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Clinical Chemistry

Image: The XN-9000 Automated Hematology Analyzer (Photo courtesy of Sysmex Corporation).

Diagnostic Assays Evaluated for Vitamin B12 and Folate Deficiency

Current guidelines pertaining to diagnosing macrocytic anemia in association with vitamin B12 and folate deficiency recommend that vitamin B12, folate, homocysteine, and methylmalonic acid assays should be assessed concurrently due to their close relationship in metabolism. More...
07 Dec 2020
Image: The Spark 10-M multimode reader performs accurate and sensitive measurements of fluorescent cell-based assays (Photo courtesy of Tecan Group Ltd).

Kininogen-1 Protein Linked to Early Cognitive Impairment in Parkinson’s

Cognitive impairment is a common feature in Parkinson's disease (PD), associated with increased morbidity and mortality. An ongoing area of PD studies is the search for biomarkers that can provide prognostic information about cognitive impairment and other symptoms. More...
03 Dec 2020
Image: The Luminex MAGPIX Instrument System (Photo courtesy of Thermo Fisher Scientific).

Single-Tube Multimarker Assay Estimates Preeclampsia Risk

The challenge in the clinical practice of pregnancy monitoring is to distinguish isolated gestational hypertension or proteinuria from the development of preeclampsia (PE) with potential severe consequences to the mother and unborn child. More...
03 Dec 2020
Image: The ABL800 FLEX blood gas analyzer measures a full panel of up to 18 STAT parameters on the same blood sample (Photo courtesy of Radiometer).

Spot Urine Sample Evaluated for Renal Potassium Loss

Hypokalemia is characterized by low serum potassium concentrations. Severe hypokalemia can be life threatening, and immediate potassium replacement is often required to prevent sudden cardiac arrest. More...
02 Dec 2020
Image: An ELISA kit for measuring gastric inhibitory polypeptide (GIP) (Glucose-dependent insulinotropic polypeptide) (Incretin hormone) in human sera (Photo courtesy of RayBiotech Life).

Incretin Hormone Levels Linked to Arteriosclerosis

While existing evidence supports beneficial cardiovascular effects of glucagon-like peptide 1 (GLP-1), emerging studies suggest that glucose-dependent insulinotropic peptide (GIP) and/or signaling via the GIP receptor may have untoward cardiovascular effects. More...
30 Nov 2020
Image: An increase in Plasma P-tau217 may be considered as an early Alzheimer disease biomarker (Photo courtesy of Harvard Medical School).

Biomarker Detects Early Alzheimer’s Disease

In Alzheimer disease (AD), abnormal metabolism of amyloid-β (Aβ) and tau leads to accumulation of extracellular plaques formed by misfolded Aβ and intraneuronal neurofibrillary tangles containing phosphorylated tau (P-tau) protein. More...
24 Nov 2020
Image: Elevated fructosamine levels were associated with increased periprosthetic joint infection risk (Photo courtesy of Kristine Houck, MA).

Elevated Fructosamine Levels Associated with Increased PJI Risk

Periprosthetic joint infection (PJI) is the most serious complication that lowers the quality of patients’ life by elevating the patients’ burden of cost and affecting the outcome of total joint arthroplasty. More...
24 Nov 2020
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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