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Clinical Chemistry

Image: Low levels of bicarbonate in the blood were linked to a higher risk of progression to chronic kidney disease (Photo courtesy of Blood Tests London).

Pediatric CKD Progression Linked to Low Serum Bicarbonate

Metabolic acidosis is a serious electrolyte disorder characterized by an imbalance in the body's acid-base balance. Metabolic acidosis has three main root causes: increased acid production, loss of bicarbonate, and a reduced ability of the kidneys to excrete excess acids. More...
02 Jul 2020
Image: Presepsin concentrations (ng/mL) in two severity groups. Black line: sepsis patients; black dotted line: septic shock patients (Photo courtesy of University Hospital for Infectious Diseases in Zagreb).

Presepsin Values Evaluated as Sepsis Severity Markers

Sepsis is a life-threatening condition, with poor and highly variable clinical manifestations, difficult to identify and diagnose. Sepsis has remained a real diagnostic challenge to clinicians, causing millions of death worldwide each year. Early recognition of sepsis is crucial for better disease outcome. More...
23 Jun 2020
Image: Thyroid-stimulating hormone variations in pregnancy may prompt erroneous subclinical thyroid disease diagnosis (Photo courtesy of HealthEngine).

Pregnancy TSH Variations Prompt Erroneous Thyroid Disease Diagnosis

Thyroid-stimulating hormone is a pituitary hormone that stimulates the thyroid gland to produce thyroxine, and then triiodothyronine which stimulates the metabolism of almost every tissue in the body. More...
22 Jun 2020
Image: The single gene, Cystic Fibrosis Transmembrane Regulator (CFTR) gene is located on the long arm of chromosome 7, and its mutations cause CF (Photo courtesy of Daryl Isaac).

Biomarkers Evaluated for Lung Disease Severity in Cystic Fibrosis

Cystic fibrosis (CF) is one of the most common life-shortening monogenic disorders amongst European-derived populations currently affecting more than 85,000 patients worldwide. The diagnosis of CF is based on consensus clinical and laboratory criteria. More...
22 Jun 2020
Image: A Thermo Fisher Orbitrap ID-X mass spectrometer used to analyze blood plasma metabolites in ALS patients (Photo courtesy of North Carolina State University).

Metabolite Profiling Reveals Predictive Biomarkers for Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is characterized by stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size. It may begin with weakness in the arms or legs, or with difficulty speaking or swallowing. More...
11 Jun 2020
Image: The Varioskan LUX multimode microplate reader (Photo courtesy of Thermo Fisher).

Serum Free Thiols Predict Cardiovascular Events

Cardiovascular disease (CVD) is among the leading causes of morbidity and mortality globally, and during the past decade, the number of CVD-associated deaths has increased by 12.5%. Free thiols associate with favorable disease outcomes in many patient cohorts, and the current hypothesis is that oxidative stress might also play an important role in cardiovascular disease. More...
08 Jun 2020
Image: FlexStation 3 Microplate Reader measures absorbance, fluorescence intensity, fluorescence polarization, luminescence, and time-resolved fluorescence (Photo courtesy of Molecular Devices).

Urine Testing Method Developed for Ureterolithiasis

Ureterolithiasis (nephrolithiasis or kidney stones) is a disease affecting the urinary tract. Kidney stones occur due to buildup of certain salts and minerals that form crystals, which in turn stick together and enlarge to form a hard mass in the kidneys. The stones move into the urinary tract and can cause blood in the urine, considerable pain and blockages in the urinary system. More...
03 Jun 2020
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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