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BioResearch

Image: The molecular model of tyrosine kinase c-Src (Src) (Photo courtesy of Wikimedia Commons).

Controlling the Transient Activation of Protein Kinases in Living Cells

The study of the effects of protein kinase enzymes in living cells has been enhanced by the development of a technique to control when and for how long a specific kinase is active. More...
27 Dec 2016
Image: Combining CRISPR with the fine resolution of single-cell RNA sequencing gives researchers new means of controlling cell activities (Photo courtesy of the Weizmann Institute of Science).

Combined Gene Editing and RNA Sequencing Enhances Understanding of Gene Expression

A team of Israeli molecular geneticists has combined two powerful genomics tools to study single cell gene expression. More...
27 Dec 2016
Image: Members of the TET protein family protect against cancer. Left: Normal liver in mice with fully functional TET proteins. Right: Without TET2 and TET3, mice develop a lethal disease resembling lymphoma within weeks of birth, their livers overloaded with iNKT cells (Photo courtesy of Dr. Angeliki Tsagaratou, La Jolla Institute for Allergy and Immunology).

Development of Leukemia and Lymphoma Traced to Loss of T-cell Differentiation Controls

Loss of TET protein tumor suppressor activity disrupts white blood cell development, which can lead to leukemia, lymphoma, and other cancers. More...
22 Dec 2016
Image: A molecular model of the UCHL3 (Ubiquitin carboxyl-terminal hydrolase isozyme L3) enzyme, a critical regulator of double-strand DNA repair (Photo courtesy of Wikimedia Commons).

Enzyme Identified Promotes Cancer Development by Mishandling Repair of DNA Breaks

Cancer researchers have identified an enzyme linked to defective repair of damaged DNA, which is a mechanism that prevents cell death and mediates transformation into a cancerous state. More...
22 Dec 2016
Image: A micrograph showing invasive adenocarcinoma (the most common type of colorectal cancer). The cancerous cells are seen in the center and at the bottom right of the image (blue). Near normal colon-lining cells are seen at the top right of the image (Photo courtesy of Wikimedia Commons).

Mechanism Explains How Colon Cancer Suppressor Protein Works

The intracellular protein NLRC3 (NLR family CARD domain containing 3) blocks growth of colon cancer by suppressing activation of mTOR (Mechanistic target of rapamycin) signaling pathways. More...
22 Dec 2016
Image: A molecular model of the argininosuccinate synthetase 1 (ASS1) protein (Photo courtesy of Wikimedia Commons).

Novel Approach to Bladder Cancer Chemotherapy Based on Arginine Depletion

Studies conducted on arginine-dependent bladder cancer cell cultures and mouse xenografts revealed that this cancer is highly susceptible to treatment with a drug compound comprising the enzyme arginine deiminase (ADI) conjugated to polyethylene glycol (PEG). More...
21 Dec 2016
Image: A molecule model of a CRISPR (clustered regularly interspaced short palindromic repeats) and a DNA fragment from E. coli (Photo courtesy of Wikimedia Commons).

Anti-CRISPR Proteins Increase Safety and Accuracy of Gene Editing

A set of naturally occurring proteins has been identified that specifically inhibits the action of the CRISP/Cas9 molecular genome-editing complex and thereby greatly increases its accuracy as a tool for manipulating gene expression. More...
21 Dec 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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