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Clinical Chemistry

Image: Photomicrograph of blood smear devoid of platelets from a patient with thrombocytopenia (Photo courtesy of the Icahn School of Medicine at Mount Sinai).

Higher Histone Levels Associated with Thrombocytopenia

Thrombocytopenia is observed in approximately 30% to 40% of patients in the intensive care unit concomitant with poor outcomes and an association with histones has been examined.   More...
09 Mar 2016
Image: The benchtop miniature mass spectrometer system, Mini 12, with ambient ionization source and tandem mass spectrometry capabilities (Photo courtesy of Purdue University).

Lipidomics Method Could Bring Fast Cancer Diagnosis

The field of lipidomics has been significantly advanced by mass spectrometric analysis, but the distinction and quantitation of the unsaturated lipid isomers, however, remain a long-standing challenge.  More...
08 Mar 2016
Image: Dot blots showing the expressions of total glycogen synthase kinase-3β (tGSK-3β) and p-GSK-3β (ser9) in the platelets; the differences of platelet GSK-3β activity between T2DM-nMCI group and T2DM-MCI group (Photo courtesy of Tongji Medical College).

Biomarkers Help Diagnose Mild Cognitive Impairment in Diabetics

Alzheimer's disease is the most common cause of senile dementia, and the prevalence is increasing with population aging and even when the clinical diagnosis of Alzheimer's disease is made, it is generally too late to be curable.  More...
02 Mar 2016
Image: The HiScan SQ scanner (Photo courtesy of Illumina).

Molecular Type 2 Diabetes Biomarker Identified

Type 2 diabetes mellitus is an established risk factor for a wide range of vascular diseases, including ischemic stroke as well as heart attacks, neuropathy and blindness.    More...
23 Feb 2016
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Fecal Analyses Leads to Inflammatory Bowel Disease Diagnosis

The development of sophisticated analytical techniques has enabled the study and interpretation of changes in the fecal volatile organic metabolites and its correlation with the pathophysiological mechanisms in the gut during health and disease.  More...
23 Feb 2016
Image: The Architect Immunoassay analyzer used for measuring 25-hydroxyvitamin D3 (25OHD3) (Photo courtesy of Abbott Diagnostics).

Separator Tubes Assessed for Measurement of 25-Hydroxyvitamin D3

The accuracy of 25-hydroxyvitamin D3 measurement on specimens collected into serum separator tubes has been questioned because of possible interference by the gel.  More...
17 Feb 2016
Image: A phlebotomist examining a blood sample to be used for multiple tests ordered by the physician (Photo courtesy of University of Utah Medical Center).

Multifaceted Intervention Reduces In-Patient Laboratory Costs

A tool called Value Driven Outcomes has been developed to reduce superfluous laboratory testing and when integrated into a quality improvement initiative laboratory costs decreased by nearly 10% per visit.  More...
16 Feb 2016
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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