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Clinical Chemistry

Image: A blood test for vitamin D; insufficiency is linked to miscarriage among women with prior pregnancy loss (Photo courtesy of Blood Tests London).

Insufficient Vitamin D Linked to Miscarriage with Prior Loss

Vitamin D deficiency during pregnancy is associated with adverse pregnancy outcomes, although the association between preconception vitamin D concentrations and live birth is unknown. More...
14 Jun 2018
Image: Testosterone/estradiol ratio and the risk of cardiovascular disease, coronary heart disease and heart failure (HF) in post-menopausal women (Photo courtesy of Johns Hopkins Medicine).

Hormone Levels Alter CVD Risk in Older Women

Higher androgen and lower estrogen levels are associated with cardiovascular disease (CVD) risk factors in women; however, studies on sex hormones and incident CVD events in women have yielded conflicting results. More...
13 Jun 2018
Image: The Simoa single molecule array HD-1 analyzer (Photo courtesy of Quanterix).

Biomarkers Evaluated for Subconcussive Head Trauma

Repetitive subconcussive head trauma is a consequence of participation in contact sports and may be linked to neurodegenerative diseases. The degree of neurological injury caused by subconcussive head trauma is not easily detectible, and this injury does not induce readily identifiable clinical signs or symptoms. More...
12 Jun 2018
Image: The Vidas BRAHMS procalcitonin assay is performed on the benchtop Vidas multiparametric immunoassay instrument (Photo courtesy of bioMérieux).

Procalcitonin Guides Use of Antibiotics for Respiratory Infections

The overuse of antibiotic agents is a public health problem associated with increased health care costs and antibiotic resistance. Overuse of antibiotics is common in infections of the lower respiratory tract, where bacterial and viral infections manifest similarly. More...
12 Jun 2018
Image: The relationship between delay in initial lactate measurement and the probability of in-hospital mortality for patients meeting SEP-1 criteria, stratified by level of initial lactate value (mmol/L) and adjusted for patient location, eCART score, and lactate value (Photo courtesy of University of Chicago).

Earlier Measurements Offer Quicker Treatment for Sepsis

Sepsis remains a significant cause of morbidity and mortality in the USA, leading to the implementation of the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1). SEP-1 identifies patients with “severe sepsis” via clinical and laboratory criteria and mandates interventions, including lactate draws and antibiotics, within a specific time window. More...
07 Jun 2018
Image: A pregnant woman with a stethoscope placed to her stomach. Scientists have developed a test to predict a woman\'s risk of preterm birth (Photo courtesy of University of California - San Francisco).

New Test Predicts Risk of Preterm Birth

A test has been developed to predict a woman's risk of preterm birth when she is between 15 and 20 weeks pregnant, which may enable doctors to treat them early and prevent severe complications later in the pregnancy. More...
06 Jun 2018
Image: The Access 2 benchtop immunoassay system (Photo courtesy of Beckman Coulter Diagnostics).

Vitamin D Levels Associated with Type 2 Diabetes

The incidence of type 2 diabetes has increased substantially in both high-income and low- and middle-income countries in recent decades. Observational studies have reported that higher plasma 25-hydroxyvitamin D (25[OH]D) concentrations are associated with lower risks of diabetes, but it is unclear if these associations are causal. More...
06 Jun 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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