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BioResearch

Small Molecule Male Contraceptive Found to Be Safe and Reversible in Mouse Model

A prototype orally administered male contraceptive based on a small molecule that prevents sperm development was tested successfully in a mouse model. More...
30 Aug 2012

Strengthening Tumor Blood Vessels Could Improve Delivery of Anticancer Drugs

Since poor blood circulation to tumors may mean that anticancer drugs fail to reach their target in high enough concentration to be effective, some cancer researchers are suggesting a radical approach to normalize tumor blood supply. More...
30 Aug 2012
Image: Mouse stem cells with both normally functioning copies of the Mof gene (left) have intact "stem-ness", that is lost in cells lacking one or both functional copies (middle and right) (Photo courtesy of Prof. Yali Dou’s laboratory, University of Michigan).

Key Role Discovered for Enzyme in Preserving Essence of Stem Cells

A highly conserved yet unique acetyltransferase has now been shown to be essential in maintaining the self-renewal and pluripotent capacities of embryonic stem cells. More...
29 Aug 2012

Combined Chemotherapy and Immunotherapy Treatment Halts Growth of Metastatic Melanoma

A treatment for metastatic melanoma combines chemotherapy with the recently approved BRAF inhibitor vemurafenib, and immunotherapy with adoptive cell transfer therapy using lymphocytes genetically modified with a T-cell receptor recognizing chicken ovalbumin. More...
29 Aug 2012

Genotoxic Genes in Certain Gut Bacteria Linked to Chronic Bowel Inflammation and Colon Cancer

Certain strains of gut bacteria - Escherichia coli bearing the polyketide synthase  cluster of genotoxic genes – have been linked to chronic inflammatory bowel diseases such as Crohn's disease and ulcerative colitis and to the development of colorectal cancer. More...
29 Aug 2012

Gene Linked to the Unrestricted Production of Immature Blood Cells in Acute Myeloid Leukemia

Overexpression of the HLX gene characterizes cancer cells in patients with acute myeloid leukemia and correlates with increased severity of the disease and shortened survival time. More...
29 Aug 2012

More Evidence Suggests Passenger Gene Deletions Increase the Vulnerability of Cancer Cells to Chemotherapy

The theory that loss of tumor suppressor genes in cancerous cells is accompanied by the loss of copies of other genes critical to cell survival received strong backing from results obtained in experiments using a mouse brain cancer model. More...
28 Aug 2012
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.