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Clinical Chemistry

Image: The AxSYM automated immunoassay diagnostic analyzer system (Photo courtesy of Abbott Laboratories).

Diagnostic Accuracy Compared for Biomarkers of Acute Heart Failure

Candidate biomarkers in cardiac disease include the proteins galectin-3, soluble ST2 (sST2) and B-type natriuretic peptide (BNP), but their prognostic value in acute heart failure is uncertain. More...
25 Jan 2017
Image: The ABSOGEN PCT assay: control line (C) and test line (T) of the semi-quantitative kit for the procalcitonin analysis. Negative (

Novel Point-Of-Care Test Kit for Procalcitonin Evaluated

In response to inflammation, procalcitonin plasma concentrations increase more rapidly than other acute-phase reactants and higher values are associated with severe disease. Procalcitonin measurements assist in determining whether antibiotic therapy should be used. More...
25 Jan 2017
Image: The LUMIPULSE G1200 is a robust mid-sized fully automated immunoassay instrument (Photo courtesy of Fujirebio Diagnostics).

Novel Procalcitonin Immunoassay Analytically Evaluated

The exact definition of sepsis has changed considerably over time, and remains controversial. This is probably due to the fact that sepsis develops as a continuum of severity, ranging from local infection, through bloodstream propagation to septic shock. More...
25 Jan 2017
Image: The M40 automatic chemistry analyzer for HbA1c (Photo courtesy of Hitachi).

Positive Fecal Occult Blood Test Associated with Diabetes

Numerous etiologies are implicated in the complications of diabetes and a link between diabetes and the predisposition to certain cancers, including colon cancer, has been established during the last decade. More...
25 Jan 2017
Image: A ball-and-stick model of the testosterone molecule (C19H28O2) as found in the crystal structure of testosterone monohydrate (Photo courtesy of Wikimedia).

New Defined Reference Range for Testosterone Levels Established

Through a landmark study based on cohorts in the USA and Europe, researchers have established a harmonized reference range for testosterone levels in men to help limit misdiagnoses and unnecessary treatments. This can be particularly helpful in identifying patients with hypogonadism, as the lack of both defined reference ranges of testosterone and of standardization of hormone assays has made diagnosing hypogonadism a difficult task. More...
24 Jan 2017
Image: A micrograph showing cells with abnormal p53 expression (brown) in a brain tumor (Photo courtesy of Wikimedia Commons).

Novel Biosensor Selectively Measures Cancer Patient p53 Autoantibodies

A team of Spanish cancer researchers has developed a disposable electrochemical biosensor for the specific and sensitive determination of p53-specific autoantibodies, which are biomarkers for certain types of cancers with p53 gene mutations. More...
24 Jan 2017
Image: Only a few microliters of tears are needed to analyze the vitamins in them (Photo courtesy of Sarah Bird, Michigan Technological University).

Comparison of Vitamin Concentrations in Tears and Serum

Results obtained during a recent study suggest that tears could be used as specimens to monitor nutritional health, since they are easily obtained, sufficiently mirror blood serum data, and enhance the speed of deficiency diagnoses. More...
24 Jan 2017
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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