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Clinical Chemistry

Typical GC-IMS output of a vaginal swab. Red spots indicate individual chemicals and machine learning identifies which of these chemicals hold discriminatory information (Photo courtesy of the University of Warwick).

New Technique Predicts Preterm Births in High Risk Women

Globally, preterm birth is the leading cause of death in children under 5 years with 15 million babies being born before 37 weeks’ gestation each year. Spontaneous preterm birth is a syndrome, which can be precipitated by a variety of factors. More...
14 Aug 2020
The AB MDS SCIEX API4000 tandem mass spectrometer (Photo courtesy of SCIEX).

Dolichol Biomarker Evaluated for Congenital Disorders of Glycosylation

A congenital disorder of glycosylation (CDG; previously called carbohydrate-deficient glycoprotein syndrome) is one of several rare inborn errors of metabolism in which glycosylation of a variety of tissue proteins and/or lipids is deficient or defective. More...
14 Aug 2020
Image: The Xevo mass spectrometer with an Acquity ultra high performance chromatography system (Photo courtesy of Waters Corporation).

Simple Urine Test Significantly Improves Detection of Adrenal Cancer

Prognosis for patients discovered to have an adrenal cortical carcinoma (ACC), a cancerous adrenal mass, is poor, and a cure is only achievable through early detection and surgery. The incidental discovery of an adrenal mass often triggers additional scans to determine whether the mass is cancerous. More...
06 Aug 2020
Image: The Quantikine ELISA Human Lipocalin-2/NGAL Kit is a solid phase sandwich ELISA that quantifies human Lipocalin-2/NGAL in serum, heparin plasma, saliva, and urine (Photo courtesy of R&D Systems).

Lipocalin 2 Proposed as Biomarker for Bacterial Meningitis

Central nervous system (CNS) infections cause significant mortality and morbidity worldwide. Common CNS infections include bacterial meningitis (BM) other than tuberculosis, viral encephalitis, tuberculous meningitis (TBM) and cryptococcal meningitis, but there are more than 100 documented infectious causes of CNS infections. More...
05 Aug 2020
Image: A kit for measuring beta-hydroxybutyrate as a biomarker for diabetic ketoacidosis (Photo courtesy of BioSystems).

Protracted Ketonemia Reported in Hyperglycemic COVID-19 Emergencies

Diabetes is a major contributor to disease severity and mortality in patients with COVID-19; with an estimated 3.5-times increase in risk of death during hospital admission for patients with type 1 diabetes, and 2.03-times for those with type 2 diabetes. More...
03 Aug 2020
Image: Micro Mass Quattro Premier Mass Spectrometer (Photo courtesy of University of Massachusetts Amherst).

Plasma Lipidome Investigated in Hereditary Hemochromatosis

Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder with increased intestinal iron absorption which leads to iron overload and consequently to tissue damage and functional impairment of organs like liver, pancreas, and heart. More...
28 Jul 2020
Image: Alternative indices of high-density lipoprotein (HDL) quality, such as cholesterol efflux capacity, and HDL quantity, such as HDL particle number predict cardiovascular disease risk (Photo courtesy of Harvard Medical School).

Different Ways of Measuring HDL Predicts Cardiovascular Disease

High-density lipoprotein (HDL) cholesterol is a well-integrated biomarker of cardiometabolic health and remains a key component of the cardiovascular disease (CVD) risk prediction algorithms used to guide therapy. More...
21 Jul 2020
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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