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Clinical Chemistry

Image: The Lumipulse G β-amyloid 1-40 assay kit (Photo courtesy Fujirebio)

APOE Gene Influences Alzheimer's Symptoms, Biomarkers in Down Syndrome

Individuals with Down syndrome (DS) constitute a population at ultrahigh risk of developing Alzheimer disease (AD) because of trisomy of chromosome 21, which harbors the amyloid precursor protein (APP) gene. More...
22 Jul 2021
Image: The ROCHE Cobas 6000 Chemistry Analyzer (Photo courtesy of Roche Diagnostics)

Elevated PlGF Levels Found with Acute Fatty Liver of Pregnancy

Acute fatty liver of pregnancy (AFLP) is a severe liver disorder unique to pregnancy, typically occurring after 30 weeks’ gestation. Although uncommon, with an estimated global incidence of 1 in 7,000 to 15,000 pregnancies, AFLP is a life-threatening disease for both mother and child. More...
22 Jul 2021
Image: The VITROS ECiQ Immunodiagnostic System (Photo courtesy of Ortho Clinical Diagnostics)

Novel Adipokine Biomarker Reported for Insulin Resistance and Atherosclerosis

Diabetes Mellitus is a chronic condition occurring due to inadequate production or inadequate action of insulin, ultimately leading to hyperglycemia. Prediabetes, regarded as a precursor of diabetes, is a condition with elevated plasma glucose above normal levels, but below that of clinical disease. More...
21 Jul 2021
Image: Elevated levels of two inflammatory proteins, IL-12p70 and IFN-γ, were associated with slower cognitive decline in older adults (Photo courtesy of Scientific Animations Inc)

Two Inflammatory Proteins Linked with Slower Cognitive Decline

Previous meta-analyses of case-control and prospective cohort studies showed that cytokines and inflammatory markers, such as interleukin-6 (IL-6), C-reactive protein (CRP), and others are elevated in Alzheimer's dementia cases and predicted incident of all-cause dementia. More...
08 Jul 2021
Image: Histology of acute pancreatitis. Microscopically, the fat necrosis consists of steatocytes (adipocytes) that have lost their nuclei and whose cytoplasm has a granular pink appearance as seen on the right. Some hemorrhage is seen at the left in this case of acute pancreatitis (Photo courtesy of Texas A&M University)

Biomarkers Diagnose and Predict Acute Pancreatitis

Acute pancreatitis (AP) is an inflammatory reaction caused by the activated pancreatic enzymes in the pancreas, which leads to subsequent pancreatic autodigestion, edema, hemorrhage, necrosis, and even distal organ dysfunction. More...
08 Jul 2021
Image: Enzyme-linked immunosorbent assay (ELISA) kit for Fatty acid-binding proteins 4 (FABP4) (Photo courtesy of Biovendor R&D)

FABP4 Concentrations Quantified in Proliferative Diabetic Retinopathy

Proliferative diabetic retinopathy (PDR), a progressive and serious stage of diabetic retinopathy (DR) due to retinal ischemia, is characterized by neovascularization (NV), vitreous hemorrhaging (VH) and tractional retinal detachment (TRD), all of which are major causes of blindness in patients with diabetes mellitus (DM). More...
07 Jul 2021
Image: The IDS-iSYS Multi-Discipline Automated System Analyzer (Photo courtesy of Immunodiagnostic Systems)

Two Immunoassays Compared for Determination of Serum Vitamin D

Vitamin D is a fat-soluble steroid prohormone that is generated mainly in the skin by photochemical conversion of 7-dehydrocholesterol. 25-hydroxyvitamin D (25(OH)D) is its main storage form and is present in blood at very high concentration with respect to the active form 1,25-dihydroxyvitamin D. More...
06 Jul 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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