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Clinical Chemistry

Image: Tin dioxide manocrystal sensors for volatile organic compounds (VOC) detection. (Top) – Schematic representation of the SnO2 nanorod sensor for VOC detection. (Bottom) – Sensor response in relation to pore size for 100 ppm ethanol gas changes by 5 orders of magnitude at 250 degrees Celsius (Photo courtesy of Professor Tetsuya Kida, Kumamoto University / ACS).

Novel Approach Enables Ultrasensitive Detection of Volatile Organic Compounds

By a pore tuning approach using anisotropically shaped sno2 nanocrystals, scientists have developed highly sensitive gas sensors for volatile organic compound (VOC) detection. More...
14 Feb 2017
Image: A structural model of human prostate specific antigen (PSA) with bound substrate complexed with antibody (Photo courtesy of Wikimedia Commons).

Genome Study Strengthens Value of PSA Screening as Diagnostic Tool

Results of a genome-wide association study (GWAS) of prostate specific antigen (PSA) may lead to improvements that will increase the usefulness of measuring this biomarker for diagnosis of prostate cancer. More...
14 Feb 2017
Image: The Triple Time-Of-Flight 5600 Mass Spectrometer (Photo courtesy of Sciex).

Blood Test May Help Predict Confusion Post-Surgery

Many people experience an extended period of confusion when they awake after surgery and this acute confusional state, called delirium, particularly affects older adults and poses an important clinical challenge as it can lead to greater postoperative complications and may extend hospitalization. More...
09 Feb 2017
Image: A transmission electron photomicrograph (TEM) revealed the presence of coxsackievirus virus particles, which were found within a specimen of muscle tissue (Photo courtesy of Dr. Fred Murphy and Sylvia Whitfield).

Enterovirus Infections Linked with Autoimmunity Leading to Diabetes

Type 1 diabetes is caused by an immune-mediated process that damages insulin-producing beta cells in the pancreas and the subclinical phase of the disease can be identified by detecting autoantibodies. More...
02 Feb 2017
Image: The Nexera ultra high performance liquid chromatograph (UHPLC) system (Photo courtesy of Shimadzu).

Blood Test for Gut Bacteria Predicts Cardiovascular Events

The bacteria that inhabit the gut digest food and produce metabolites that can have a marked effect on the heart and blood vessels. A molecule called trimethylamine N-oxide (TMAO) could predict this risk not only in the short-term but also the risk of death in the longer term. More...
02 Feb 2017
Image: Researchers have developed an extended fatty liver index (FLI) that can better diagnose fatty liver and better determine the probability of reducing liver fat content during a lifestyle intervention (Photo courtesy of Institute for Diabetes Research and Metabolic Diseases, Germany).

New Index Generated for Diagnosing Non-Alcoholic Fatty Liver Disease

Based on clinical data, researchers have generated a new fatty liver index (FLI) that can predict the presence of fatty liver disease (FLD) with high accuracy, enabling development of an extended, more effective diagnostic index for nonalcoholic fatty liver disease (NA-FLD), which has become an epidemic in industrialized countries. More...
31 Jan 2017
Image: The Cerilliant certified reference materials now include the first CE-marked calibration kit to enable broad-range diagnostic testosterone testing in men, women, and children (Photo courtesy of Merck).

Calibration Kit Introduced for IVD Testing of Testosterone

The first CE-marked calibration kit for more sensitive testosterone measurement in men, women, and children, provides a wide analytical range and increased accuracy at low levels. More...
31 Jan 2017
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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