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BioResearch

Image: Neuromuscular tissue engineering: hiNSCs (red) grown in co-culture with skeletal muscle (green), with cell nuclei visualized by blue DAPI staining (Photo courtesy of Dr. Dana M. Cairns, Tufts University).

New Approach Yields Stable Neural Stem Cell Lines for Neuroscience Research

A team of neurosciences researchers developed a faster and more stable technique for establishing stable human induced neural stem cell (hiNSC) lines through the direct reprogramming of neonatal fibroblasts and adult adipose-derived stem cells. More...
27 Sep 2016
Image: Scientists developed nanoparticles for targeted delivery of chemotherapy. When combined with other cancer treatments, it eradicated tumors in rodents in a recent study (Photo courtesy of Dr. Cecil Fox via Wikimedia Commons).

Light-Activated Nanoparticles Kill Primary Tumors and Distant Metastases

A novel type of nanoparticle carries two anticancer drugs to attack colorectal cancer while simultaneously recruiting and activating T-cells to fight the tumors. More...
27 Sep 2016
Image: A digitally colorized scanning electron micrograph (SEM) showing a blue-colored human neutrophil interacting with two pink-colored, rod-shaped Klebsiella pneumoniae bacteria (Photo courtesy of the NIAID).

Siderophores Induce Pneumonia-Promoting Changes in Lung Tissue

Siderophores, which are small, high-affinity iron chelating compounds secreted by some types of microorganisms, were found to act directly on the host to induce inflammatory cytokines and to aid in bacterial dissemination. More...
26 Sep 2016
Image: Lung cancer cells (Photo courtesy of SPL).

Novel Class of Nanoparticle Drug Transporters Selectively Target Lung Cancer Cells

A novel class of nanoparticles is able to deliver siRNA-based drugs selectively to lung cancer cells without harming normal cells. More...
26 Sep 2016
Image: A photomicrograph of bone marrow aspirate showing acute myeloid leukemia (AML) (Photo courtesy of Wikimedia Commons).

Inhibiting Enzyme Activity Overcomes Cell Differentiation Blockade

Inhibition of the enzyme dihydroorotate dehydrogenase (DHODH) was found to stimulate differentiation of acute myeloid leukemia (AML) cells, which reduced the cancer cell burden and promoted survival in human and mouse models. More...
26 Sep 2016
Image: Comparison of the structures of insulin in Conus geographus (red/white) and in humans (blue/white and green). The green B-chain terminal segment is absent in the C. geographus insulin (Photo courtesy of Dr. Mike Lawrence).

Snail Insulin Serves as Drug Development Model

A form of insulin isolated from a type of carnivorous marine snail lacks the segment of the B region that causes the protein to aggregate, which decreases the amount of time required by the hormone to influence glucose levels by a factor of three. More...
22 Sep 2016
Image: Researchers have discovered that the drug pioglitazone, used to treat diabetes, shows some ability to halt the overexpression of the protein NAF-1, which has been associated with the proliferation of breast cancer (Photo courtesy of Fang Bai, Rice University).

Stabilizing Iron-Sulfur Transport Clusters Reduces Size and Aggressiveness of Tumors

An international team of cancer researchers has identified a protein that, when overexpressed, enabled breast tumors to better withstand oxidative stress thereby becoming much larger and more aggressive. More...
21 Sep 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.