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Clinical Chemistry

Image: Histology of the brain, showing infarct and hemorrhage due to ruptured saccular aneurysm and thrombosis of right middle cerebral artery (Photo courtesy of Peter Anderson).

Biomarker Used for Febrile Intracranial Hemorrhage Patients

Procalcitonin (PCT) is a biomarker that exhibits greater specificity than other proinflammatory markers, such as cytokines, in identifying patients with sepsis and can be used in the diagnosis of bacterial infections. More...
27 Jun 2018
Image: Duolink proximity ligation assay technology extends the capabilities of traditional protein techniques (Photo courtesy of Olink Proteomics).

Genomic Atlas of Human Plasma Proteome Publicized

Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. More...
26 Jun 2018
Image: The UniCel Dxl 800 Access 2 immunoassay system (Photo courtesy of Beckman Coulter).

Blood Biomarkers Help Diagnose Obstructive Sleep Apnea

The relationship between obstructive sleep apnea (OSA) and blood biomarkers has been assessed and the hypothesis tested that combinations of markers provide a characteristic OSA signature with diagnostic screening value. More...
26 Jun 2018
Image: The Elecsys high-sensitivity cardiac troponin T (hs-cTnT ) assay (Photo courtesy of Roche Diagnostics).

Cardiac Infarction Diagnosed with Sensitive Method

Chest pain is one of the most common reasons people seek emergency medical care. To determine if a person has suffered a cardiac infarction, symptoms are assessed partly on the basis of chest pain and partly with an electrocardiogram taken to detect typical changes consistent with a heart attack. More...
24 Jun 2018
Image: A radiograph of 50-year-old patient with a well-placed acetabular cup against the tear drop and well placed femoral stem; after seven years, the patient has developed extensive osteolysis (Photo courtesy of Duke University Medical Center).

Urinary Markers Predict Bone Problems after Hip Replacement

Osteolysis is an active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification. Although osteoclasts are active during the natural formation of healthy bone the term "osteolysis" specifically refers to a pathological process. More...
20 Jun 2018
Image: The FLOUstar optima plate reader (Photo courtesy of BMG Labtech).

Link Identified between Inflammation and Depression

It is well established that people with both type-1 and type-2 diabetes have an increased risk of developing depression, a debilitating mental health disorder with potentially serious consequences, but the causes remain poorly understood. More...
20 Jun 2018
Image: A blood test for Vitamin D, where deficiency may indicate higher plasma lipid levels (Photo courtesy of bluehorizon).

High Vitamin D Levels Linked to Lower Cholesterol

Vitamin D is known to be essential for bone metabolism, and low serum 25(OH)D levels increase the risk of rickets, osteomalacia, and osteopenia. The associations of serum 25-hydroxyvitamin D (25(OH)D) with plasma lipids remain controversial in children. More...
19 Jun 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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