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BioResearch

Image: The micrograph shows cross-sections of healthy nerve axons with a thick layer of myelin, the insulation that speeds the propagation of electrical signals through the nervous system\'s wiring. When properly folded, prion proteins play a vital role in maintaining this insulating layer of myelin (Photo courtesy of Amit Mogha, Washington University School of Medicine).

Normal Prion Protein Maintains Myelin Integrity in Nervous System

Researchers studying chronic diseases of the brain have determined the function and mode of operation of the cellular prion protein PrPC, which in its cytotoxic form underlies prion diseases such as spongiform encephalopathy (mad cow disease) and its human counterpart, variant Creutzfeldt-Jakob disease. More...
17 Aug 2016
Image: Trypanosoma sp. parasites in blood smear from a patient with African trypanosomiasis (Photo courtesy of the CDC).

Experimental Drug May Be Universal Cure for Kinetoplastid-Based Diseases

An experimental drug that targets the kinetoplast proteasome found in several types of protozoan parasites shows potential for development into a universal treatment for these pathogenic microorganisms. More...
17 Aug 2016
Image: A molecular model of lectin-type oxidized LDL receptor 1 (Lox-1) (Photo courtesy of Wikimedia Commons).

LDL Receptor Expression Differentiates Myeloid-Derived Cells from Neutrophils

Cancer researchers have identified a surface protein marker on myeloid-derived suppressor cells (MDSCs) that differentiates them from normal neutrophils and may be a potential therapeutic target. More...
17 Aug 2016
Image: The chemical structure of the probe, and the possible probe-dsRNA triplex structure (Photo courtesy of Tohoku University).

Japanese Scientists Describe Powerful Fluorescent Probe for Studying RNA

A team of Japanese biochemists has described the development of a powerful new fluorescent probe for studying the structure and function of double stranded RNA (dsRNA). More...
16 Aug 2016
Image: The experiments were carried out with nanoparticles of different sizes and structures. The first two of the series consisted of solid gold and the last consisted of a core of glass with a surface of gold. The beads were illuminated with near infrared light with wavelengths of 807 nanometers and 1064 nanometers. The most effective nanoparticle was the gold-plated glass bead (Photo courtesy of Kamilla Nørregaard, University of Copenhagen).

Laser-Heated Plasmonic Nanoparticles Safely Cause Localized Tumor Destruction

Cancer therapy based on plasmonic nanoparticles that homed to tumors, warmed on exposure to laser irradiation, and then selectively killed the cancer cells was optimized and shown to be effective in a mouse xenograft model. More...
16 Aug 2016
Image: Blocking JAM-C on lymphoma cells inhibits their migration through vessel walls (Photo courtesy of the Université de Genève).

Monoclonal Antibody Treatment Blocks Lymphoma Progression in Mouse Model

Immunotherapy based on monoclonal antibodies that specifically bind to the surface protein junctional adhesion molecule (JAM)-C, which is expressed by a variety of different cell types, including human B lymphocytes and some B-cell lymphoma subtypes, blocked progression of lymphoma in a mouse xenograft model of mantle cell lymphoma. More...
16 Aug 2016
Image: An enhanced image of the Zika virus based on cryo-electron microscope data (Photo courtesy of Dr. Daved Fremont, Washington University School of Medicine).

Anti-Zika Virus Monoclonal Antibodies to Aid in Vaccine Development

Highly specific monoclonal antibodies have been produced that may play a crucial role in the development of a vaccine to treat Zika virus (ZIKV) infection or as the basis for rapid diagnostic tests to detect it. More...
11 Aug 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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