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BioResearch

Roche Acquires Signature Diagnostics to Advance Translational Research

Roche will advance translational research for next generation sequencing diagnostics by leveraging the unique expertise of Signature Diagnostics in biobanks and development of novel NGS diagnostic assays.  More...
15 Feb 2015
Image: Clusters of ovarian clear cell carcinoma due to mutations in the genes ARID1A and PIK3CA (Photo courtesy of Dr. Ron Chandler, University of North Carolina).

Simultaneous Mutations Underlie Ovarian Cancer in Mouse Model

Studies carried out on a mouse model of human ovarian clear-cell carcinoma showed that simultaneous mutations in two genes were required to stimulate tumor development.  More...
11 Feb 2015
Image: Space-filling molecular model of epigallocatechin gallate (EGCG)(Photo courtesy of Wikimedia Commons).

Alternative Cancer Treatments May Be Based on Green Tea Components

A recent paper suggested that the green tea component epigallocatechin-3-gallate could be developed into an alternative treatment for oral cancer that would not have the severe side effects of current chemotherapeutic agents.   More...
10 Feb 2015
Image:  Graphical summary of a new study showing that athletic performance (and therefore sport event outcome) also depends on the circadian rhythms of individual athletes (Photo courtesy of University of Birmingham and Cell Press).

Outcome of Sports Events May Depend on Circadian Rhythms

According to a new study, the outcome of sporting events may depend on how well the timing of the match aligns with the internal biological clocks of the athletes, and so could change performance by the hour depending on what time it is for their inner clock.   More...
10 Feb 2015
Image: Micrograph showing a rat cell re-programmed to express HNF-6 (red) and insulin (green). The nucleus is stained blue (Photo courtesy of Cornell University).

Genetically Engineered Lactobacilli Cure Diabetes in Rat Model

A novel concept for treating diabetes was demonstrated by feeding diabetic rats a diet containing human lactobacilli that had been genetically engineered to secrete the protein glucagon-like peptide-1 GLP-1, which induced significant long-term increases in insulin levels.   More...
09 Feb 2015

Defective Cell Extrusion May Lead to Formation of Tumors in Pancreas, Lungs, or Colon

The disruption of normal S1P2 receptor activity in epithelial cells prevents the pro-apoptotic extrusion of cells from overcrowded tissue and leads to the formation of cancerous growths in the pancreas, lung, and colon.  More...
09 Feb 2015
Image: Researchers reprogrammed human skin cells to create induced pluripotent stem cells, which were then differentiated in a stepwise fashion to create insulin-producing cells. When these cells were transplanted into diabetic mice, the cells secreted insulin and reduced the blood sugar levels of the mice to normal or near-normal levels. The micrograph shows the insulin-producing cells (right) and precursor cells (left) (Photo courtesy of the University of Iowa).

Stem Cell Therapy Cures Diabetes in Mouse Model

Diabetes researchers modified human skin cells to produce insulin and showed that after being injected into diabetic immunodeficient mice, the cells developed into an insulin-producing organoid capable of modulating the animals' glucose metabolism.  More...
08 Feb 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.