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Clinical Chemistry

Image: The cumulative incidence of dementia according to lipid concentrations (triglycerides, HDL-C, LDL-C, total cholesterol) (Photo courtesy of the University of Bordeaux).

Plasma Lipids Associated Differently with Dementia Incidents

Dementia refers to a group of neurological disorders characterized by memory loss, cognitive impairment, and disability in activities of daily living. As the primary risk factor for dementia is old age, the prevalence of dementia is increasing dramatically with aging populations worldwide. More...
12 Apr 2017

Test Panel Improves Prediction of Heart Disease Risk

Researchers have found that combined results from 5 simple tests – an EKG, a limited CT scan, and three blood tests – better predicted who would develop heart disease compared with standard strategies that focus on blood pressure, cholesterol, diabetes, and smoking history. More...
11 Apr 2017
Image: The LCQ tandem mass spectrometer (Photo courtesy Thermo Fisher Scientific).

Biochemical Method Diagnoses Autism in Children

The number of diagnosed cases of Autism Spectrum Disorders (ASD) has increased dramatically over the last four decades; however, there is still considerable debate regarding the underlying pathophysiology of ASD. More...
07 Apr 2017
Image: The Easy-nLC 1000 liquid chromatography system (Photo courtesy of Thermo Fisher Scientific).

Phosphoproteins Identified as Biomarkers for Cancer

The state of protein phosphorylation can be a key determinant of cellular physiology such as early stage cancer, but the development of phosphoproteins in biofluids for disease diagnosis remains elusive. More...
05 Apr 2017

Simple Urine Test Helps Track ALS Progression

The continued failure of amyotrophic lateral sclerosis (ALS) clinical trials and the absence of therapeutic options for this fatal disease have fueled interest in the prospect that biomarkers may hold great promise for advancing therapy development efforts. More...
05 Apr 2017
Image: The Combur 10 urinalysis test strips (Photo courtesy of Roche).

Early Serum Creatinine Predicts Post-Surgery AKI

Acute Kidney Injury (AKI) is a common and serious complication of cardiac surgery. Mild AKI occurs in nearly one in five patients undergoing cardiac surgery and is associated with a 19-fold increase in short-term mortality. More...
05 Apr 2017
Image: A transmission electron micrograph (TEM) of a mesenchymal stem cell displaying typical ultrastructural characteristics (Photo courtesy of Robert M. Hunt).

Organ Cells Derived from Stem Cells May Predict Drug Sensitivity

Testing the drug pazopanib on liver-like cells derived from patient-specific stem cells, researchers have shown first proof-of-concept for a new approach that could lead to development of personalized drug-toxicity assays for patients. More...
29 Mar 2017
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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