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Clinical Chemistry

Image: The BD Biosciences FACS Vantage Flow Cytometer System (Photo courtesy of Hospital for Special Surgery).

Plasma Serglycin Levels Evaluated for Diabetic Retinopathy Diagnosis

Diabetic retinopathy (DR), a microvascular complication caused by chronic diabetes mellitus (DM), is a significant threat to vision in adults, which may even lead to blindness and retinal detachment. The clinical symptoms of DR include fibrosis, capillary obstruction, neovascularization, and increased vascular permeability. More...
04 Jan 2021
Image: The IMMAGE 800 protein chemistry analyzer (Photo courtesy of Beckman Coulter).

Novel Biomarkers Predict the Development of Incident Heart Failure

 Heart failure (HF), caused by abnormal cardiac structure and function, represents the end stage of several cardiac diseases, and significantly worsens both quality of life and life expectancy with a five year survival rate of approximately 50%. Lifetime risk of the development of HF is 20% and overall prevalence 2%. More...
30 Dec 2020
Image: Blood glucose monitor showing a higher than normal result that could lead to hyperglycemia (Photo courtesy of Diabetes Self-Management).

Hyperglycemia and Hypoglycemia Associated with Poor Outcomes in COVID-19 Patients

Diabetes and hyperglycemia have emerged as important risk factors for hospitalization, disease severity, acute kidney injury, acute respiratory distress syndrome, intensive care unit (ICU) admissions, and death in patients with coronavirus disease 2019 (COVID-19). More...
28 Dec 2020
Image: Schematic illustration of the immuno‐infrared sensor. Using oligoclonal capture antibodies, all TDP‐43 isoforms are extracted out of CSF (Photo courtesy of Ruhr University Bochum).

Novel Biomarker Candidate for Amyotrophic Lateral Sclerosis Explored

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease causing a rapid loss of motor function, which usually results in a serious condition with early death within a few years. So far, early and precise diagnosis of the disease has been difficult. More...
23 Dec 2020
Image: The GSP instrument is a high throughput batch analyzer intended for quantitative or qualitative measurement of neonatal screening samples on 96-well microplates (Photo courtesy of PerkinElmer).

Biomarker Evaluated for Early Detection of Congenital Heart Disease

Congenital heart disease (CHD) is the most common congenital malformation in humans worldwide. Circulating cardiovascular biomarkers could potentially improve the early detection of CHD, even in asymptomatic newborns. More...
16 Dec 2020
Image: Microneedle patches containing micron-scale needles are used to create temporary pores in the skin through which interstitial fluid can be extracted (Photo courtesy of Allison Carter, Georgia Tech).

Interstitial Fluid Sampled from Skin Using a Microneedle Patch

Biochemical information about the body most commonly comes from analysis of blood, which represents only 6% of bodily fluids, but valuable information may also be found in other bodily fluids that are traditionally hard to get. Biofluids such as saliva, blood, urine, tears, and interstitial fluid (the fluid that surrounds cells) contain proteins and can be isolated for health monitoring. More...
10 Dec 2020
Image: Histopathology of a cirrhotic liver.  High-density lipoprotein cholesterol predicts survival in cirrhotic patients with acute gastrointestinal bleeding (Photo courtesy of Loyola University Chicago).

HDL-Cholesterol Predicts Survival in Cirrhotic Patients with Gastrointestinal Bleeding

Liver cirrhosis is an important cause of morbidity and mortality as a consequence of continuous liver injuries. Acute gastrointestinal bleeding is a serious complication and critical clinical event in cirrhotic patients. Hepatitis B virus (HBV) is the leading cause of liver cirrhosis in China. More...
10 Dec 2020
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.