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BioResearch

Image: Graphic explaining the consequences of the loss of function of RARRES3 for breast cancer lung metastasis (Photo courtesy of the Institute for Research in Biomedicine).

Loss of Tumor Suppressor Gene Promotes Breast Cancer Metastasis into the Lungs

Cancer researchers have found that loss of a specific tumor suppressor gene promotes the metastasis of breast cancer cells into the lungs.  More...
08 Jun 2014
Image: A general synthetic route was developed to encapsulate small molecules in monodisperse zeolitic imid-azolate framework-8 (ZIF-8) nanospheres for drug delivery. Electron microscopy, powder X-ray diffraction, and elemental analysis show that the small-molecule-encapsulated ZIF-8 nanospheres are uniform 70-nm particles with single-crystalline structure. Several small molecules, including fluorescein and the anticancer drug camptothecin, were encapsulated inside of the ZIF-8 framework. Evaluation of fluorescein-encapsulated ZIF-8 nanospheres in the MCF-7 breast cancer cell line demonstrated cell internalization and minimal cytotoxicity. The 70 nm particle size facilitates cellular uptake, and the pH-responsive dissociation of the ZIF-8 framework likely results in endosomal release of the small-molecule cargo, thereby rendering the ZIF-8 scaffold an ideal drug delivery vehicle. To confirm this, the researchers demonstrated that camptothecin encapsulated ZIF-8 particles show enhanced cell death, indicative of internalization and intracellular release of the drug. To demonstrate the versatility of this ZIF-8 system, iron oxide nanoparticles were also encapsulated into the ZIF-8 nanospheres, thereby endowing magnetic features to these nanospheres Photo courtesy of the  American Chemical Society (ACS) journal ACS Nano).

Smart Drug-Delivery Cage Designed to Fight Cancer

Chemists have developed a nano-scale cage of chemical bonds that entraps small molecule drugs and then infiltrates cancer cells, showing potential to act as a “smart” drug-delivery processes to fight cancer and other disorders.  More...
04 Jun 2014

Complete Response Rates Seen in Refractory Melanoma Patients

New research examines complete response and induced immune response in melanoma patients that may generate a “bystander effect.”  More...
04 Jun 2014
Image: The SPINlab platform (Photo courtesy of GE Healthcare).

Hyperpolarized Carbon Technology Enables Researchers to See Cell Activity in Real Time

A newly devised hyperpolarizing system works by controlling the power of hyperpolarized carbon 13C (C-13), so that researchers can now see metabolic biochemical changes in cells as they occur.  More...
03 Jun 2014

Enzyme Identified That Promotes Aggressive Forms of Pancreatic Cancer

Cancer researchers have identified an enzyme that seems to cause pancreatic tumors to act in a much more aggressive – and therefore lethal – fashion.   More...
03 Jun 2014

Leelamine Blocks Melanoma Growth by Disrupting Cellular Cholesterol Transport

An experimental chemotherapeutic drug interferes with intracellular cholesterol transport, which kills melanoma cells by disrupting several molecular pathways simultaneously.  More...
03 Jun 2014
Image: The CAMSIZER P4 particle size and shape analyzer (Photo courtesy of Retsch Technology).

Enhanced and Upgraded Particle Size and Shape Analyzer Now Available

An upgraded and enhanced version of a well-proven system for the determination of particle size and shape has recently become available.  More...
02 Jun 2014
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.