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BioResearch

Image: As proof of the power of their new screening strategy, researchers at The Scripps Research Institute used the method to identify a compound that shows promise for treating obesity-linked diabetes. This image shows a structure identified as a target for obesity-diabetes (human Ces3), superimposed on a field of human fat cells with their lipids stained with a fluorescent dye (Photo courtesy of the Scripps Research Institute).

Combination Drug Screening Strategy Identifies Obesity-Diabetes Treatment Target

A drug discovery strategy that combined phenotypic screening with a target-identification approach was used to identify a novel drug target that, when treated, relieved symptoms of metabolic disease in mouse models.  More...
02 Jan 2014
Image: Colonies of Escherichia coli growing in a laboratory culture (Photo courtesy of the CDC - Centers for Disease Control and Prevention).

Deadly Drug-Resistant Strain of Escherichia coli Emerged as a Single Genetic Clone

Molecular microbiologists working with advanced genomic research tools have shown that an extremely virulent and drug-resistant strain of Escherichia coli appeared about 10 years ago following mutations in two genes.  More...
02 Jan 2014
Image: Phase contrast showing location of whole cells (Photo courtesy of Prof. C.L. Jaffe, Hebrew University, and of PLOS One).

Unique Kinase Found Important for Parasite Survival and Virulence

A unique protein kinase secreted by the human parasite Leishmania was found to be important for the parasite's growth and virulence, making it a potential new chemotherapeutic target against leishmaniasis.  More...
01 Jan 2014
Image: Scanning electron micrograph (SEM) showing numerous clumps of methicillin-resistant Staphylococcus aureus (MRSA) magnified 4,780x (Photo courtesy of the CDC - Centers for Disease Control and Prevention).

Antitoxin Vaccine Protects Laboratory Animals Against Staphylococcus Infection

A vaccine comprising a cocktail of superantigens and cytolysins protected rabbits challenged with virulent strains of Staphylococcus aureus while vaccines based on bacterial surface antigens failed to protect the animals or actually increased the severity of the infection.  More...
31 Dec 2013

Improved Molecular Backbone Enhances Function of RNA Interference Tools

Biotechnology researchers have reported significant progress in the development of synthetic RNAi tools by enhancing the efficiency of the molecule's 30-nucleotide backbone.   More...
31 Dec 2013
Image: Artist impression of a graphene sheet (Photo courtesy of the University of Manchester).

Graphene Sandwich Technology Reveals Clues into Inner Workings of Proteins

British scientists have discovered that the most fragile, microscopic compounds can be saved from the harmful effects of radiation when under the microscope if they are “sandwiched” between two sheets of graphene.   More...
30 Dec 2013

Research Data Declines Rapidly with Article age

A new study reveals that the vast majority of raw data from old studies is missing, making the reproducibility of results, a cornerstone of science, unavailable.  More...
30 Dec 2013
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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