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Clinical Chemistry

Image: Midazolam, a drug used to give symptom relief in palliative care to terminal patients (Photo courtesy of WebMD).

Blood Test Predicts How Long Cancer Patients Will Survive

Survival evaluations can determine whether or not pharmacological treatment should be given. Cytotoxic chemotherapy would rarely be prescribed in a patient unlikely to survive beyond several weeks because of unpleasant side effects. More...
05 Jan 2017
Image: A histopathology of a kidney biopsy showing diffuse proliferative lupus nephritis with increased mesangial matrix and mesangial hypercellularity (Photo courtesy of Nephron).

Kidney Biomarkers Investigated to Track Lupus

Lupus is a chronic autoimmune disease in which the body's immune system becomes hyperactive and attacks normal, healthy tissue. This results in symptoms such as inflammation, swelling, and damage to joints, skin, kidneys, blood, the heart, and lungs. More...
04 Jan 2017
Image: A histology of immune cells of the brain, the microglia (brown), cluster around the beta-amyloid deposits (red) in an Alzheimer’s disease model (Photo courtesy of Frank Heppner/ Charité).

Early Signs of Alzheimer's Detected in Cerebrospinal Fluid

An early immune response has been found in individuals with a genetic predisposition to Alzheimer's and their brains showed abnormal immune reactions as early as about seven years before the expected onset of dementia. More...
29 Dec 2016
Image: The BN ProSpec system and nephelometer (Photo courtesy of Siemens Healthcare).

Inflammatory Markers Predict Risk of Morbidity and Mortality

Inflammatory markers are known to be associated with cancer, chronic heart disease and other serious health conditions; however, the marker that is most useful in predicting these diseases continues to be debated. More...
22 Dec 2016
Image: The Hitachi-7600, modular DP-110 autoanalyzer (Photo courtesy of Hitachi).

Change in Serum Bilirubin Level Predicts Incident Metabolic Syndrome

Metabolic syndrome (MetS) is a constellation of interlinked metabolic conditions that seem to accelerate the development of cardiovascular disease. Chronic inflammation, oxidative stress, and insulin resistance all play important roles in the initiation and advancement of MetS. More...
21 Dec 2016
Image: The cobas e 411 fully automated, random access system for immunoassay analysis (Photo courtesy of Roche Diagnostics).

Performance of Second Generation Cortisol Assay Evaluated

Untreated disorders of the adrenocortical system, such as Cushing’s or Addison’s disease, can be fatal, and accurate quantification of a patient’s cortisol levels is vital for diagnosis. A straightforward diagnostic approach is of essential importance, and accurate quantification of cortisol levels plays a key role in the diagnosis of patients with suspected disease. More...
21 Dec 2016

Lower Cut-Off Point of Blood Glucose May Define Prediabetes

Doctors define prediabetes as impaired fasting glucose with a higher than normal blood sugar levels after a period of fasting, impaired glucose tolerance with a higher than normal blood sugar levels after eating, or raised glycosylated hemoglobin levels. More...
15 Dec 2016
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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