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Clinical Chemistry

Image: The ACQUITY UPLC I-Class / Xevo TQ-S IVD system (Photo courtesy of Waters).

Lipidome Tested As Predictor in T2DM Progression

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by hyperglycemia, which results from impaired insulin secretion of pancreatic β-cells and from ineffective cellular response to insulin. More...
11 Jan 2018
Image: The skin-like biosensor system developed for noninvasive blood glucose monitoring (Photo courtesy of Tsinghua University).

Biosensor System Developed for Blood Glucose Monitoring

Currently, noninvasive glucose monitoring is not widely appreciated because of its uncertain measurement, accuracy, weak blood glucose correlation and inability to detect hyperglycemia/hypoglycemia during sleep. More...
11 Jan 2018
Image: The SimulToF matrix assisted laser desorption/ionization time of flight mass spectrometer (Photo courtesy of Virgin Instruments).

Protein Signature Associated with Outcome in Metastatic Melanoma

Clinical results in metastatic melanoma with the antibodies nivolumab and pembrolizumab to anti– programmed cell death protein 1 (PD-1) have led to clinically and statistically significant improvements in progression-free and overall survival compared to alternative first- and second-line therapies. More...
10 Jan 2018
Image: The ARCHITECT i2000SR immunoassay analyzer (Photo courtesy of Abbott Diagnostics).

Stability of Cardiac Biomarkers Tested in Different Samples

Blood-based biomarkers, such as cardiac troponin (cTn) and galectin-3, are widely used in clinical trials and/or in clinical routines as an aid for the diagnosis and risk stratification of patients with heart disease. More...
09 Jan 2018
Image: The Cobas 6000 modular analytical system (Photo courtesy of Roche).

Lipid Biomarker Concentrations Associated with CVD Risk

Circulating concentrations of lipid biomarkers are consistently associated with cardiovascular disease (CVD) events and thus are considered major indicators of metabolic health, but the evidence for a relationship with cancer risk, however, is not entirely consistent. More...
08 Jan 2018
Image: The BCS XP System, one of the most widely used fully automated hemostasis analyzers (Photo courtesy of Siemens Healthineers).

Comprehensive Metabolic Profiling Assessed for Chronic Inflammation

Inflammation is a corporeal response to damaging stimuli associated with the activation of various molecular mechanisms. Both the local and systemic responses initiated by an inflammatory process indicate an imbalance in metabolism in the tissues affected. More...
08 Jan 2018
Image: The fractional exhaled nitric oxide (FeNO) concentration test is a quick and simple test and a valuable tool to assist in the diagnosis of asthma (Photo courtesy of Talkhealth Partnership).

Exhaled Nitrous Oxide Adjunct Test Diagnoses Asthma

Although about 24 million Americans are diagnosed with asthma every year, there is no single test that can diagnose the disease and common symptoms, such as shortness of breath, wheezing, and cough, are relatively nonspecific. More...
04 Jan 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.