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Clinical Chemistry

Image: An illustration of individual breast cancer tumors (Tumors A–D) with cells in varying differentiation states (shown in different colors) within a tumor (Image courtesy of Yeo SK and Guan J-L / Trends in Cancer).

Single-Cell Diagnostics Advocated for Breast Cancer Subtyping

In an opinion article based their analysis of studies, two medical researchers argue that women diagnosed with breast cancer (BC) would likely benefit from treatment based also on identifying the molecular subtype of different cells within their tumors, in addition to current molecular and histopathology testing of collections of tumor cells. More...
06 Nov 2017
Image: The ABI 3730xl capillary DNA sequencer (Photo courtesy of Thermo Fisher Scientific).

Genetic Mutation Linked to New Form of Diabetes

Finding the genetic cause of rare familial diabetes (monogenic diabetes) provides new biological insights into human pancreas development and function, as well as potentially novel therapeutic targets with important treatment implications. More...
02 Nov 2017
Image: Samples of human blood collected for testing; excessive testing may cause hospital-acquired anemia (Photo courtesy of Rebecca Zeffert).

Experts Recommend Fewer Tests for Hospitalized Patients

Routine daily laboratory testing of hospitalized patients reflects a wasteful clinical practice that threatens the value of health care. Initiatives from numerous professional societies have identified repetitive laboratory testing in the face of clinical stability as low value care. More...
31 Oct 2017
Image: The hema-Screen Specific kit for the rapid and qualitative determination of Occult Human Blood in fecal samples (Photo courtesy of Immunostics).

Fecal Hemoglobin Stability Evaluated for FITs

Screening with guaiac-based fecal occult blood tests (gFOBT), followed by colonoscopy for patients who test positive, has been associated with a reduction of 15% to 33% in colorectal cancer (CRC)–related mortality. More...
31 Oct 2017
Image: Box‐and‐whisker plot comparisons between nonsurvivors (n=8) and survivors (n=35) by: (A) body mass index, (B) maximal inspiratory pressure, and (C) N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) (Photo courtesy of Cheeran D et al, 2017, Journal of the American Heart Association).

Risk Factors Identified for Duchenne Muscular Dystrophy-Associated Cardiomyopathy

Researchers have now identified important factors associated with death, thus highlighting a high‐risk DMD population with a worse cardiovascular and overall prognosis. More...
30 Oct 2017
Image: A positive pregnancy test; Women with test results indicating low ovarian reserve were no less likely to conceive within six or 12 months of attempts than women whose laboratory tests did not point to a limited egg supply (Photo courtesy of News Health Advisor).

Ovarian Reserve Tests Prove Poor Predictors of Fertility

Tests that measure a woman’s “ovarian reserve” to estimate how many more years of fertility she has have grown increasingly popular, yet despite the lack of evidence of their utility, biomarkers of ovarian reserve are being promoted as potential markers of reproductive potential. More...
24 Oct 2017
Image: Research shows individuals with lower levels of calcium in the blood are more likely to experience SCA than those with higher calcium levels (Photo courtesy of SPL).

Low Serum Calcium Increases Risk of SCA

Sudden cardiac arrest (SCA) is fatal for over 90% of patients, and more than half of men and close to 70% of women who die of SCA have no clinical history of heart disease prior to this cardiac event. It is one of the leading causes of death in the USA and kills more people than any single cancer. More...
19 Oct 2017
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.