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BioResearch

Image: Protein M, an unusual bacterial protein, attaches to virtually any antibody, possibly helping bacteria establish long-term infections. Compared to thousands of known structures, this protein appears to be unique (Photo courtesy of the Scripps Research Institute).

A Unique Mycoplasma Protein Generically Binds All Types of Antibodies and Blocks Antigen Binding

A team of molecular biologists has isolated a bacterial protein that binds to all types of antibodies and prevents them attaching to their specific antigens. More...
20 Feb 2014

Cardiac Tissue Generated from Human Embryonic Stem Cells Displays Aspects of Both Mature and Immature Heart Muscle

An in vitro model system based on cardiac tissue generated from human embryonic stem cells displayed some of the physiological responses known to occur in the natural adult human heart while other responses more closely mimicked the immature or newborn human heart.  More...
19 Feb 2014
Image: MIT engineers designed nanoparticles that can deliver short strands of RNA (green) into cells (nuclei are stained blue) (Photo courtesy of Gaurav Sahay, Yizhou Dong, and Omid Veiseh).

Nanoparticles Provide Optimal Gene Silencing, Potential for Liver Disease Treatment

Chemical engineers, inspired by tiny particles that carry cholesterol through the body, have designed nanoparticles that can deliver bits of genetic material that turn off disease-causing genes.   More...
19 Feb 2014
Image: As seen through a microscope, the leg bone of a normal mouse (left) makes considerably less new bone than a mouse that produces high levels of a signaling protein, WNT7B, that stimulates new bone growth (shown in pink on the right). The protein could become a target for new drugs to treat osteoporosis and other conditions related to bone loss (Photo courtesy of Washington University School of Medicine).

Generation of New Bone Depends on WNT Stimulation of the mTORC1 Pathway

The WNT signaling protein WNT7B potently enhances formation of new bone through activation of mTORC1 in a mouse osteoporosis model.  More...
18 Feb 2014
Image: A diorama at the Neanderthal museum in Croatia. A substantial fraction of the Neanderthal genome persists in modern human populations. A new approach applied to analyzing whole-genome sequencing data from 665 people from Europe and East Asia shows that more than 20% of the Neanderthal genome survives in the DNA of this contemporary group, whose genetic information is part of the 1000 Genomes Project (Photo courtesy of Max Planck Institute).

Sizeable Neanderthal Genome Still Exists in Modern Humans

A new strategy for analyzing whole-genome sequencing data from 665 people from Europe and East Asia revealed that more than 20% of the Neanderthal genome survives in the DNA of this contemporary group.  More...
18 Feb 2014
Image: The external face of the Flavivirus NS1 protein (sugars in grey balls) is exposed on infected cell surfaces where it can interact with the immune system. This face is also exposed in secreted NS1 particles present in patient sera. The background image shows artificial membranes coated with the NS1 protein (Photo courtesy of the University of Michigan).

X-Ray Crystallography Reveals the Two Faces of Flavivirus Nonstructural Protein

High-resolution X-ray crystallography and electron microscopy have revealed that the Flavivirus NS1 has two distinct faces, one that interacts with the interior of the infected host cell and the other that is exposed to antiviral elements in the host's immune system.  More...
17 Feb 2014

DNA-Constructed Nanoparticles Safely Target Tumors

A team of Canadian researchers has discovered a way to assemble “building blocks” of gold nanoparticles as the vehicle to deliver cancer medications or cancer-identifying markers directly into cancerous tumors.  More...
17 Feb 2014
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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