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Clinical Chemistry

Image: A histopathology of extensive hepatocyte necrosis seen here in a case of paracetamol overdose. The hepatocytes at the right are dead, and those at the left are dying. This pattern can be seen with a variety of hepatotoxins (Photo courtesy of the University of Utah Medical School).

Test Detects Overdose Patients at Risk of Liver Damage

Paracetamol is a safe analgesic drug when taken at therapeutic doses; however, in overdose, paracetamol is hepatotoxic and is the most common cause of acute liver failure in the USA and Europe. More...
28 Nov 2017
Image: Diagram of DiviTum sTK1 assay: BrdUTP is subsequently incorporated into a solid-phase DNA-strand. Incorporated BrdU is detected using an anti-BrdU monoclonal antibody conjugated to the signal generating enzyme alkaline phosphatase. The level of BrdU incorporated over time is proportional to the level of thymidine kinase activity in the sample (Photo courtesy of Biovica).

Blood Test Reduces Interim for Evaluating Cancer Treatment

Although prognosis and treatment of metastatic breast cancer (MBC) have improved over the last years, there is still an unmet clinical need for more precise prognostic and treatment monitoring tools. More...
27 Nov 2017
Image: A scanning electron photomicrograph (SEM) of prostate cancer cells (Photo courtesy of Prostate Cancer UK).

Low Testosterone Men Less Likely to Have Prostate Cancer

Prostate cancer affects more than 170,000 men each year in the USA, of who almost 30,000 die from the disease. While it is not yet known what causes the condition, a number of risk factors have been identified, such as age, ethnicity, and genetic mutations. More...
24 Nov 2017
Image: Variations in phosphate levels in the blood may pose risk to cardiovascular health (Photo courtesy of Dr. Steve Petryk).

Low Serum Phosphate Linked to Risk of Heart Attack

Cardiovascular disease is a leading cause of mortality and morbidity worldwide, and high serum phosphate is an established risk factor for coronary artery disease, particularly in patients with chronic kidney disease. More...
22 Nov 2017
Image: Enzyme-linked immunosorbent assay (ELISA) kits for the measurement of fecal and serum zonulin (Photo courtesy of DRG International).

Fecal Zonulin Elevated in Crohn’s Disease and Smokers

Human zonulin is a protein that increases permeability in the epithelial layer of the small intestine by reversibly modulating the intercellular tight junctions. There is not sufficient information available about zonulin's participation in inflammatory bowel diseases (IBD). More...
20 Nov 2017
Image: The UF-1000i automated urine particle analyzer (Photo courtesy of Sysmex).

Urine Particle Analyzer Compared with Standard Methods

Urinary tract infections (UTIs) are characterized by the presence of microbial pathogens within the urinary tract, and they represent one of the most common infections identified in both hospitalized and clinic patients. Most UTIs are easily treated without difficulty. More...
20 Nov 2017
Image: The LC UltiMate 3000 high performance liquid chromatography (HPLC) system coupled with an LTQ Velos Pro mass spectrometry system (Photo courtesy of Thermo Fisher Scientific).

New Methods Developed to Diagnose TB and HIV

The bacteria responsible for tuberculosis (TB) can lurk in a person's lung tissue for decades before producing active, infectious TB disease and it is estimated that a third of the global population may have such dormant infections, with 5% to 10% progressing to active disease. Detecting TB is notoriously challenging. More...
15 Nov 2017
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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