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BioResearch

Image: A model of the crystal structure of adenosine deaminase, one of the protein targets of DMF. The amino acid labeled by DMF is shown in pink, and neighboring residues associated with a human immunodeficiency are shown in yellow (Photo courtesy of The Scripps Research Institute).

Binding of Cysteine Residues Reduces Severity of Multiple Sclerosis

A recent paper explained the mode of action of dimethyl fumarate (DMF), the most effective drug currently in use for the treatment of multiple sclerosis (MS). More...
04 Oct 2016
Image: Researchers have identified a molecule that controls immune suppression, which could enhance molecular abilities to fight disease (Photo courtesy of Pixabay).

Macrophage Role in Infection Determined by PI-3 Kinase-Gamma Signaling

Cancer researchers have identified a molecule responsible for the signal that converts macrophages from an inflammatory, immunostimulatory mode in acute infections to an anti-inflammatory, immunosuppressive mode that supports tumor development and growth. More...
29 Sep 2016
Image: Supportive Schwann cells (green) surround the conductive axon (purple) of a neuron in the peripheral nervous system in this artificially colored image. Schwann cells not only make the insulating myelin (black), but also are active players in axon repair after damage (Photo courtesy of Dr. John Svaren, University of Wisconsin).

Damaged Nerve Regeneration Depends on Epigenetic Regulation of Cell Genes

A team of neuroscientists has identified a key epigenetic step that enables Schwann cells to initiate regeneration of damaged axons in the peripheral nervous system (PNS). More...
29 Sep 2016
Image: Three-dimensional (3D) bioengineered lung-like tissue (left) resembles adult human lung (right) (Photo courtesy of UCLA).

3D Bioengineering Generates Lung Tissue for Personalized Disease Modeling

Lung disease researchers have developed a novel three-dimensional (3D) culture method for transforming stem cells into lung-like tissue that can be used to study diseases including idiopathic pulmonary fibrosis (IPF), which has traditionally been difficult to study using conventional methods. More...
28 Sep 2016
Image: The structure of the VCP protein (Photo courtesy of Wikimedia Commons).

Protein Linked to Destruction of Mitochondria in Huntington's Disease

Researchers studying the molecular mechanisms involved in Huntington's disease (HD) have identified a protein that binds to mutant huntingtin protein in the mitochondria of neurons, which results in destruction of the mitochondria and death of the nerve cells. More...
28 Sep 2016
Image: The structure of the SET protein (Photo courtesy of Wikimedia Commons).

Reactivation of p53 Shrinks Tumors in Mouse Model

Blocking a protein that inhibits lysine acetylation reversed the inactivation of the p53 protein and resulted in shrinkage of tumors in a mouse xenograft model. More...
27 Sep 2016
Image: Neuromuscular tissue engineering: hiNSCs (red) grown in co-culture with skeletal muscle (green), with cell nuclei visualized by blue DAPI staining (Photo courtesy of Dr. Dana M. Cairns, Tufts University).

New Approach Yields Stable Neural Stem Cell Lines for Neuroscience Research

A team of neurosciences researchers developed a faster and more stable technique for establishing stable human induced neural stem cell (hiNSC) lines through the direct reprogramming of neonatal fibroblasts and adult adipose-derived stem cells. More...
27 Sep 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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