with an inorganic analogue - copper chloride. This allowed to make the process of creating cholesterol meters cheaper, to make blood testing easier, faster and more accessible. More...08 Nov 2022
New Analyzer Monitors Blood Ammonium Levels at POC to Facilitate Quick Medical Decisions
Researchers have developed an analyzer that monitors the level of ammonium in the patient’s blood using a decentralized method at the POC, instead of sending blood samples to be analyzed in hospital laboratories, where traditional equipment is used. More...04 Nov 2022
Urine Bicarbonate Test Offers Safe Quantification of CFTR Function in Cystic Fibrosis Patients
A study of patients with cystic fibrosis has found that challenged urine bicarbonate excretion may offer a new, simple, and safe quantification of cystic fibrosis transmembrane conductance regulator (CFTR) function and the extent of its pharmacologic improvement. More...02 Nov 2022
Cell-Specific Bioorthogonal Tagging of Glycoproteins Developed
Altered glycoprotein expression is an undisputed corollary of cancer development. Understanding these alterations is paramount but hampered by limitations underlying cellular model systems. For instance, the intricate interactions between tumor and host cannot be adequately recapitulated in monoculture of tumor-derived cell lines. More...31 Oct 2022
AI Combined with Molecule-Making Machine Could Make Complex Chemistry Automated and Accessible
A research team has combined AI, “building-block” chemistry and a molecule-making machine to find the best general reaction conditions for synthesizing chemicals important to biomedical and materials research – a finding that could speed innovation and drug discovery as well as make complex chemistry automated and accessible. More...31 Oct 2022
Lipidomic Determinants Profiled for Human Diabetic Neuropathy
Peripheral neuropathy is a common complication of type 2 diabetes, ranging in prevalence from 10% to over 50% in various cohorts. Peripheral neuropathy symptoms manifest as a loss of sensation and pain in a length-dependent manner. Peripheral neuropathy in type 2 diabetes remains recalcitrant to effective treatment; glucose control only marginally prevents neuropathy onset and development. More...05 Oct 2022
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.