BioResearch
Rapid Immunopurification Technique Enables Accurate Determination of Mitochondrial Metabolites
A rapid immunopurification technique was used to isolate mitochondria with metabolite contents that were relatively undamaged by enzyme activity and free from components of other cellular organelles. More...14 Sep 2016
Modified Version of CRISPR/Cas9 Identifies Parasite Infectivity Genes
A modified version of the CRISPR/Cas9 gene editing system was used to map the genome of the apicomplexan parasite Toxoplasma gondii, which, in addition to revealing which genes were necessary for this pathogen's survival, gave insights into genes necessary for infection by the malaria parasite Plasmodium falciparum. More...13 Sep 2016
Human Liver Organoids Thrive When Transplanted into Mouse Liver Failure Model
Liver disease researchers have demonstrated in a mouse model that it may be feasible to treat some types of liver failure with transplanted multicellular liver organoid units composed of a heterogeneous cellular population that includes adult stem and progenitor cells. More...13 Sep 2016
Novel Human Monoclonal Antibody Shows Promise for Treating Alzheimer's Disease
A human monoclonal antibody that targets aggregated forms of amyloid-beta (Abeta) protein was shown in a phase Ib clinical study to reduce amyloid plaques in patients with early Alzheimer's disease and to slow or prevent cognitive decline in these individuals. More...12 Sep 2016
High-Resolution Analysis of Leishmanial Ribosome Provides Clues for Drug Design
Derived from a 2.8-Å cryo-EM map, researchers have achieved an atomic resolution structure of the Leishmania donovani large ribosomal subunit (rLSU). Comparison with other eukaryotes and with bacteria provides an important framework for better understanding ribosome biogenesis and a solid structural basis for developing highly selective therapeutics against Leishmania and closely related parasites. More...08 Sep 2016
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CD1a on Langerhans Cells Controls Some Types of Skin Inflammation
Neuregulin-1 Identified As Potential Alzheimer's Disease Treatment
Malignant Melanoma Releases MicroRNAs to Condition the Dermis Prior to Metastasis
Novel Monkey Model to Enable Study of Dormant Herpes Infections
Single Molecule Imaging Reveals How Telomerase Finds and Binds to the Telomere
Release of ApoE4 Fragments and Increased Tau Protein Contribute to Risk of Alzheimer's Disease
Researchers Identify Cell Surface Protein Required for Norovirus Infection
Kinase Domain Mutation Causes Protein Malfunction and Tumor Development
Unrelated Single-Stranded DNA Increases Efficiency of CRISPR-Cas 9 Gene Editing
Gene Editing Corrects Hemoglobin Defects in Beta-Thalassemia and Sickle Cell Disease
Long Non-Coding RNAs Linked to Development and Progression of Prostate Cancer
NADPH Oxidase Inhibitor Treatment Protects Mice from Being Killed by Pneumonia
Magnetically Guided Bacteria Transport Drug-Loaded Liposomes to Hypoxic Tumors
Phase II Trial Confirms Potential of Venetoclax for Acute Myeloid Leukemia
Zika Virus Proteins Linked to Fetal Microcephaly through Activation of Autophagy Pathway
Lung Cell Protein Triggers a Dangerous Immune Response
Antibiotics-Induced Changes to Gut Bacteria Influence Expression of Drug Side Effects
Genetic Engineers Use CRISPR/Cas9 to Transform Fibroblasts into Neurons
Hydroxycitrate Potentially More Effective Than Citrate for Kidney Stones
BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.